| Project/Area Number |
23700431
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
ONO Maiko 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (70595876)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | タウ / p62 / 選択的オートファジー / 神経細胞死 / アルツハイマー病 / 神経原線維変化 |
|---|
| Research Abstract |
In Alzheimer’s disease, cytotoxicity exerted by abnormal tau is considered to be one of the main causes of neuronal death. Results from the present study indicate that selective autophagy and p62, a ubiquitinated cargo receptor mediating selective autophagy, are closely involved in neuronal death provoked by abnormal tau. p62 exerted neuroprotection against tau pathologies by eliminating nonfibrillar hyperphosphorylated tau species and sequestering hyperphosphorylated tau into cell bodies. Moreover, our findings suggested that insufficient capacity of p62 for processing of abnormal tau induces neuron death under tau accumulation.
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