| Project/Area Number |
23700415
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
|
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| Research Institution | Kanazawa University (2013)
Osaka University (2011-2012) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | オリゴデンドロサイト / 精神疾患 / 統合失調症 / 脳発達障害 / DISC1 / グリア細胞 / 脳発達 / DBZ / 細胞分化 / 発達障害 / 遺伝子 / 脳神経発達 |
|---|
| Research Abstract |
In this study, we found that DISC1, a kind of gene related with mental illness, regulates development of oligodendrocytes by controlling expression level of Sox10 and Nkx2.2. Furthermore, we found that DBZ, a binding-partner of DISC1, also regulates development of oligodendrocytes in vitro and in vivo. These results suggest that abnormal development of oligodendrocytes may be involved in mechanisms of developing mental illness.
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