Regulation of energy metabolism by necdin-Sirt1 complex
| Project/Area Number |
23700445
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | エネルギー代謝 / アセチル化 / 視床下部 / 脳・神経 / 脳神経疾患 / Sirt1 |
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| Research Abstract |
I examined the regulation of energy metabolism-related factors by necdin-Sirt1 complex. Necdin-Sirt1 complex controlled Foxo1 acetylation and neuropeptide gene expression to modulate the hypothalamic-pituitary-thyroid axis. I also found necdin regulates the mitochondrial biogenesis and function.
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Report
(3 results)
Research Products
(26 results)
