The role of Polycomb proteins in the spatial allocation of neocortical area
| Project/Area Number |
23700372
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 大脳皮質 / 神経幹細胞 / ポリコーム / 幹細胞 |
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| Research Abstract |
In this study, we examined whether Polycomb repressor complex regulates the areal organization of a mammalian neocortex. To this end, we conditionally knocked out Ring1B gene, which is an essential component of Polycomb repressor complex, and examined the arealization of the neocortex. We found that Polycomb repressor complex changes the fate of neural stem cells and this fate changes results in the regulation of neocortical arealization.
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Report
(3 results)
Research Products
(21 results)
