• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Neural control of saccades by the fastigial nucleus

Research Project

Project/Area Number 23700466
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology and muscle physiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TAKAHASHI Mayu  東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (50581344)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords姿勢・運動制御 / 眼球運動 / 小脳 / 運動制御 / 上丘 / 脳幹 / 神経生理
Research Abstract

To understand the functional role of the oculomotor fastigial nucleus (oFN) for control of saccades, we analyzed the inputs to and the output from the oFN using electrophysiological and anatomical methods. The projection from the oFN terminated densely in the area caudal to the abducens nucleus, but scarcely in the area rostral to it. Neurons in the NRG received strong excitation from the oFN, whereas neurons in the NRPc received almost no excitation. These data suggested that neurons in the NRG that project to the cervical MN are related to motor control of gaze (eye and head). In fact, NRG neurons received strong monosynaptic excitation from the contralateral superior colliculus and disynaptic excitation from the ipsilateral one.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (35 results)

All 2014 2013 2012 2011

All Journal Article (13 results) (of which Peer Reviewed: 12 results) Presentation (21 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] Convergent synaptic inputs from the caudal fastigial nucleus and the superior colliculus onto pontine and pontomedullary reticulospinal neurons2014

    • Author(s)
      Takahashi M, Sugiuchi Y, Shinoda Y
    • Journal Title

      J Neurophysiol.

      Volume: 111 Pages: 849-867

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Convergent synaptic inputs from the caudal fastigial nucleus and the superior colliculus onto pontine and pontomedullary reticulospinal neurons.2014

    • Author(s)
      Mayu Takahashi, Yuriko Sugiuchi, and Yoshikazu Shinoda
    • Journal Title

      Journal of Neurophysiology

      Volume: 111 Issue: 4 Pages: 849-867

    • DOI

      10.1152/jn.00634.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Input-Output Organization of Inhibitory Neurons in the Interstitial Nucleus of Cajal Projecting to the Contralateral Trochlear and Oculomotor Nucleus2013

    • Author(s)
      Sugiuchi Y, Takahashi M, Shinoda Y.
    • Journal Title

      J Neurophysiol.

      Volume: 110 Pages: 640-657

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 眼球運動制御系における上丘間抑制性及び興奮性交連結合の性質について2013

    • Author(s)
      高橋真有
    • Journal Title

      Equibrium Research

      Volume: Vol.72(2) Pages: 68-77

    • NAID

      10031167653

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 眼球運動制御系における上丘間抑制性及び興奮性交連結合の性質について2013

    • Author(s)
      高橋 真有
    • Journal Title

      Equilibrium Research

      Volume: 72 Pages: 68-77

    • NAID

      10031167653

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neural substrate for suppression of omnipause neurons at the onset of saccades2011

    • Author(s)
      Shinoda Y, Sugiuchi Y, Takahashi M and Izawa Y
    • Journal Title

      Annals of New York Academy of Science

      Volume: 1233 Pages: 100-106

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Commissural Inhibition between Bilateral Superior Colliculi for Saccades and Bilateral Vestibular Nuclei for Vestibulo-Ocular Reflex (VOR)2011

    • Author(s)
      Takahashi, M., Sugiuchi, Y., Shinoda, Y.
    • Journal Title

      Annals of New York Academy of Science Suppl.

      Volume: 1233 Pages: 152-174

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Input-output organization of inhibitory burst neurons in the interstitial nucleus of Cajal2011

    • Author(s)
      Sugiuchi Y, Takahashi M. Izawa Y, Shinoda Y.
    • Journal Title

      Annals of New York Academy of Science Suppl.

