Neural circuit mechanisms underlying behavioral transition from attack to parenting in male mice.
| Project/Area Number |
23700420
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TACHIKAWA Kashiko 独立行政法人理化学研究所, シナプス分子機構研究チーム, 研究員 (70424182)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 父性行動 / 養育行動 / 鋤鼻器 / フェロモン / 攻撃行動 / c-Fos |
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| Research Abstract |
We found that chemical cues evoking pup-directed aggression are received by the vomeronasal sensory neurons and activate the vomeronasal neural pathway in sexually-naive male mice but not in fathers. In addition surgical ablation of the vomeronasal organ in sexually-naive males resulted in the abrogation of pup-directed aggression and simultaneous induction of parental behavior. Thus the down-regulation of pup pheromone-induced activation of the vomeronasal system might be important for the behavioral transition from attack to parenting in male mice.
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Report
(3 results)
Research Products
(7 results)
