Metabotropic glutamate receptor regulates Schwann cell differentiation and proliferation

• Project/Area Number: 23700462
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Tokyo Women's Medical University (2012); National Center of Neurology and Psychiatry (2011)
• Principal Investigator: SAITOH Fuminori 東京女子医科大学, 医学部, 助教 (50435723)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: シュワン細胞 / 代謝型グルタミン酸受容体

Research Abstract

Glutamate promotes Schwann cells proliferation and inhibits Schwann cell myelination, but its precise mechanism has remained unclear. We found that glutamate activates Erk signaling, which is important for Schwann cell de-differentiation and proliferation. This glutamate mediated Erk activation was blocked by mGluR2/3 antagonist. Furthermore, blockade of mGluR2 signaling promotes differentiation. These results indicate that the glutamate-mGluR2 signaling may play an important role in regulating Schwann cell differentiation and proliferation.

Research Products

• [Journal Article] ZNRF1 promotes Wallerian degeneration by degrading Akt to induce GSK-3β-dependent CRMP-2 phosphorylation (2011)
  • Author(s): Shuji Wakatsuki, Fuminori Saitoh and Toshiyuki Araki.
  • Journal Title: Nature Cell Biol. Volume: 13 Issue: 12 Pages: 1415-1423
  • DOI: 10.1038/ncb2373
  • Peer Reviewed
• [Presentation] 代謝型グルタミン酸受容体を介したシュワン細胞の増殖・分化制御機構 (2012)
  • Author(s): 齋藤文典,若月修二,荒木敏之
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-12
• [Presentation] 糖化タンパク質が関与する末梢神経ミエリン化調節機構の解明と脱髄性疾患への治療応用 (2012)
  • Author(s): 萩原裕子, 齋藤文典, 若月修二, 荒木敏之
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-12
• [Presentation] Metabotropic glutamate receptor regulates Schwann celldifferentiation and proliferation (2011)
  • Author(s): 齋藤文典, 若月修二, 荒木敏之
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-13
• [Presentation] Metabotropic glutamate receptor regulates Schwann cell differentiation and proliferation. (2011)
  • Author(s): 齋藤文典・若月修二・荒木敏之
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