      Volume: 1233 Pages: 133-151

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 急速眼球運動の神経機構-前庭系との接点-2011

    • Author(s)
      杉内友理子、高橋真有
    • Journal Title

      Equibrium Research

      Volume: Vol.70 Pages: 89-94

    • NAID

      10029512309

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Commissural Inhibition between Bilateral Superior Colliculi for Saccades and Bilateral Vestibular Nuclei for Vestibulo-Ocular Reflex (VOR).2011

    • Author(s)
      Takahashi, M., Sugiuchi, Y., Shinoda, Y.
    • Journal Title

      Annals of New York Academy of Science

      Volume: 1233 Pages: 152-174

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neural substrate for suppression of omnipause neurons at the onset of saccades.2011

    • Author(s)
      Shinoda, Y., Sugiuchi, Y., Takahashi, M., Izawa, Y.
    • Journal Title

      Annals of New York Academy of Science

      Volume: 1233 Pages: 100-106

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Input-output organization of inhibitory burst neurons in the interstitial nucleus of Cajal.2011

    • Author(s)
      Sugiuchi, Y., Takahashi, M., Izawa, Y., Shinoda, Y.
    • Journal Title

      Annals of New York Academy of Science

      Volume: 1233 Pages: 133-151

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 急速眼球運動の神経機構 ―前庭系との接点―.2011

    • Author(s)
      杉内友理子, 高橋真有.
    • Journal Title

      Equilibrium Research

      Volume: 70 Pages: 89-94

    • NAID

      10029512309

    • Related Report
      2011 Research-status Report
  • [Presentation] Neural implementation of Listing's law in the saccade system (Speaker)2014

    • Author(s)
      M. Takahashi, Y. Sugiuchi, Y. Shinoda
    • Organizer
      Society for the Neural Control of Movement, 24th Annual conference
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2013 Final Research Report
  • [Presentation] Tectal commissural connections and their functional roles in saccades in relation to the VOR and Listing's law2014

    • Author(s)
      M. Takahashi, Y. Sugiuchi, Y. Shinoda
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島(口演発表(英語))
    • Related Report
      2013 Final Research Report
  • [Presentation] Tectal commissural connections and their functional roles in saccades in relation to the VOR and Listing’s law.2014

    • Author(s)
      M. Takahashi, Y. Sugiuchi, and Y. Shinoda
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neural implementation of Listing’s law in the saccade system2014

    • Author(s)
      M. Takahashi, Y. Sugiuchi, and Y. Shinoda
    • Organizer
      Society for the Neural Control of Movement, 24th Annual conference
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2013 Annual Research Report
  • [Presentation] 左右上丘間の抑制・興奮交連結合とサッケード座標系2013

    • Author(s)
      高橋真有、杉内友理子、篠田義一
    • Organizer
      第51回日本神経眼科学会
    • Place of Presentation
      秋田(口演発表)
    • Year and Date
      2013-11-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Listingの法則の中枢性神経基盤-左右上丘間の興奮性交連性結合2013

    • Author(s)
      高橋真有、杉内友理子、篠田義一
    • Organizer
      第72回日本めまい平衡医学会総会
    • Place of Presentation
      大阪(口演発表)
    • Year and Date
      2013-11-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Properties and significant roles of commissural connections between the superior colliculi for vertical saccades in relation to the vestibuloocular system and Listing's Law (Invited Speaker)2013

    • Author(s)
      Mayu Takahashi
    • Organizer
      As an invited speaker in the symposium in honor of Prof. Hall. Gordon Research Conference on "Eye Movements"
    • Place of Presentation
      Stonehill College, Easton, MA, USA
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Properties and significant roles of commissural connections between the superior colliculi for vertical saccades in relation to the vestibuloocular system and Listing's Law.2013

    • Author(s)
      Mayu Takahashi
    • Organizer
      Gordon Research Conference on “Eye Movements”
    • Place of Presentation
      Easton, MA, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Listingの法則の中枢性神経基盤-左右上丘間の興奮性交連性結合2013

    • Author(s)
      高橋真有、杉内友理子、篠田義一
    • Organizer
      第72回日本めまい平衡医学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 左右上丘間の抑制・興奮交連結合とサッケード座標系2013

