| Project/Area Number |
23700412
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経軸索ガイダンス分子 / ネトリン / Unc5 / FLRT / 軸索ガイダンス分子 / FLRTファミリー / 国際研究者交流 / ドイツ / 国際情報交換 / 国際情報交流 / ミュンヘン |
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| Research Abstract |
The mammalian Unc5 family of repulsive Netrin receptors comprises four orthologues (Unc5A-D) whose functions are not well understood. In the developing neocortex, a subpopulation of neurons in the subventricular zone (SVZ) characterized by the expression of Unc5D, displays delayed migration to the cortical plate (CP). However, the underlying mechanism of this behavior is unknown. Unc5D was shown to bind Fibronectin and leucine-rich transmembrane protein-3 (FLRT3), the relevance of which is unclear. We show that FLRT2, which is expressed in the CP, is a new ligand for Unc5D. In FLRT2 or Unc5D mutants, a subpopulation of SVZ neurons shows premature migration towards the CP, whereas Unc5D overexpression has opposite effects. These findings suggest that FLRT2 represents a repulsive guidance cue that causes Unc5D+ neurons to reside in the SVZ for a prolonged period before initiating migration.
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