Chromatin Dynamics Associated with Neuronal Differentiation
| Project/Area Number |
23700447
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
SUGO Noriyuki 大阪大学, 大学院・生命機能研究科, 助教 (20372625)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 発生・分化・老化 / DNA 修復 / 1分子生理・生化学 / 神経科学 / 脳・神経 / 発生・分化 / 発現制御 / ナノバイオ |
|---|
| Research Abstract |
Neuronal differentiation during cortical development is regulated by dynamics of chromatin containing DNA and transcription factors. Here we examined spatiotemporalinteractions between fluorescent-tagged transcription factors and their target sites in living cells using single-molecule imaging techniques. The transcription factor binding to its target sequences showed longer residence time compared to that binding to unrelated sequences in the nucleus.
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Report
(3 results)
Research Products
(14 results)
