Phosphatidylethanolamine as an organizing molecule for neurite extension
| Project/Area Number |
23700365
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Research Collaborator |
KANAHO Yasunori 筑波大学, 医学医療系, 教授 (00214437)
SUZUKI Atsushi 筑波大学, 大学院人間総合科学研究科, 博士課程学生
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 発生 / 発達 / 再生神経科学 / 神経細胞 / 細胞骨格 / ホスファチジルエタノールアミン |
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| Research Abstract |
We have examined whether and how phosphatidylethanolamine, a phospholipid consisting of the plasma membrane, is involved in neuronal morphogenesis. Our results indicated that the intramembranous movement (flip-flop movement) of phosphatidylethanolamine, which is induced by a type IV ATPase, controls neurite morphogenesis by organizing actin cytoskeleton in growth cones through the regulation of small G protein Cdc42.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis2012
Author(s)
Hasegawa, H., Noguchi, J., Yamashita, M., Okada, R., Sugimoto, R., Furuya, M., Unoki, T., Funakoshi, Y., Baba, T., and Kanaho, Y.
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Journal Title
Biol. Reprod
Volume: 86
Issue: 5
Pages: 1-12
DOI
Related Report
Peer Reviewed
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