Interaction between calcium dynamics and actin skeleton on methamphetamine-induced rewarding effects

• Project/Area Number: 23700453
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Hoshi University
• Principal Investigator: SHIBASAKI Masahiro 星薬科大学, 薬学部, 助教 (80412162)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 覚せい剤 / 神経可塑性 / カルシウム動態 / アクチン骨格 / シナプス形成

Research Abstract

METH-conditioning significantly increased the protein levels ofADF, synaptophysin and PSD95 including the enhancement of actin turnover. In addition,increased acetylation of histone H3 was found in specific gene-promoter regions relatedto synaptic plasticity, such as synaptophysin and PSD95 showing METH-induced placepreference. These findings indicate that interaction between calcium dynamics and actinskeleton are important to the methamphetamine-induced rewarding effects.

Research Products

• [Journal Article] Involvement of the K+ -Cl- co-transporter KCC2 in the sensitization to morphine-induced hyperlocomotion under chronic treatment with zolpidem in the mesolimbic system. (2013)
  • Author(s): Shibasaki M, Masukawa D, Ishii K, Yamagishi Y, Mori T, Suzuki T.
  • Journal Title: J Neurochem Volume: (in press)
  • Peer Reviewed
• [Journal Article] Effect of chronic ethanol treatment on mu-opioid receptor function, interacting proteins and morphine-induced place preference. (2013)
  • Author(s): Shibasaki M, Watanabe K, Takeda K, ItohT, Tsuyuki T, Narita M, Mori T, Suzuki T.
  • Journal Title: Psychopharmacology (Berl) Volume: (in press)
  • Peer Reviewed
• [Journal Article] Effect of chronic ethanol treatment on mu-opioid receptor function, interacting proteins and morphine-induced place preference. (2013)
  • Author(s): Shibasaki M, Watanabe K, Takeda K, Itoh T, Tsuyuki T, Narita M, Mori T, Suzuki T.
  • Journal Title: Psychopharmacology Volume: in press
  • Peer Reviewed
• [Journal Article] Inhibitory effects of SA4503 on the rewarding effects of abused drugs. (2013)
  • Author(s): Mori T, Rahmadi M, Yoshizawa K, Itoh T, Shibasaki M, Suzuki T.
  • Journal Title: Addict Biol Volume: in press Issue: 3 Pages: 362-369
  • DOI: 10.1111/j.1369-1600.2012.00488.x
  • Peer Reviewed
• [Journal Article] Actin dynamics in development of behavioral sensitization after withdrawal from long-term ethanol administration to mice. (2012)
  • Author(s): Shibasaki M, Kurokawa K, Mizuno K, Suzuki T, Ohkuma S.
  • Journal Title: Alcohol Clin Exp Res Volume: 36(8) Pages: 1385-1396
  • Peer Reviewed
• [Journal Article] Effect of aripiprazole on anxiety associated with ethanol physical dependence and on ethanol-induced place preference. (2012)
  • Author(s): Shibasaki M, Kurokawa K, Mizuno K, Ohkuma S
  • Journal Title: J Pharmacol Sci Volume: 118(2) Pages: 215-224
  • NAID: 10030454888
  • Peer Reviewed
• [Journal Article] Inhibitory effects of SA4503 on the rewarding effects of abused drugs. (2012)
  • Author(s): Mori T, Rahmadi M, Yoshizawa K, Itoh T, Shibasaki M, Suzuki T.
