| Project/Area Number |
23700395
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
KURUSU Mitsuhiko 国立遺伝学研究所, 構造遺伝学研究センター, 助教 (50413985)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Emiko 国立遺伝学研究所, 構造遺伝学研究センター, 准教授 (20173891)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | FGF / シナプス / 神経筋接合部 / ショウジョウバエ / 神経 |
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| Research Abstract |
Although FGF signaling has been known to induce presynaptic differentiation in mammalian synaptic development, it remains unclear whether FGF signaling has a role in postsynaptic development. Here we report that Drosophila FGF signaling is required for the postsynaptic development of neuromuscular junctions. Two Drosophila FGF ligands, Pyramus and Thisbe, are expressed in neurons and muscles and a FGF receptor, Heartless, is localized in close proximity to postsynaptic GluRIIA clusters. Mutant analyses found that FGF signaling positively regulates G1uRI1A localization on postsynaptic sites. Moreover, GluRIIA expression is also controlled transcriptionally by FGF signaling. These results suggest that Drosophila FGF signaling is a regulator of Glutamate receptor expression in postsynaptic NMJ development.
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