Functional analysis of mental illness related genes in oligodendrocytes

• Project/Area Number: 23700415
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kanazawa University (2013); Osaka University (2011-2012)
• Principal Investigator: TSUYOSHI Hattori 金沢大学, 医学系, 助教 (50457024)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: オリゴデンドロサイト / 精神疾患 / 統合失調症 / 脳発達障害 / DISC1 / グリア細胞 / 脳発達 / DBZ / 細胞分化 / 発達障害 / 遺伝子 / 脳神経発達

Research Abstract

In this study, we found that DISC1, a kind of gene related with mental illness, regulates development of oligodendrocytes by controlling expression level of Sox10 and Nkx2.2. Furthermore, we found that DBZ, a binding-partner of DISC1, also regulates development of oligodendrocytes in vitro and in vivo. These results suggest that abnormal development of oligodendrocytes may be involved in mechanisms of developing mental illness.

Research Products

• [Journal Article] Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury. (2014)
  • Author(s): Takarada-Iemata M, Kezuka D, Takeichi T, Ikawa M, Hattori T, Kitao Y, Hori O.
  • Journal Title: J Neurochem. Volume: 印刷中 Issue: 3 Pages: 374-87
  • DOI: 10.1111/jnc.12729
  • NAID: 120005478796
  • Peer Reviewed
• [Journal Article] DISC1 (disrupted-in-schizophrenia-1) regulates differentiation of oligodendrocytes. (2014)
  • Author(s): Hattori T, Shimizu S, Koyama Y, Emoto H, Matsumoto Y, Kumamoto N, Yamada K, Takamura H, Matsuzaki S, Katayama T, Tohyama M, Ito A.
  • Journal Title: PLoS One Volume: 7;9(2) Issue: 2 Pages: e88506-e88506
  • DOI: 10.1371/journal.pone.0088506
  • Peer Reviewed
• [Journal Article] DBZ, a CNS-specific DISC1 binding protein, positively regulates oligodendrocyte differentiation. (2014)
  • Author(s): Shimizu S, Koyama Y, Hattori T, Tachibana T, Yoshimi T, Emoto H, Matsumoto Y, Miyata S, Katayama T, Ito A, Tohyama M.
  • Journal Title: Glia. Volume: 62(5) Issue: 5 Pages: 709-724
  • DOI: 10.1002/glia.22636
  • Peer Reviewed
• [Journal Article] XLMR protein related to neurite extension (Xpn/KIAA2022) regulates cell-cell and cell-matrix adhesion and migration (2013)
  • Author(s): Magome T, Hattori T, Taniguchi M, Ishikawa T, Miyata S, Yamada K, Takamura H, Matsuzaki S, Ito A, Tohyama M, Katayama T
  • Journal Title: Neurochemistry International Volume: 63 Issue: 6 Pages: 561-569
  • DOI: 10.1016/j.neuint.2013.09.011
  • Peer Reviewed
• [Journal Article] DBZ (DISC1-binding zinc finger protein)-deficient mice display abnormalities in basket cells in the somatosensory cortices. (2013)
  • Author(s): Koyama Y, Hattori T, Shimizu S, Taniguchi M, Yamada K, Takamura H, Kumamoto N, Matsuzaki S, Ito A, Katayama T, Tohyama M.
  • Journal Title: J Chem Neuroanat. Volume: 53 Pages: 1-10
  • DOI: 10.1016/j.jchemneu.2013.07.002
  • Peer Reviewed
• [Journal Article] TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression. (2012)
  • Author(s): Takamura H, Koyama Y, Matsuzaki S, Yamada K, Hattori T, Miyata S, Takemoto K, Tohyama M, Katayama T.
  • Journal Title: PLoS One Volume: 7 Issue: 12 Pages: 12-12
  • DOI: 10.1371/journal.pone.0051912
  • Peer Reviewed
• [Journal Article] Transient expression of Xpn, an XLMR protein related to neurite extension, during brain development and participation in neurite outgrowth. (2012)
  • Author(s): Ishikawa T, Miyata S, Koyama Y, Yoshikawa K, Hattori T, Kumamoto N, Shingaki K, Katayama T, Tohyama M.
  • Journal Title: Neuroscience Volume: 214 Pages: 181-91
  • DOI: 10.1016/j.neuroscience.2012.04.030
  • Peer Reviewed
• [Presentation] oligodendrocyte分化における精神疾患リスク因子DISC1の機能解析 (2013)
  • Author(s): 服部剛志
  • Organizer: 解剖学会中部地方会
  • Place of Presentation: 甲府