  • Journal Title: Addict Biol
  • Peer Reviewed
• [Journal Article] Effects of dronabinol on morphine-induced dopamine-related behavioral effects in animals (2012)
  • Author(s): Mori T, Shibasaki M, Abe M, Udagawa Y, Suzuki
  • Journal Title: Synapse Volume: 66(11) Pages: 931-937
  • Peer Reviewed
• [Journal Article] Olanzapine suppresses the rewarding and discriminative stimulus effects induced by morphine. (2012)
  • Author(s): Torigoe K, Mori T, Shibasaki M, Yoshizawa K, Narita M, Suzuki T
  • Journal Title: Synapse Volume: 66(2) Pages: 174-179
  • Peer Reviewed
• [Journal Article] Regulation of type 1 inositol 1,4,5-triphosphate receptor by dopamine receptors in cocaine-induced place conditioning. (2012)
  • Author(s): Kurokawa K, Mizuno K, Shibasaki M, Ohkuma S
  • Journal Title: Synapse Volume: 66(2) Pages: 180-186
  • Peer Reviewed
• [Journal Article] Effect of aripiprazole on anxiety associated with ethanol physical dependence and on ethanol-induced place preference. (2012)
  • Author(s): Shibasaki M, Kurokawa K, Mizuno K, Ohkuma S.
  • Journal Title: J Pharmacol Sci Volume: 118 Pages: 215-224
  • NAID: 10030454888
  • Peer Reviewed
• [Journal Article] Effects of dronabinol on morphine-induced dopamine-related behavioral effects in animals. (2012)
  • Author(s): Mori T, Shibasaki M, Abe M, Udagawa Y, Suzuki T.
  • Journal Title: Synapse Volume: 66 Issue: 11 Pages: 931-7
  • DOI: 10.1002/syn.21586
  • Peer Reviewed
• [Journal Article] Torigoe K, Mori T, Shibasaki M, Yoshizawa K, Narita M, Suzuki T (2012)
  • Author(s): Olanzapine suppresses the rewarding and discriminative stimulus effects induced by morphine.
  • Journal Title: Synapse Volume: 66 Issue: 2 Pages: 174-179
  • DOI: 10.1002/syn.21500
  • Peer Reviewed
• [Journal Article] Regulation of type 1 inositol 1,4,5-triphosphate receptor by dopamine receptors in cocaine-induced place conditioning. (2012)
  • Author(s): Kurokawa K, Mizuno K, Shibasaki M, Ohkuma S.
  • Journal Title: Synapse Volume: 66 Issue: 2 Pages: 180-186
  • DOI: 10.1002/syn.20997
  • Peer Reviewed
• [Journal Article] Up-regulation of Ca(v)1.2 subunit via facilitating trafficking induced by Vps34 on morphine-induced place preference in mice. (2011)
  • Author(s): Shibasaki M, Kurokawa K, Mizuno K, Ohkuma S
  • Journal Title: Eur J Pharmacol Volume: 651(1-3) Pages: 137-145
  • Peer Reviewed
• [Journal Article] Functional homology between alcohol dependence and mood disorder (2011)
  • Author(s): Shibasaki M, Kurokawa K, Ohkuma S.
  • Journal Title: Nihon Arukoru Yakubutsu Igakkai Zasshi Volume: 46(3) Pages: 337-346
  • NAID: 10029276474
  • Peer Reviewed
• [Journal Article] Enhancement of histoneacetylation in midbrain of mice with ethanol physical dependence and its withdrawal. (2011)
  • Author(s): Shibasaki M, Mizuno K, Kurokawa K, Ohkuma S
  • Journal Title: Synapse Volume: 65(11) Pages: 1244-1250
  • Peer Reviewed
• [Journal Article] L-type voltage-dependent calcium channels facilitate acetylation of histone H3 through PKC gamma phosphorylation in mice with methamphetamine-induced place preference. (2011)
  • Author(s): Shibasaki M, Mizuno K, Kurokawa K, Ohkuma S
  • Journal Title: J Neurochem Volume: 118(6) Pages: 1056-1066
  • Peer Reviewed
• [Journal Article] Role of actin depolymerizing factor in the development of methamphetamine-induced place preference in mice. (2011)
  • Author(s): Shibasaki M, Mizuno K, Kurokawa K, Suzuki T, Ohkuma S.
  • Journal Title: Eur J Pharmacol Volume: 671(1-3) Pages: 70-78
  • Peer Reviewed
• [Journal Article] Dopamine D1 receptor signaling system regulates ryanodine receptor expression after intermittent exposure to methamphetamine in primary cultures of midbrain and cerebral cortical neurons. (2011)
  • Author(s): Kurokawa K, Mizuno K, Kiyokage E, Shibasaki M, Toida K, Ohkuma S.
