| Project/Area Number |
23700369
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
HOJO Yasushi 東京大学, 総合文化研究科, 特任研究員 (20536875)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 海馬 / 記憶学習 / 急性ストレス / シナプス / スパイン / ストレスホルモン / コルチコステロン / リン酸化カスケード / ストレスステロイド |
|---|
| Research Abstract |
(1) We revealed that the molecular mechanism of spinogenesis induced by acute stress is“CORT→GR→Erk MAPK, PKA, PKC, PI3K→actin polymerization or rearrangement →spinogenesis and enlargement of spine head diameter”, which is completely different fromchronic stress effect with gene transcription.(2) We determined the concentration of hippocampus-synthesized CORT as 7 nM by using adrenalectomized rats and liquid chromatography- tandem mass spectrometry. Surprisingly, low dose CORT (~10 nM) induced spinogenesis, suggesting that low dose CORT may have a neurotrophic effect whereas high dose CORT (~1 μM) under stressful condition has deleterious effects.
|
