Analysis of gene expression program governing the transition from axon growth phase to synaptogenic phase

• Project/Area Number: 23700472
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Keio University
• Principal Investigator: KUWAKO Ken-ichiro 慶應義塾大学, 医学部, 特任助教 (30468475)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 軸索伸展 / シナプス形成 / 遺伝子発現 / 神経回路 / 国際情報交流

Research Abstract

In the developing pontine neurons (PN), we identified transcription factors that were up/down-regulated in the presence of cerebellar granule cells which are target cells of PN axons. Among those transcription factors, multiple molecules showed the abilit

Research Products

• [Journal Article] Sox21 promotes hippocampal adult neurogenesis via the transcriptional repression of the Hes5 gene. (2012)
  • Author(s): Matsuda Satoru, Kuwako Ken-ichiro et al.
  • Journal Title: Journal of Neuroscience Volume: 32 Issue: 36 Pages: 12543-12557
  • DOI: 10.1523/jneurosci.5803-11.2012
  • Peer Reviewed
• [Presentation] Analysis of mechanism regulating synaptic specificity in cerebellar limbic system (2012)
  • Author(s): 桑子賢一郎、岡野栄之
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡国際会議場・ マリンメッセ福岡
  • Year and Date: 2012-12-14
• [Presentation] 小脳辺縁系神経回路の特異的シナプ ス結合を制御する分子の探索 (2012)
  • Author(s): 桑子賢一郎、岡野栄之
  • Organizer: 第35回日本神経科学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2012-09-21
• [Presentation] Screening for molecules regulating synaptic specificity in cerebellar limbic system (2012)
  • Author(s): Ken-ichiro Kuwako, Hideyuki Okano
  • Organizer: The 4th Biennial Symposium on Brain and Mind Research in the Asia-Pacific (BMAP 2012)
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2012-08-30
• [Presentation] 特異的神経回路形成を担う遺伝子発現プログラムの解析 (2011)
  • Author(s): 桑子賢一郎、岡野栄之
  • Organizer: 第34回日本神経科学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-09-17
• [Presentation] 特異的神経回路形成を担う遺伝子発現プログラムの解析 (2011)
  • Author(s): 桑子賢一郎、岡野栄之
  • Organizer: 第３４回日本神経科学会
  • Place of Presentation: パシフィコ横浜（ 神奈川県）
• [Presentation] 小脳辺縁系神経回路のシナプス接続を制御する分子機構の解析
  • Author(s): 桑子賢一郎、岡野栄之
  • Organizer: 第３６回日本神経科学会
  • Place of Presentation: 国立京都国際会館
• [Presentation] Analysis of mechanism regulating synaptic specificity in cerebellar limbic system
  • Author(s): 桑子賢一郎、岡野栄之
  • Organizer: 第３５回日本分子生物学会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡
• [Presentation] 小脳辺縁系神経回路の特異的シナプス結合を制御する分子の探索
  • Author(s): 桑子賢一郎、岡野栄之
  • Organizer: 第３５回日本神経科学会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Screening for molecules regulating synaptic specificity in cerebellar limbic system
  • Author(s): Ken-ichiro Kuwako, Hideyuki Okano
  • Organizer: The 4th Biennial Symposium on Brain and Mind Research in
 the Asia-Pacific
  • Place of Presentation: 慶應義塾大学
• [Book] 神経回路形成をつかさどる遺伝子発現プログラム (2013)
  • Author(s): 桑子賢一郎 ほか 8 名
  • Publisher: (株)クバプロ
• [Book] ブレインサイエンスレビュー２０１３ (2013)
  • Author(s): 廣川信隆（編集）、桑子賢一郎ほか（著）
  • Total Pages: 186
  • Publisher: クバプロ