  • Journal Title: J Neurochem Volume: 118(5) Pages: 773-783
  • Peer Reviewed
• [Journal Article] Mechanism of withdrawal syndrome in alcohol dependence (2011)
  • Author(s): Shibasaki M, Mizuno K, Ohkuma S.
  • Journal Title: Nihon Arukoru Yakubutsu Igakkai Zasshi Volume: 46(5) Pages: 413-423
  • NAID: 10029806900
  • Peer Reviewed
• [Journal Article] Cocaine increases ryanodine receptors via dopamine D1 receptors. (2011)
  • Author(s): Kurokawa K, Mizuno K, Shibasaki M, Kiyokage E, Toida K, Ohkuma S.
  • Journal Title: Synapse Volume: 65(10) Pages: 1106-1112
  • Peer Reviewed
• [Journal Article] Dopamine D(1) receptors participate in cocaine-induced place preference via regulation of ryanodine receptor expression. (2011)
  • Author(s): Kurokawa K, Mizuno K, Shibasaki M, Ohkuma S.
  • Journal Title: J Pharmacol Sci Volume: 117(2) Pages: 87-97
  • Peer Reviewed
• [Journal Article] Involvement of NMDA receptors in ryanodine receptor expression in dopaminergic neurons in the ventral tegmental area of mice with intermittent methamphetamine treatment. (2011)
  • Author(s): Kurokawa K, Shibasaki M, Kiyokage E, Mizuno K, Toida K, Ohkuma S.
  • Journal Title: Synapse Volume: 65(11) Pages: 1156-1165
  • Peer Reviewed
• [Journal Article] Gabapentin blocks methamphetamine-induced sensitization and conditioned place preference via inhibition of alpha(2)/delta-1 subunits of the voltage-gated calcium channels. (2011)
  • Author(s): Kurokawa K, Shibasaki M, Mizuno K, Ohkuma S.
  • Journal Title: Neuroscience Volume: 176 Pages: 328-335
  • Peer Reviewed
• [Journal Article] beta(1)-adrenergic receptor up-regulation induced by nadolol is mediated via signal transduction pathway coupled to alpha(1)-adrenergic receptors. (2011)
  • Author(s): Mizuno K, Kurokawa K, Shibasaki M, Ohkuma S.
  • Journal Title: Brain Res Volume: 1414 Pages: 10-21
  • Peer Reviewed
• [Journal Article] Mechanism of withdrawal syndrome in alcohol dependence (2011)
  • Author(s): Shibasaki M, Mizuno K, Ohkuma S.
  • Journal Title: Nihon Arukoru Yakubutsu Igakkai Zasshi. Volume: 46 Pages: 413-423
  • NAID: 10029806900
  • Peer Reviewed
• [Journal Article] Role of actin depolymerizing factor in the development of methamphetamine-induced place preference in mice. (2011)
  • Author(s): Shibasaki M, Mizuno K, Kurokawa K, Suzuki T, Ohkuma S.
  • Journal Title: Eur J Pharmacol. Volume: 67 Pages: 70-78
  • Peer Reviewed
• [Journal Article] Dopamine D(1) receptors participate in cocaine-induced place preference via regulation of ryanodine receptor expression. (2011)
  • Author(s): Kurokawa K, Mizuno K, Shibasaki M, Ohkuma S.
  • Journal Title: J Pharmacol Sci. Volume: 117 Pages: 87-97
  • Peer Reviewed
• [Journal Article] beta1-adrenergic receptor up-regulation induced by nadolol is mediated via signal transduction pathway coupled to alpha1-adrenergic receptors. (2011)
  • Author(s): Mizuno K, Kurokawa K, Shibasaki M, Ohkuma S.
  • Journal Title: Brain Res. Volume: 1414 Pages: 10-21
  • Peer Reviewed
• [Journal Article] Functional homology between alcohol dependence and mood disorder (2011)
  • Author(s): Shibasaki M, Kurokawa K, Ohkuma S.
