| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Brain injury is known to activate astrocytes, however, it is unclear how they are regulated to show an oriented response to the focal brain injury. Here we demonstrate that down-regulation in astrocytic P2Y1 receptor accelerates astrocyte responses and neuroprotection after brain injury. Inhibition or knockout of P2Y1 receptor accelerated astrocyte reaction in vitro. P2Y1 receptor knockout (P2Y1KO) mouse showed accelerated astrocyte activation at early phase after brain injury and reduced a number of dead neurons which were reproduced by selective knockout of P2Y1 receptor in astrocytes. Our data highlight P2Y1 receptor-mediated-astrocyte reaction after brain injury that is essential for neuroprotective action.
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