• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Computational understanding of the mechanism of motor ataxia

Research Project

Project/Area Number 23700360
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bioinformatics/Life informatics
Research InstitutionNTT Communication Science Laboratories (2013)
Advanced Telecommunications Research Institute International (2011-2012)

Principal Investigator

IZAWA Jun  日本電信電話株式会社NTTコミュニケーション科学基礎研究所, 人間情報研究部, リサーチスペシャリスト (20582349)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords運動学習 / 運動制御 / 小脳 / 発達障害 / 計算理論 / 内部モデル / 運動のばらつき / 自閉症 / 脳疾患
Research Abstract

The aim of this research is to understand the computational mechanism of how the damage of the brain generates motor deficits using the recently established computational framework of motor learning which is based on stochastic optimization theory. We proposed a motor adaptation system as a combination of optimal state estimator and optimal control mechanism and discussed a consistency between the propose model and previously discussed behavioral data. To confirm this idea, a new paradigm of a behavioral experiment was developed. We confirmed that the representation of internal model in the brain is not deterministic rather than stochastic. Then, the learning experiment with the cerebellar ataxia showed that updating sensory estimation was impaired whereas updating motor commands were preserved. This suggests that the cerebellum is responsible for forward model.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (17 results)

  • [Journal Article] The influence of uncertain force environment on reshaping trial-to-trial motor variablity2014

    • Author(s)
      Izawa J, Yoshioka T, Osu R
    • Journal Title

      NeuroReport

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebellar contributions to reach adaptation and learning sensory consequences of action2012

    • Author(s)
      Izawa J, Criscimagna-Hemminger SE, and Shadmehr R
    • Journal Title

      The Journal of Neuroscience

      Volume: 32(12) Pages: 4230-4239

    • Related Report
      2013 Final Research Report
  • [Journal Article] Motor learning relies on integrated sensory inputs in ADHD, but over-selectively on proprioception in Autism spectrum conditions2012

    • Author(s)
      Izawa J, Pekny SE, Marko MK, Haswell CC, Shadmehr R, and Mostofsky SH
    • Journal Title

      Autism Research

      Volume: 5 Pages: 124-136

    • Related Report
      2013 Final Research Report
  • [Journal Article] Analysis of extrinsic and intrinsic factors affecting event related desynchronization production.2012

    • Author(s)
      Yohei Takata
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc.

      Volume: 2012 Pages: 4619-22

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Motor learning relies on integrated sensory inputs in ADHD, but Over-Selectively on Proprioception in Autism Spectrum Conditions2012

    • Author(s)
      Jun IZAWA
    • Journal Title

      Autism Research

      Volume: 5 Pages: 124-136

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cerebellar Contributions to Reach Adaptation and Learning Sensory Consequences of Action2012

    • Author(s)
      Jun Izawa, Sarah E. Criscimagna-Hemminger, and Reza Shadmehr
    • Journal Title

      Journal of Neuroscience

      Volume: 32(12) Issue: 12 Pages: 4230-4239

    • DOI

      10.1523/jneurosci.6353-11.2012

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stimulation of the human motor cortex alters generalization patterns of motor learning2011

    • Author(s)
      Orban de Xivry J, Marko MK, Pekny SE, Pastor D, Izawa J, Celnik P, and Shadmehr R
    • Journal Title

      The Journal of Neuroscience

      Volume: 31(19) Pages: 7102-7110

    • Related Report
      2013 Final Research Report
  • [Journal Article] The influence of uncertain force environment on reshaping trial-to-trial motor

    • Author(s)
      Izawa J, Yoshioka T, Osu R
    • Journal Title

      NeruroReport

      Volume: (accepted,印刷中)

    • Related Report
      2013 Final Research Report
  • [Presentation] Mechanisms for Generating Intermittency during manual tracking task, pp.559-5562013

    • Author(s)
      Asano T, Izawa J, Sakaguchi Y
    • Organizer
      Advances in Cognitive Neurodynamics (III), Proceedings of the Third International Conference on Cognitive Neurodynamics . 2011, ed.Yamaguchi,Yoko, Springer
    • Related Report
      2013 Final Research Report
  • [Presentation] 6th International IEEE/EMBS Conference on Neural Engineering (IEEE NER)2013

    • Author(s)
      Ozawa T, Aihara T, Fujiwara Y, Otaka Y, Nambu I, Osu R, Izawa J, Wada Y
    • Organizer
      Detecting event-related motor activity using functional near-infrared spectroscopy, pp1529-1532
    • Related Report
      2013 Final Research Report
  • [Presentation] Clamping errors selectively accentuated a cost-driven update of motor memory2013