  • Journal Title: Nihon Arukoru Yakubutsu Igakkai Zasshi. Volume: 46 Pages: 337-346
  • NAID: 10029276474
  • Peer Reviewed
• [Journal Article] L-type voltage-dependent calcium channels facilitate acetylation of histone H3 through PKCγ phosphorylation in mice with methamphetamine-induced place preference. (2011)
  • Author(s): Shibasaki M, Mizuno K, Kurokawa K, Ohkuma S.
  • Journal Title: J Neurochem. Volume: 118 Issue: 6 Pages: 1056-1066
  • DOI: 10.1111/j.1471-4159.2011.07387.x
  • Peer Reviewed
• [Journal Article] Dopamine D1 receptor signaling system regulates ryanodine receptor expression after intermittent exposure to methamphetamine in primary cultures of midbrain and cerebral cortical neurons (2011)
  • Author(s): Kurokawa K., Mizuno K., Kiyokage E., Shibasaki M., Toida K., and Ohkuma S
  • Journal Title: Journal of Neurochemistry Volume: 118 Issue: 5 Pages: 773-783
  • DOI: 10.1111/j.1471-4159.2011.07366.x
  • Peer Reviewed
• [Journal Article] Involvement of NMDA receptors in ryanodine receptor expression in dopaminergic neurons in the ventral tegmental area of mice with intermittent methamphetamine treatment (2011)
  • Author(s): Kurokawa K., Shibasaki M., Kiyokage E., Mizuno K., Toida K., and Ohkuma S
  • Journal Title: Synapse Volume: 65 Issue: 11 Pages: 1156-1165
  • DOI: 10.1002/syn.20953
  • Peer Reviewed
• [Journal Article] Enhancement of histone acetylation in midbrain of mice with ethanol physical dependence and its withdrawal. (2011)
  • Author(s): Shibasaki M, Mizuno K, Kurokawa K, Ohkuma S.
  • Journal Title: Synapse. Volume: 65 Issue: 11 Pages: 1244-1250
  • DOI: 10.1002/syn.20947
  • Peer Reviewed
• [Journal Article] Cocaine increases ryanodine receptors via dopamine D1 receptors (2011)
  • Author(s): Kurokawa K., Mizuno K., Shibasaki M., Kiyokage E., Toida K., and Ohkuma S
  • Journal Title: Synapse Volume: 65 Issue: 10 Pages: 1106-1112
  • DOI: 10.1002/syn.20935
  • Peer Reviewed
• [Journal Article] Gabapentin blocks methamphetamine-induced sensitization and conditioned place preference via inhibition of alpha2/delta-1 subunits of the voltage-gated calcium channels. (2011)
  • Author(s): Kurokawa K, Shibasaki M, Mizuno K, Ohkuma S.
  • Journal Title: Neuroscience. Volume: 176 Pages: 328-335
  • Peer Reviewed
• [Journal Article] Up-regulation of Ca(v)1.2 subunit via facilitating trafficking induced by Vps34 on morphine-induced place preference in mice. (2011)
  • Author(s): Shibasaki M, Kurokawa K, Mizuno K, Ohkuma S.