  • Year and Date: 2013-10-05
• [Presentation] Analysis of Cortical Development in Mice Lacking DBZ、ポスター発表 (2013)
  • Author(s): 服部剛志
  • Organizer: ISN-ASN 2013
  • Place of Presentation: メキシコ、カンクン
  • Year and Date: 2013-04-22
• [Presentation] 精神疾患リスク因子DISC1はオリゴデンドロサイトの分化を制御する, 口頭発表 (2012)
  • Author(s): 服部剛志
  • Organizer: 第17回グリア研究会
  • Place of Presentation: 神戸
  • Year and Date: 2012-10-02
• [Presentation] DBZdeficientmicedisplay abnormal development of cortical interneurons and altered emotionalbehavior, ポスター発表 (2012)
  • Author(s): 服部剛志
  • Organizer: 第55回日本神経化学大会
  • Place of Presentation: 神戸
  • Year and Date: 2012-09-30
• [Presentation] DISC1 regulates oligodendrocyte differentiation, ポスター発表 (2012)
  • Author(s): 服部剛志
  • Organizer: 第55回日本神経化学大会
  • Place of Presentation: 神戸
  • Year and Date: 2012-09-30
• [Presentation] Roles of DISC1-interacting partner DBZ in developingbrain (2012)
  • Author(s): 服部剛志
  • Organizer: 第35回日本神経科学会大会
  • Place of Presentation: 名古屋シンポジウム講演
  • Year and Date: 2012-09-19
• [Presentation] 精神疾患リスク因子DISC1はオリゴデンドロサイトの分化を制御する (2012)
  • Author(s): 服部 剛志、清水 尚子、伊藤 彰、片山 泰一、小山 佳久、遠山 正彌
  • Organizer: 第17回グリア研究会
  • Place of Presentation: 神戸国際会議場
• [Presentation] DISC1 regulates oligodendrocyte differentiation (2012)
  • Author(s): Hattori, T., Shimizu, S., Koyama, Y., Taniguchi, M.,Katayama, T., Ito, A. and Tohyama, M.
  • Organizer: 第55回日本神経化学大会
  • Place of Presentation: 神戸国際会議場
• [Presentation] 精神疾患リスク因子DISC1のオリゴデンドロサイト分化への影響、口頭発表 (2011)
  • Author(s): 服部剛志
  • Organizer: 第16回グリア研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-20
• [Presentation] A ROLE OF DISC1 IN GLIALCELLS, ポスター発表 (2011)
  • Author(s): 服部剛志
  • Organizer: 第34回神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] ANALYSIS OF CORTICAL DEVELOPMENT IN MICE LACKING DBZ, ポスター発表 (2011)
  • Author(s): 服部剛志
  • Organizer: ISN-ESN 2011
  • Place of Presentation: ギリシャ・アテネ
  • Year and Date: 2011-08-31
• [Presentation] 大脳皮質構築における新規因子DBZの機能解析, ポスター発表 (2011)
  • Author(s): 服部剛志
  • Organizer: 新学術領域夏の班会議
  • Place of Presentation: 神戸
  • Year and Date: 2011-08-21
• [Presentation] ANALYSIS OF CORTICAL DEVELOPMENT IN MICE LACKING DBZ (2011)
  • Author(s): 服部 剛志
  • Organizer: ISN-ESN 2011
  • Place of Presentation: Megaron Athens International Conference Center（ギリシャ・アテネ）
• [Presentation] A ROLE OF DISC1 IN GLIAL CELLS (2011)
  • Author(s): 服部 剛志
  • Organizer: 第34回神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] 精神疾患リスク因子DISC1のオリゴデンドロサイト分化への影響 (2011)
  • Author(s): 服部 剛志
  • Organizer: 第16回グリア研究会
  • Place of Presentation: ウインク愛知（愛知県）
• [Presentation] oligodendrocyte 分化における精神疾患リスク因子 DISC1 の機能解析
  • Author(s): 服部 剛志
  • Organizer: 解剖学会 中部地方会
  • Place of Presentation: 山梨大学（甲府）
• [Book] Psychosis and adhesion molecules. Mental Illnesses Understanding, Prediction and Control1 (2011)
  • Author(s): Hattori, T., Miyata, S., Ito, A., Katayama, T., & Tohyama, M.
  • Total Pages: 459
  • Publisher: In Tech
• [Book] 脳21 (2011)
  • Author(s): 服部剛志
  • Total Pages: 250
  • Publisher: 金芳堂
• [Book] Mental Illness (2011)
  • Author(s): 服部 剛志、宮田 信吾、伊藤 彰、片山 泰一、遠山 正彌
  • Total Pages: 458
  • Publisher: InTech
• [Remarks]
  • URL: http://med03.w3.kanazawa-u.ac.jp/
• [Patent(Industrial Property Rights)] 精神神経系疾患モデル非ヒト動物及びその用途 (2011)
  • Inventor(s): 服部剛志、遠山正彌、松崎伸介、片山泰一、伊藤彰
  • Industrial Property Rights Holder: 服部剛志、遠山正彌、松崎伸介、片山泰一、伊藤彰
  • Industrial Property Rights Type: 特許
  • Filing Date: 2011-07-27
• [Patent(Industrial Property Rights)] 精神神経系疾患モデル非ヒト動物及びその用途 (2011)
  • Inventor(s): 服部 剛志、遠山 正彌、松崎 伸介、片山 泰一、伊藤 彰
  • Industrial Property Rights Holder: 服部 剛志、遠山 正彌、松崎 伸介、片山 泰一、伊藤 彰
  • Filing Date: 2011