The role of Polycomb proteins in the spatial allocation of neocortical area

• Project/Area Number: 23700372
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neuroscience in general
• Research Institution: The University of Tokyo
• Principal Investigator: HIRABAYASHI Yusuke 東京大学, 分子細胞生物学研究所, 助教 (80447391)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 大脳皮質 / 神経幹細胞 / ポリコーム / 幹細胞

Research Abstract

In this study, we examined whether Polycomb repressor complex regulates the areal organization of a mammalian neocortex. To this end, we conditionally knocked out Ring1B gene, which is an essential component of Polycomb repressor complex, and examined the arealization of the neocortex. We found that Polycomb repressor complex changes the fate of neural stem cells and this fate changes results in the regulation of neocortical arealization.

Research Products

• [Journal Article] HMGA regulates the global chromatin stateand neurogenic potential in neocortical precursor cells (2012)
  • Author(s): Kishi, Y., Fujii, Y., Hirabayashi, Y. and Gotoh,Y
  • Journal Title: Nat Neurosci Volume: 15 Pages: 1127-1133
  • Peer Reviewed
• [Journal Article] A noncoding RNA regulates the neurogenin1 gene locus during mouse neocortical development (2012)
  • Author(s): Onoguchi, M., Hirabayashi, Y., Koseki, H. and Gotoh, Y
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 109 Pages: 16939-16944
  • Peer Reviewed
• [Journal Article] PDK1 regulates the generation of oligodendrocyte precursor cells at an early stage of mouse telencephalic development (2012)
  • Author(s): Watatani, K., Hirabayashi, Y., Itoh, Y. and Gotoh, Y
  • Journal Title: Genes Cells Volume: 17 Pages: 326-335
  • Peer Reviewed
• [Journal Article] HMGA regulates the global chromatin state and neurogenic potential in neocortical precursor cells. (2012)
  • Author(s): Kishi, Y.,〓 Fuiii. Y.〓 Hirabayashi, Y. and Gotoh, Y.(〓These authors contributed equally to this work.)
  • Journal Title: Nature Neuroscience Volume: 15 Issue: 8 Pages: 1123-1133
  • DOI: 10.1038/nn.3165
  • Peer Reviewed
• [Journal Article] A noncoding RNA regulates the neurogenin1 gene locus during mouse neocortical development (2012)
  • Author(s): Onoguchi M, Hirabayashi Y, Koseki H, Gotoh Y.
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A. Volume: 109 Issue: 42 Pages: 16939-16944
  • DOI: 10.1073/pnas.1202956109
  • Peer Reviewed
• [Journal Article] PDK1 regulates the generation of oligodendrocyte precursor cells at an early stage of mouse telencephalic development (2012)
  • Author(s): Watatani K, Hirabayashi Y, Itoh Y, Gotoh Y.
  • Journal Title: Genes Cells Volume: 17 Issue: 4 Pages: 326-335
  • DOI: 10.1111/j.1365-2443.2012.01591.x
  • Peer Reviewed
• [Presentation] Masafumi Tsuboi, Haruhiko Koseki and Yukiko Gotoh: Gene Regulation by (2013)
  • Author(s): Yusuke Hirabayashi, Nao Morimoto-Suzki
  • Organizer: Polycomb Group Proteins in the Neocortical Neural Precursor Cells( poster ), Keystone Symposia"Neurogenesis
  • Place of Presentation: Santa Fe, USA
• [Presentation] Gene Regulation by Polycomb Group Proteins in the Neocortical Neural Precursor Cells (2013)
  • Author(s): Hirabayashi Y, Morimoto-Suzki N, Tsuboi M, Koseki H, Gotoh Y.
  • Organizer: Keystone Symposia “Neurogenesis”
  • Place of Presentation: Santa Fe, USA
• [Presentation] Nao Morimoto-Suzki, Masafumi Tsuboi, Haruhiko Koseki, Yutaka Suzuki, Sumio Sugano and Yukiko Gotoh: Gene Regulation by Polycomb Group Proteins in the Neocortical Neural Precursor Cells ( poster ) (2012)