  • Journal Title: Eur J Pharmacol. Volume: 651 Pages: 137-145
  • Peer Reviewed
• [Presentation] アルコール依存症における脳機能変化の解析 (2013)
  • Author(s): 芝崎真裕、森友久、鈴木勉
  • Organizer: 第22回神経行動薬理若手研究者の集い
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-20
• [Presentation] Zolpidemの慢性処置によるmorphine誘発報酬効果への影響 (2013)
  • Author(s): 増川太輝,芝崎真裕,森友久,石井一典,山岸ゆい,鈴木勉
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
• [Presentation] Tsutomu Suzuki: Chronic treatment of ethanol enhanced morphine-induced (2013)
  • Author(s): Kouji Andou, Masahiro Shibasaki, Tomohisa Tsuyuki, Ami Otokozawa, Tomohisa Mori
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
• [Presentation] 薬物依存の研究( 第473 報 ) :Methamphetamine 誘発自発運動促進作用に対する lipopolysaccharides の影響 (2013)
  • Author(s): 今井敏雄, 芝崎真裕, 森友久, 鈴木勉
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] Methamphetamine 誘発自発運動促進作用に対する lipopolysaccharides の影響 (2013)
  • Author(s): 今井敏雄, 芝崎真裕, 森友久, 鈴木勉
  • Organizer: 日本薬学会第 133 年会
  • Place of Presentation: 横浜
• [Presentation] Chronic treatment of ethanol enhanced morphine-induced hyperlocomotion (2013)
  • Author(s): Kouji Andou, Masahiro Shibasaki, Tomohisa Tsuyuki, Ami Otokozawa, Tomohisa Mori, Tsutomu Suzuki
  • Organizer: 第 86 回日本薬理学会年会
  • Place of Presentation: 福岡
• [Presentation] Zolpidem の慢性処置によるmorphine 誘発報酬効果への影響 (2013)
  • Author(s): 増川太輝, 芝崎真裕, 森友久, 石井一典, 山岸ゆい, 鈴木勉
  • Organizer: 第 86 回日本薬理学会年会
  • Place of Presentation: 福岡
• [Presentation] アルコール依存症における脳機能変化の解析 (2013)
  • Author(s): 芝崎真裕、森友久、鈴木勉
  • Organizer: 第２２回神経行動薬理若手研究者の集い
  • Place of Presentation: 福岡
• [Presentation] アルコール慢性処置のモルヒネ誘発報酬効果におけるGSK3 ss signalcascadeの影響 (2012)
  • Author(s): 露木智久,芝崎真裕,安藤光史,男澤杏美,森友久,鈴木勉
  • Organizer: 第127回日本薬理学会関東部会
  • Place of Presentation: 東京
  • Year and Date: 2012-10-20
• [Presentation] Influence Of Chronic Treatment Of Zolpidem On Activation Of Dopaminergic System In Nuculeus Accumbence (2012)
  • Author(s): Masukawa, D., Shibasaki, M., Mori, T., Ishii, K., Yamagishi, Y., Suzuki, T.
  • Organizer: 16th Congress of International Society for Biomedical research on Alcoholism
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-12
• [Presentation] Chronic Ethanol Treatment Alters Morphine-Induced Rewarding Effect Through Mor Receptor-Mediated Functional Changes (2012)
  • Author(s): Tsuyuki, T., Shibasaki, M., Takeda, K., Mori, T., Suzuki, T.
  • Organizer: 16th Congress of International Society for Biomedical research on Alcoholism
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-12
• [Presentation] Lipopolysaccharides (LPS)によるミクログリアの活性化がmethamphetamine誘発報酬効果に及ぼす影響 (2012)
  • Author(s): 増川太輝,芝崎真裕,秋田由花子,三竹真里子,森友久,鈴木勉
  • Organizer: 第21回神経行動薬理若手研究者の集
  • Place of Presentation: 京都
  • Year and Date: 2012-03-13
• [Presentation] アルコール慢性処置に対するモルヒネの報酬効果と鎮痛効果の影響 (2012)
  • Author(s): 露木智久,芝崎真裕,武田弘太郎,森友久,
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都
• [Presentation] Effects of chronic treatment with alcohol on the morphine-induced rewarding effects.74th Annual Meeting-College on Problems of Drug Dependence (2012)
  • Author(s): Shibasaki, M., Tsuyuki, T., Takeda, K., Mori, T., Suzuki, T.
