| Project/Area Number |
23700426
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Keio University |
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Principal Investigator |
KISHI Noriyuki 慶應義塾大学, 医学部, 特任助教 (30594882)
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| Research Collaborator |
OKANO Hideyuki 慶應義塾大学, 医学部, 教授 (60160694)
OKUNO Misako 慶應義塾大学, 医学部, 研究員
JEFFREY D. Macklis ハーバード大学, 医学部, 教授
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脳発達障害 / レット症候群 / 自閉症 / MeCP2 / NF-ｋBシグナル / PCRアレイ / NF-kBシグナル |
|---|
| Research Abstract |
In this research project, we investigated the involvement of NF-kB signaling in the pathogenesis of Mecp2-null mice by PCR array analysis. Using PCR arrays that consisted of 84 NF-kB signaling-related genes, we compared gene expression profiles between wi
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