| Project/Area Number |
23700428
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Doshisha University |
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Principal Investigator |
URANO Yasuomi (2012) 同志社大学, 生命医科学部, 助教 (22546674)
浦野 泰臣 同志社大学, 生命医科学部, 助教 (00546674)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アルツハイマー病 / 脂質代謝 / 酸化コレステロール / 細胞内輸送 / 酸化ステロール |
|---|
| Research Abstract |
A major pathological hallmark of Alzheimer’s disease is the accumulation of Amyloid ? (A?) in senile plaques. A? is generated from Amyloid precursor protein (APP). In this study, I found that the treatment with 24S-hydroxycholesterol, which is the brain-specific oxysterol, induced the expression of GRP78, an ER chaperone, through unfolded protein response pathways, and enhanced the formation of the APP/GRP78 complex. Thereby, 24S-hydroxycholesterol downregulates intracellular APP trafficking, resulting in the reduction of A? production.
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