  • Organizer: 74th Annual Meeting-College on Problems of Drug Dependence
  • Place of Presentation: Califolnia
• [Presentation] Effect of benzodiazepines on morphine-induced hyperlocomotion accompanied by the changes of KCC2 in the nucleus accumbens (2012)
  • Author(s): Masukawa, D., Shibasaki, M., Mori, T., Ishii, K., Saitoh, Y., Yamagishi, Y., Suzuki, T
  • Organizer: 74th Annual Meeting-College on Problems of Drug Dependence
  • Place of Presentation: Califolnia
• [Presentation] アルコール慢性処置のモルヒネ誘発報酬効果における GSK3β signal cascade の影響 (2012)
  • Author(s): 露木智久, 芝﨑真裕, 安藤光史, 男澤杏美, 森友久, 鈴木勉
  • Organizer: 第127 回日本薬理学会関東部会
  • Place of Presentation: 東京
• [Presentation] Chronic Ethanol Treatment Alters Morphine-Induced Rewarding Effect Through Mor Receptor- Mediated Functional Changes. (2012)
  • Author(s): Tsuyuki, T., Shibasaki, M., Takeda, K., Mori, T., Suzuki, T.
  • Organizer: 16th Congress of International Society for Biomedical research on Alcoholism
  • Place of Presentation: 札幌
• [Presentation] Influence Of Chronic Treatment Of Zolpidem On Activation Of Dopaminergic System In Nuculeus Accumbence. (2012)
  • Author(s): Masukawa, D., Shibasaki, M., Mori, T., Ishii, K., Yamagishi, Y., Suzuki, T.
  • Organizer: 16th Congress of International Society for Biomedical research on Alcoholism
  • Place of Presentation: 札幌
• [Presentation] Effect of benzodiazepines on morphine-induced hyperlocomotion accompanied by the changes of KCC2 in the nucleus accumbens. (2012)
  • Author(s): Masukawa, D., Shibasaki, M., Mori, T., Ishii, K., Saitoh, Y., Yamagishi, Y., Suzuki, T.
  • Organizer: 74th Annual Meeting-College on Problems of Drug Dependence
  • Place of Presentation: Califolnia
• [Presentation] Effects of chronic treatment with alcohol on the morphine-induced rewarding effects.74th Annual Meeting-College on Problems of Drug Dependence. (2012)
  • Author(s): Shibasaki, M., Tsuyuki, T., Takeda, K., Mori, T., Suzuki, T.
  • Organizer: 74th Annual Meeting-College on Problems of Drug Dependence
  • Place of Presentation: Califolnia
• [Presentation] Morphine 誘発報酬効果に対する cannabinoid 1 受容体作動薬の影響 (2011)
  • Author(s): 阿部美奈子,芝崎真裕,森友久,鈴木勉
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会年会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-27
• [Presentation] アルコール慢性処置によるモルヒネ誘発報酬効果の変化 (2011)
  • Author(s): 武田弘太郎,芝崎真裕,露木智久,森友久,鈴木勉
  • Organizer: アルコール精神依存関連学会合同学術総会
  • Place of Presentation: 名古屋
• [Presentation] Benzodiazepine系薬物の中脳辺縁系に及ぼす影響 (2011)
  • Author(s): 増川太輝,芝崎真裕,森友久,石井一典,斉藤祐輔,山岸ゆい,鈴木勉
  • Organizer: 第21回日本臨床精神神経薬理学会
  • Place of Presentation: 東京