  • Author(s): Yusuke Hirabayashi
  • Organizer: International Symposium on genetic and epigenetic control of cell fate
  • Place of Presentation: グランドプリンスホテル京都
• [Presentation] Wnt シグナルによる大 脳皮質神経幹細胞の運命制御機構 (2012)
  • Author(s): 平林祐介 、小野口真広、桑原篤、徐源江、酒井寛、後藤由季子
  • Organizer: 特定領域 研究「細胞増殖制御」 終了シンポジウム
  • Place of Presentation: くらまえホール(東京)
• [Presentation] Nao Morimoto-Suzki, Masafumi Tsuboi, Haruhiko Koseki and Yukiko Gotoh: Gene Regulation by Polycomb Group Proteins in the Neocortical Neural Precursor Cells( poster ) (2012)
  • Author(s): Yusuke Hirabayashi
  • Organizer: ISSCR 10th Annual Meeting
  • Place of Presentation: Yokohama,Japan
• [Presentation] Nao Morimoto-Suzki, Masafumi Tsuboi, Haruhiko Koseki and Yukiko Gotoh Temporal changes of the Polycomb targets in the neocortical neural precursor cells(poster ) (2012)
  • Author(s): Yusuke Hirabayashi
  • Organizer: The 59th NIBB Conference(1st International Symposium),Neocortical Organization
  • Place of Presentation: Okazaki,Japan
• [Presentation] Gene Regulation by Polycomb Group Proteins in the Neocortical Neural Precursor Cells (2012)
  • Author(s): Hirabayashi Y, Morimoto-Suzki N, Tsuboi M, Koseki H, Gotoh Y.
  • Organizer: ISSCR 10th Annual Meeting
  • Place of Presentation: Yokohama
• [Presentation] Gene Regulation by Polycomb Group Proteins in the Neocortical Neural Precursor Cells (2012)
  • Author(s): Hirabayashi Y, Morimoto-Suzki N, Tsuboi M, Koseki H, Suzuki Y, Sugano S, Gotoh Y.
  • Organizer: International Symposium on genetic and epigenetic control of cell fate
  • Place of Presentation: Kyoto
• [Presentation] Wntシグナルによる大脳皮質神経幹細胞の運命制御機構 (2012)
  • Author(s): 平林祐介、小野口真広、桑原篤、徐源江、酒井 寛、後藤由季子
  • Organizer: 特定領域研究「細胞増殖制御」終了シンポジウム
  • Place of Presentation: 東京
  • Invited
• [Presentation] Temporal changes of the Polycomb targets in the neocortical neural precursor cells (2012)
  • Author(s): Yusuke Hirabayashi, Nao Morimoto-Suzki, Masafumi Tsuboi andYukiko Gotoh
  • Organizer: 東京大学グローバルCOEリトリート
  • Place of Presentation: 八ヶ岳ロイヤルホテル（山梨県北杜市）
• [Presentation] Temporal changes of the Polycomb targets in the neocortical neural precursor cells (2012)
  • Author(s): Yusuke Hirabayashi, Nao Morimoto-Suzki, Masafumi Tsuboi, Haruhiko Koseki and Yukiko Gotoh
  • Organizer: The 59th NIBB Conference(1st International Symposium), Neocortical Organization
  • Place of Presentation: Okazaki, Japan
• [Presentation] Nao Morimoto-Suzki, Masafumi Tsuboi, Haruhiko Koseki and Yukiko Gotoh Gene regulation by polycomb group proteins in the neocortical neural precursor cells ( poster ) (2011)
  • Author(s): Yusuke Hirabayashi
  • Organizer: Joint CSH Asia/ISSCR Conference on CellularPrograms & Reprogramming
  • Place of Presentation: Suzhou, China
• [Presentation] Gene regulation by polycomb group proteins in the neocortical neural precursor cells (2011)
  • Author(s): Yusuke Hirabayashi, Nao Morimoto-Suzki, Masafumi Tsuboi, Haruhiko Koseki and Yukiko Gotoh
  • Organizer: "Joint CSH Asia/ISSCR Conference on Cellular Programs & Reprogramming"
  • Place of Presentation: Suzhou, China
• [Presentation] ポリコーム群タンパク質による大脳皮質神経系前駆細胞の分化運命制御
  • Author(s): 平林祐介、森本菜央、小野口真広、壷井將史、後藤由季子
  • Organizer: 新学術領域「多方向かつ段階的に進行する細胞分化における運命決定メカニズムの解明」第二回領域班会議
  • Place of Presentation: 軽井沢プリンスホテル（長野県軽井沢町
• [Remarks]
  • URL: http://www.iam.u-tokyo.ac.jp/celltech/