| Project/Area Number |
23700390
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | G タンパク質共役型受容体 / シナプス可塑性 / 小脳長期抑圧 / 代謝型グルタミン酸受容体 / Gタンパク質共役型受容体 / アデノシン受容体 / FRET / 運動学習 / 小脳 / ライブセル・イメージング / 長期抑圧 |
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| Research Abstract |
In various cell types, G protein-coupled receptors (GPCRs) form heteromeric complexes and cooperatively mediate the intrigue cellular responses.Although heteromeric GPCR complexes are suggested to occur in many neurons, their contribution to neuronal function remains unclear. We address this question using two GPCRs expressed in cerebellar Purkinje cells: adenosine A1 receptor, which regulates neurotransmitter release and neuronal excitability in central neurons and type -1 metabotropic glutamate receptor, which mediates cerebellar long-term depression, a form of synaptic plasticity crucial for cerebellar motor learning.
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