    • Author(s)
      高橋真有、杉内友理子、篠田義一
    • Organizer
      第51回日本神経眼科学会
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
  • [Presentation] Properties and significant roles of commissural connections between the superior colliculi for vertical saccades in relation to the vestibuloocular system and Listing's law.2013

    • Author(s)
      Mayu Takahashi
    • Organizer
      Gordon Research Conference on "Eye Movements"
    • Place of Presentation
      Stonehill College, Easton, MA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Functional roles of commissural inhibition and excitation between the superior colliculi for control of saccades in relation to Listing's law and the VOR (Speaker)2012

    • Author(s)
      M. Takahashi, Y. Sugiuchi, Y. Shinoda
    • Organizer
      Society for the Neural Control of Movement, 22nd Annual conference
    • Place of Presentation
      Venice, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional roles of commissural inhibition and excitation between the superior colliculi for control of vertical saccades in relation to the VOR and Listing's law2012

    • Author(s)
      M. Takahashi, Y. Sugiuchi, Y. Shinoda
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋(口演発表(英語))
    • Related Report
      2013 Final Research Report
  • [Presentation] サッケード系の座標軸とListingの法則の中枢性神経基盤2012

    • Author(s)
      高橋真有、杉内友理子、篠田義一
    • Organizer
      第71回日本めまい平衡医学会総会
    • Place of Presentation
      東京(口演発表)
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional roles of commissural inhibition and excitation between the superior colliculi for control of saccades in relation to Listing's law and the VOR.2012

    • Author(s)
      Takahashi, M., Sugiuchi, Y., Shinoda, Y.
    • Organizer
      Society for the Neural Control of Movement, 22nd Annual conference
    • Place of Presentation
      Venice, Italy
    • Related Report
      2012 Research-status Report
  • [Presentation] Functional roles of commissural inhibition and excitation between the superior colliculi for control of vertical saccades in relation to the VOR and Listing’s law.2012

    • Author(s)
      Takahashi, M., Sugiuchi, Y., Shinoda, Y.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] サッケード系の座標軸とListingの法則の中枢性神経基盤2012

    • Author(s)
      高橋真有、杉内友理子、篠田義一
    • Organizer
      第71回日本めまい平衡医学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Functional roles of tectal commissural inhibition and excitation for generation of horizontal and vertical saccades (Poster presentation)2011

    • Author(s)
      Takahashi M, Sugiuchi Y, and Shinoda Y
    • Organizer
      Gordon Research Conference on Eye Movements - The Motor System that Sees the World-
    • Place of Presentation
      Biddeford, ME, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 垂直性サッケード生成における上丘交連性結合の機能的役割と前庭眼球運動(VOR)系との相似2011

    • Author(s)
      高橋真有、杉内友理子、篠田義一
    • Organizer
      第70回日本めまい平衡医学会総会
    • Place of Presentation
      千葉(口演発表)
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional roles of tectal commissural inhibition and excitation for generation of horizontal and vertical saccades.2011

    • Author(s)
      Takahashi, M., Sugiuchi, Y., Shinoda, Y.
    • Organizer
      Gordon Research Cnference on "Eye Movements"
    • Place of Presentation
      University of New England, Biddeford, Maine, U.S.A.
    • Related Report
      2011 Research-status Report
  • [Presentation] 垂直性サッケード生成における上丘交連性結合の機能的役割と前庭眼球運動(VOR)系との相似.2011

    • Author(s)
      高橋真有, 杉内友理子, 篠田義一.
    • Organizer
      第70回日本めまい平衡医学会総会
    • Place of Presentation
      幕張(千葉)
    • Related Report
      2011 Research-status Report
  • [Book] 聴覚性脳幹誘発電位Auditory braintem evoked potantial、『新訂・生理学実習書』、日本生理学会教育委員会監修2013

    • Author(s)
      高橋真有、 杉原泉
    • Publisher
      南江堂
    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi