| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
REM (rapid eye movement) sleep is a phenomenon unique to certain vertebrate animal species and is thus expected to be involved in higher-order brain functions. We identified neurons in the brainstem that regulate transitions between REM and non-REM sleep. Furthermore, we identified genes that are expressed in a neuron-subtype selective manner in these neurons. Furthermore, using promoters of these genes, we could efficiently manipulate REM sleep. In addition, we showed that the vertebrate-specific synaptic protein netrin-G1 is involved in regulation of REM sleep. These results are expected to contribute to understanding the mechanism of REM sleep regulation, and may also provide a powerful tool for addressing the function of REM sleep.
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