    • Author(s)
      Izawa J, Yoshioka T, Osu R, Gomi H
    • Organizer
      Society for Neuroscience Meeting (SfN), 78.27/UU21
    • Related Report
      2013 Final Research Report
  • [Presentation] Detecting event-related motor activity using functional near-infrared spectroscopy2013

    • Author(s)
      Ozawa T, Aihara T, Fujiwara Y, Otaka Y, Nambu I, Osu R, Izawa J, Wada Y
    • Organizer
      6th International IEEE/EMBS Conference on Neural Engineering
    • Place of Presentation
      San Diego
    • Related Report
      2013 Annual Research Report
  • [Presentation] Clamping errors selectively accentuated a cost-driven update of motor memory2013

    • Author(s)
      Izawa J, Yoshioka T, Osu R, Gomi H
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      San Diego
    • Related Report
      2013 Annual Research Report
  • [Presentation] Brain structure constraints a cost for optimizaiton in muscle force distribution problem2013

    • Author(s)
      Kita K, Izawa J, Hosoda C, Honda M, Hanakawa T, Osu
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      San Diego
    • Related Report
      2013 Annual Research Report
  • [Presentation] Dissociating the roles of sensory prediction error and reward prediction error on the formation of motor memory during visuomotor adaptation2013

    • Author(s)
      Oh Y, Izawa J, Schweighofer N
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      San Diego
    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of regions and neural patterns relating limb selection using decoding of event-related and ongoing activity2013

    • Author(s)
      Amemiya K, Kurashige H, Yokoyama H, Izawa J, Osu R
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      San Diego
    • Related Report
      2013 Annual Research Report
  • [Presentation] Analysis of key factors on ERD production for BCI neuro-robotic rehabilitation, pp.240-2452012

    • Author(s)
      Takata Y, Saeki M, Izawa J, Takeda K, Otaka Y, Ito K, Kondo T
    • Organizer
      Proceedings of the IEEE RAS and EMBC International Conference on Biomedical Robotics and Biomechatronics(IEEE RAS EMBS)
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of extrinsic and intrinsic factors affecting event related desynchronization production, pp.4619-46222012

    • Author(s)
      Takata Y, Kondo T, Saeki M , Izawa J, Takeda K, Otaka Y, Ito K
    • Organizer
      2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC)
    • Related Report
      2013 Final Research Report
  • [Presentation] Internal model uncertainty reshapes trial-to-trial variability of motor commands2012

    • Author(s)
      Izawa J, Yoshioka T, and Osu R
    • Organizer
      Society for Neuroscience Annual Meeting (SfN) 88.15
    • Place of Presentation
      New Orleans, LA
    • Related Report
      2013 Final Research Report
  • [Presentation] 最適制御と運動学習2012

    • Author(s)
      井澤淳
    • Organizer
      日本生理学会大会(招待講演)
    • Place of Presentation
      信州大学(長野)
    • Related Report
      2011 Research-status Report
  • [Presentation] A role of cerebellum in maximizing rewards during visuomotor adaptation task"2011

    • Author(s)
      Izawa J, Criscimagna-Hemminger SE, and Shadmehr R
    • Organizer
      Society for Neuroscience Annual Meeting(SfN) , 836.3
    • Place of Presentation
      San Diego, CA
    • Related Report
      2013 Final Research Report
  • [Presentation] 運動学習と最適制御2011

    • Author(s)
      井澤淳
    • Organizer
      第5回Motor Control研究会
    • Place of Presentation
      自然科学研究機構(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 運動記憶の特性を表現する状態空間モデル

    • Author(s)
      井澤 淳
    • Organizer
      生理学研究所研究会 第6回Motor Control研究会
    • Place of Presentation
      自然科学研究機構 岡崎コンファレンスセンター(愛知県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 計算論的神経解剖学からアプローチするBMIリハビリテーション

    • Author(s)
      井澤 淳
    • Organizer
      電子情報通信学会MEとバイオサイバネティックス研究会
    • Place of Presentation
      豊橋技術科学大学(愛知県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Internal model uncertainty reshapes trial-to-trial variability of motor commands

    • Author(s)
      Jun IZAWA
    • Organizer
      Society for Neuroscience 42nd Annual Meeting(Neuroscience2012)
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi