The analyses of molecular mechanisms that regulate brain cortical development
| Project/Area Number |
23700417
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 発生 / 神経細胞 / 移動 / リーリン / 層構造 / 大脳 / 海馬 / 新皮質 / 大脳皮質 / 細胞移動 / マウス / 神経細胞移動 / 子宮内胎児電気穿孔法 / RNAi法 |
|---|
| Research Abstract |
In this study we revealed that the outermost region of the developing mouse cortical plate has histologically distinct features and named this region the primitive cortical zone (PCZ). Then we used in utero electroporation technique to analyze the function of various molecules and showed that Reelin activates integrin through the intracellular signaling pathway. This intracellular pathway is required for neurons to enter the PCZ. Moreover, we analyzed the migratory profile of neurons in the developing mouse hippocampal CA1 region and found that the hippocampal pyramidal neurons migrate by a unique mode of migration.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin-receptors, ApoER2 or VLDLR, in neurons.2013
Author(s)
T.Fuchigami, Y.Sato1, Y.Tomita1, T.Takano, S.Miyauchi, Y.Tsuchiya, T.Saito, K.Kubo, K.Nakajima, M.Fukuda, M.Hattori, and S.Hisanaga
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Journal Title
Genes to Cells
Volume: in press
Issue: 5
Pages: 410-424
DOI
Related Report
Peer Reviewed
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[Journal Article] DISC1-dependent switch from progenitor proliferation to migration in the developing cortex2011
Author(s)
Ishizuka K, Kamiya A, Oh EC, Kanki H, Seshadri S, Robinson JF, Murdoch H, Dunlop AJ, Kubo K, Furukori K, Huang B, Zeledon M, Hayashi-Takagi A, Okano H, Nakajima K, Houslay MD, Katsanis N, Sawa A
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Journal Title
Nature
Volume: 473(7345)
Issue: 7345
Pages: 92-6
DOI
Related Report
Peer Reviewed
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[Presentation]2013
Author(s)
Yuki Hirota, Ken-ichiro Kubo, Kazunori Nakajima
Organizer
The 25th CDB Meeting "Cilia and Centrosomes, 20130617-20130618, from Fertilization to Cancer
Place of Presentation
RIKEN CDB,神戸
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