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Identification of regulators of biogenic amine signaling in C. elegans

Research Project

Project/Area Number 23700439
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionThe University of Tokyo

Principal Investigator

SUO Satoshi  東京大学, 大学院・総合文化研究科, 助教 (20596845)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords神経伝達物質 / 受容体 / モデル生物 / ドーパミン / オクトパミン / ニューロペプチド / C. elegans / 遺伝学
Research Abstract

Biogenic amine neurotransmitters, such as dopamine, noradrenaline, and serotonin, play important roles in regulating behaviors and metabolism of animals. In this study, we used a model animal Caenorhabditis elegans to identify novel factors that regulate amine signaling and found that neuropeptide signaling regulates amine signaling. We also identified and characterized an amine neurotransmitter involved in this signaling.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (14 results)

  • [Journal Article] Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by γ-secretase complex2012

    • Author(s)
      長柄雄介
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 417 Issue: 1 Pages: 462-467

    • DOI

      10.1016/j.bbrc.2011.11.140

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alternative splicing of PDLIM3/ALP, for α-actinin-associated LIM protein 3, is aberrant in persons with myotonic dystrophy2011

    • Author(s)
      大澤菜摘
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 409 Issue: 1 Pages: 64-69

    • DOI

      10.1016/j.bbrc.2011.04.106

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of rice-expressed amyloid ss in the Tg2576 Alzheimer's disease transgenic mouse model2011

    • Author(s)
      Nojima J, Maeda A, Aoki S, Suo S, Yanagihara D, Watanabe Y, Yoshida T, Ishiura S
    • Journal Title

      Vaccine

      Volume: 29 Issue: 37 Pages: 6252-6258

    • DOI

      10.1016/j.vaccine.2011.06.073

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ドー パミンとオクトパミンによる線虫 C. elegans の体のサイズ制御2012

    • Author(s)
      大網栄太郎、周防諭、石浦章一
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2012-12-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Bioamine- regulation of acetylcholine signaling in C. elegans2012

    • Author(s)
      周防諭 、石浦章一
    • Organizer
      East Asia C. elegans Meeting
    • Place of Presentation
      剣潭海外青年活動センター、台北、台湾
    • Year and Date
      2012-06-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Dopamine regulates the body length in C. elegans2012

    • Author(s)
      大網栄太郎、周防諭 、石浦章一
    • Organizer
      East Asia C. elegans Meeting
    • Place of Presentation
      剣潭海外青年活動センター、台北、台湾
    • Year and Date
      2012-06-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of starvation-mediated signaling that requires two Gq-coupled octopamine receptors in C. elegans2012

    • Author(s)
      吉田碧、周防諭 、石浦章一
    • Organizer
      East Asia C. elegans Meeting
    • Place of Presentation
      剣潭海 外青年活動センター、台北、台湾
    • Year and Date
      2012-06-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Bioamine-regulation of acetylcholine signaling in C. elegans.2012

    • Author(s)
      周防諭
    • Organizer
      East Asia C. elegans Meeting
    • Place of Presentation
      台北、台湾
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analysis of starvation-mediated signaling that requires two Gq-coupled octopamine receptors in C. elegans.2012

    • Author(s)
      吉田碧
    • Organizer
      East Asia C. elegans Meeting
    • Place of Presentation
      台北、台湾
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dopamine regulates the body length in C. elegans.2012

    • Author(s)
      大網栄太郎
    • Organizer
      East Asia C. elegans Meeting
    • Place of Presentation
      台北、台湾
    • Related Report
      2012 Annual Research Report
  • [Presentation] ドーパミンとオクトパミンによる線虫C. elegansの体のサイズ制御2012

    • Author(s)
      大網栄太郎
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dopamine and octopamine regulate acetylcholine signaling in C. elegans2011

    • Author(s)
      周防諭 、石浦章一
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2011-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Dopamine regulates the body length through two dopamine receptors in C.elegans2011

    • Author(s)
      大網栄太郎、周防諭 、石浦章一
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2011-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] C. elegans における 2 種の Gq 共役型オクトパミン受容 体を必要とする飢餓依存的なシグナル伝達の解析2011

    • Author(s)
      吉田碧、周防諭、石浦章一
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2011-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Dopamine and octopamine regulate acetylcholine signaling in C. elegans2011

    • Author(s)
      周防 諭
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜パシフィコ
    • Related Report
      2011 Research-status Report
  • [Presentation] Dopamine regulates the body length through two dopamine receptors in C. elegans2011

    • Author(s)
      大網 栄太郎
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜パシフィコ
    • Related Report
      2011 Research-status Report
  • [Presentation] C. elegansにおける2種のGq共役型オクトパミン受容体を必要とする飢餓依存的なシグナル伝達の解析2011

    • Author(s)
      吉田 碧
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜パシフィコ
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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