• [Presentation] Methamphetamine誘発報酬効果に対するlipopolysaccharides(LPS)の影響と脳内mRNA発現変動の解析 (2011)
  • Author(s): 秋田由花子,芝崎真裕,増川太輝,森友久,鈴木勉
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会年会
  • Place of Presentation: 東京
• [Presentation] κ オピオイド受容体作動薬 U-50,488H の弁別刺激効果発現における ERK 経路の役割 (2011)
  • Author(s): 磯谷香奈，吉澤一巳，長瀬博，芝崎真裕，佐伯麻衣，成田道子，今井哲司，成田年，鈴木勉
  • Organizer: 第 124 回日本薬理学会関東部会
  • Place of Presentation: 東京
• [Presentation] アルコール慢性処置によるモルヒネの薬理作用に対する影響 (2011)
  • Author(s): 武田弘太郎，芝崎真裕，露木智久，森友久，鈴木勉
  • Organizer: 第 5 回日本緩和医療薬学会
  • Place of Presentation: 千葉
• [Presentation] オピオイド鎮痛薬による消化管輸送能抑制の作用機序解析 (2011)
  • Author(s): 長谷川実奈美，森友久，鳥越一宏，芝崎真裕，松本健次郎，堀江俊治，鈴木勉
  • Organizer: 第 5 回日本緩和医療薬学会
  • Place of Presentation: 千葉
• [Presentation] Morphine の鎮痛効果に対するカンナビノイド製剤の影響 (2011)
  • Author(s): 米山博士，芝崎真裕，春宮昌人，森友久，的場元弘，鈴木勉
  • Organizer: 第 5 回日本緩和医療薬学会
  • Place of Presentation: 千葉
• [Presentation] モルヒネ誘発嘔気・嘔吐に対する中枢性抗コリン薬の有用性の検討 (2011)
  • Author(s): 鳥越一宏，成田年，中原加恵，吉澤一巳，Mahardian Rahmadi，武田弘太郎，米山博士，堀之内藍，芝崎真裕，森友久，鈴木勉
  • Organizer: 第 5 回日本緩和医療薬学会
  • Place of Presentation: 千葉
• [Presentation] アルコール慢性処置によるモルヒネ誘発報酬効果の変化 (2011)
  • Author(s): 武田弘太郎，芝崎真裕，露木智久，森友久，鈴木勉
  • Organizer: アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 名古屋
• [Presentation] アルコール慢性処置によるモルヒネ誘発報酬効果ならびに鎮痛効果に対する影響 (2011)
  • Author(s): 武田弘太郎，芝崎真裕，露木智久，森友久，鈴木勉
  • Organizer: 第 21 回 日本臨床精神神経薬理学会・第 41 回日本神経精神薬理学会年会
  • Place of Presentation: 東京
• [Presentation] Benzodiazepine 系薬物の中脳辺縁系に及ぼす影響 (2011)
  • Author(s): 増川太輝，芝崎真裕，森友久，石井一典，斉藤祐輔，山岸ゆい，鈴木勉
  • Organizer: 第 21 回 日本臨床精神神経薬理学会・第 41 回日本神経精神薬理学会年会
  • Place of Presentation: 東京
• [Presentation] Methamphetamine 誘発報酬効果に対する lipopolysaccharides（LPS）の影響と脳内 mRNA 発現変動の解析 (2011)
  • Author(s): 秋田由花子，芝崎真裕，増川太輝，森友久，鈴木勉
  • Organizer: 第 21 回 日本臨床精神神経薬理学会・第 41 回日本神経精神薬理学会年会
  • Place of Presentation: 東京
• [Presentation] Morphine 誘発報酬効果に対する cannabinoid 1 受容体作動薬の影響 (2011)
  • Author(s): 阿部美奈子，芝崎真裕，森友久，鈴木勉
  • Organizer: 第 21 回 日本臨床精神神経薬理学会・第 41 回日本神経精神薬理学会年会
  • Place of Presentation: 東京
• [Presentation] Benzodiazepine 系薬物慢性処置による morphine 誘発自発運動促進作用への影響 (2011)
  • Author(s): 増川太輝，芝崎真裕，森友久，鈴木勉
  • Organizer: 第 125 回 日本薬理学会関東部会
  • Place of Presentation: 千葉
• [Book] 脳とこころのプライマリ・ケア 第8巻 依存 VI.薬物依存の基礎と臨床 2.ベンゾジアゼピン依存 a.ベンゾジアゼピン依存の基礎 (2011)
  • Author(s): 芝崎真裕、大熊誠太郎
  • Publisher: Synergy
• [Book] 期待される新薬 (2011)
  • Author(s): 芝崎真裕, 芝崎由美子, 鈴木 勉
  • Publisher: 医薬ジャーナル
• [Remarks]
  • URL: http://polaris.hoshi.ac.jp/kyoshitsu/dokusei/home/Top.html
• [Remarks] 星薬科大学薬品毒性学研究室
  • URL: http://polaris.hoshi.ac.jp/kyoshitsu/dokusei/home/Top.html