Research Project
Grant-in-Aid for Young Scientists (B)
In this study, we used contextual fear conditioning, large-scale imaging with immediate early genes and whole-cell recordings to demonstrate the neuronal circuits underlying fear extinction and reinstatement and found the results described below.(1) The neuronal activity in the infralimbic cortex is decreased during fear reinstatement.(2) Neural plasticity in the infralimbic cortex is involved in fear reinstatement.(3) Excitatory synaptic currents onto infralimbic cortical neurons are reduced with fear reinstatement.(4) A specific subset of basolateral amygdala neurons is active during fear memory expression.(5) The basolateral amygdala neurons that are active during fear memory expression have different projection from the other neurons.Further analysis of our identified neuronal circuits will contribute to understanding the cellular mechanisms underlying fear extinction and reinstatement.
All 2013 2012 2011 Other
All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (100 results)
Brain Research
Volume: 1493 Pages: 19-26
10.1016/j.brainres.2012.11.030
Neurosci. Lett
Volume: 529 Issue: 1 Pages: 106-106
10.1016/j.neulet.2012.09.015
Eur. J. Neurosci
Volume: 36 Issue: 10 Pages: 3451-3457
10.1111/j.1460-9568.2012.08269.x
RSC Adv.
Volume: 2 Issue: 19 Pages: 7456-7461
10.1039/c2ra21123h
Neuroscience
Volume: 220 Pages: 19-25
10.1016/j.neuroscience.2012.06.043
Neuroreport
Volume: 23 Issue: 7 Pages: 457-461
10.1097/wnr.0b013e32835375b6
Neuroimage
Volume: 60 Issue: 1 Pages: 153-161
10.1016/j.neuroimage.2011.12.022
The International Journal of Neuropsychopharmcology
Volume: (In press) Issue: 04 Pages: 523-530
10.1017/s1461145711000708
J. Cell Sci.
Volume: 124 Issue: 17 Pages: 3006-3016
10.1242/jcs.085902
