Elucidation of the Mechanisms that Netrin-1 Guides Commissural Axons to the Ventral Midline

• Project/Area Number: 23700379
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neuroscience in general
• Research Institution: Osaka University
• Principal Investigator: YAMAUCHI Kenta 大阪大学, 生命機能研究科, 特任研究員 (00513079)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 軸索誘導 / 交連軸索 / ネトリン1 / 化学走性説 / 軸索ガイダンス / ネトリン１

Research Abstract

Chemotropism is a fundamental theory of axon guidance. However, this theory has not been rigorously tested. In this study , I studied whether netrin-1 guides commissural axons ventrally in a chemotrophic manner. Expression patterns of netrin-1 mRNA and protein during ventral migration of commissural axons were examined. Additionally , which netrin-1 expression is necessary and sufficient for ventrally directed extension of commissural axons was tested.

Research Products

• [Journal Article] Role of neuropilin-2 in the ipsilateral growth of midbrain dopaminergic axons (2013)
  • Author(s): Makio Torigoe, Kenta Yamauchi, Atsushi Tamada, Ikuo Matsuda, Atsu Aiba, Valérie Castellani, Fujio Murakami
  • Journal Title: Eur J Neurosci. Volume: 37 Issue: 10 Pages: 1573-83
  • DOI: 10.1111/ejn.12190
  • Peer Reviewed
• [Journal Article] Excitatory cortical neurons with multipolar shape establish neuronal polarity by forming a tangentially oriented axon in the intermediate zone (2013)
  • Author(s): Yumiko Hatanaka, Kenta Yamauchi
  • Journal Title: Cerebral Cortex Volume: (印刷中) Issue: 1 Pages: 105-113
  • DOI: 10.1093/cercor/bhr383
  • Peer Reviewed
• [Journal Article] Temporally- and spatially regulated generation of distinct descendants by sonic hedgehog-expressing progenitors in the forebrain (2012)
  • Author(s): Wada Y, Yamauchi K, Murakami F, Tanabe Y
  • Journal Title: Dev Neurobiol Volume: 72 Issue: 8 Pages: 1099-113
  • DOI: 10.1002/dneu.20861
  • Peer Reviewed
• [Journal Article] Formation of axon-dendrite polarity in situ: Initiation of axons from polarized and non-polarized cells (2012)
  • Author(s): Yumiko Hatanaka, Kenta Yamauchi, and Fujio Murakami
  • Journal Title: Development, Growth & Differentiation Volume: 54 Issue: 3 Pages: 398-407
  • DOI: 10.1111/j.1440-169x.2012.01344.x
  • NAID: 10031136912
  • Peer Reviewed
• [Presentation] Role of neuropilin-2 signaling in the ipsilateral growth of midbrain dopaminergic axons. (2012)
  • Author(s): Torigoe M, Yamauchi K, Tamada A, Matsuda I, Aiba A, Castellani V, Murakami F.
  • Organizer: SfN's 42nd annual meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-10-17
• [Presentation] Netrin-1 Is a Determinant of Commissural Axon Growth within the CNS. (2012)
  • Author(s): Yamauchi K, Yamazaki M, Sakimura K, Umebayashi M, Murakami F.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2012-09-18
• [Presentation] Role of neuropilin-2 signaling in the ipsilateral growth of midbrain dopaminergic axons (2012)
  • Author(s): Torigoe M, Yamauchi K, Tamada A, Matsuda I, Aiba A, Castellani V, Murakami F.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2012-09-18
• [Presentation] Cortical excitatory neuron are divided into two distinct groups by their initial projection patterns. (2012)
  • Author(s): Hatanaka Y, Yamauchi K, Namikawa T, Kawaguchi Y.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2012-09-18
• [Presentation] Netrin-1 Is a Determinant of Commissural Axon Growth within the CNS (2012)
  • Author(s): Yamauchi K, Yamazaki M, Sakimura K, Umebayashi M, Murakami F
  • Organizer: 第３５回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Role of neuropilin-2 signaling in the ipsilateral growth of midbrain dopaminergic axons (2012)
  • Author(s): Torigoe M, Yamauchi K, Tamada A, Matsuda I, Aiba A, Castellani V, Murakami F
  • Organizer: 第３５回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Cortical excitatory neuron are divided into two distinct groups by their initial projection patterns (2012)
  • Author(s): Hatanaka Y, Yamauchi K, Namikawa T, Kawaguchi Y
  • Organizer: 第３５回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Role of neuropilin-2 signaling in the ipsilateral growth of midbrain dopaminergic axons (2012)
  • Author(s): Torigoe M, Yamauchi K, Tamada A, Matsuda I, Aiba A, Castellani V, Murakami F
  • Organizer: SfN’s 42nd annual meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] Excitatory cortical neurons with multipolar shape establish neuronal polarity by forming a tangentially oriented axon in the intermediate zone. (2011)
  • Author(s): Hatanaka Y, Yamauchi K.
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-09-16
• [Presentation] Excitatory cortical neurons with multipolar shape establish neuronal polarity by forming a tangentially oriented axon in the intermediate zone (2011)
  • Author(s): 畠中 由美子, 山内 健太
  • Organizer: 第３４回日本神経科学大会
  • Place of Presentation: 横浜