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Mechanism of the basal ganglia circuit to regulate motor and motor learning Mechanism of the basal ganglia circuit to regulate motor and motor learning

Research Project

Project/Area Number 23700479
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology and muscle physiology
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

SANO Hiromi  生理学研究所, 統合生理研究系, 特任助教 (00363755)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords運動 / 大脳基底核 / 大脳皮質 / 線条体 / 光遺伝学
Research Abstract

The basal ganglia is supposed to important for motor control. We have applied ‘ optogenetics (the combination of genetics and optics to control cellular excitability)’ to mice to clarify the mechanism of motor control in the pathway of the basal ganglia. Specific excitation in striatal projection neurons in the hemisphere has induced phasic inhibition in the output signal from the basal ganglia, and has induced rotational behavior. These data suggest that phasic response in the output signal is important to regulate motor activity.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (17 results) (of which Invited: 2 results) Remarks (4 results)

  • [Journal Article] Signals through the striatopallidal indirect pathway stop movements by phasic excitation in the substantia nigra.2013

    • Author(s)
      Sano et al.
    • Journal Title

      J. Neurosci.

      Volume: 33 Issue: 17 Pages: 7583-7594

    • DOI

      10.1523/jneurosci.4932-12.2013

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of optogenetically activated striatal medium spiny neurons by Npas4 expression2012

    • Author(s)
      Bepari AK, Sano H, Tamamaki N, Nambu A, Tanaka KF, Takebayashi H
    • Journal Title

      PLoS ONE

      Volume: 7(12) Issue: 12 Pages: 140-140

    • DOI

      10.1371/journal.pone.0052783

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system2012

    • Author(s)
      K. Tanaka, K. Matsui, T. Sasaki. H. Sano, S. Sugio, K. Fan, K. Ikenaka, R. Hen, J. Nakai, Y. Yanagawa, H. Hasuwa, K. Deisseroth, A. Yamanaka
    • Journal Title

      Cell Reports

      Volume: 2 Issue: 2 Pages: 397-406

    • DOI

      10.1016/j.celrep.2012.06.011

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Physiological roles of striatal projection neurons in voluntary movements.2013

    • Author(s)
      Sano Hiromi
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Striatopallidal neurons attenuate motor activity through the phasic response pattern in the basal ganglia2012

    • Author(s)
      Sano H, Chiken S, Kobayashi K, Nambu A
    • Organizer
      NEUROSCIENCE 2012
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Year and Date
      2012-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Young Investigator Colloquia: Neurodegeneration Pathophysiology and therapy for basal ganglia disease2012

    • Author(s)
      Sano H, Chiken S, Murata M, Kobayashi K, Nambu A
    • Organizer
      The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry (APSN2012), The 55th Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2012-10-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Selective activation of cortico-striatal projections by using optogenetics with retrograde gene transfer2012

    • Author(s)
      Sano H, Kato S, Chiken S, Kobayashi K, Kobayashi K, Nambu A
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 光遺伝学を応用した大脳皮質-線条体経路の神経生理機能の解明2012

    • Author(s)
      佐野裕美、加藤成樹、知見聡美、小林憲 太、小林和人、南部篤
    • Organizer
      包括型脳科学研究推進支援ネットワーク夏のワークショップ
    • Place of Presentation
      仙台市
    • Year and Date
      2012-07-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Striatopallidal neurons regulate motor activity through cortically evoked response patterns in the substantia nigra pars reticulata2012

    • Author(s)
      Sano H, Chiken S, Hikida T, Kobayashi K, Nambu A
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本市
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] Striatopallidal neurons attenuate motor activity through the phasic response pattern in the basal ganglia.2012

    • Author(s)
      Sano Hiromi
    • Organizer
      NEUROSCIENCE 2012
    • Place of Presentation
      The Ernest N. Morial Convention Center (New Orleans, USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Pathophysiology and therapy for basal ganglia disease.2012

    • Author(s)
      Sano Hiromi
    • Organizer
      The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry (APSN2012), The 55th Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Selective activation of cortico-striatal projections by using optogenetics with retrograde gene transfer.2012

    • Author(s)
      Sano Hiromi
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 光遺伝学を応用した大脳皮質-線条体経路の神経生理機能の解明2012

    • Author(s)
      佐野裕美
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      仙台国際センター(仙台市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 線条体-淡蒼球投射ニューロンが制御する運動調節機構の解明2012

    • Author(s)
      佐野裕美、知見聡美、疋田貴俊、小林和人、南部篤
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館( 長野県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 線条体?淡蒼球投射ニューロンが制御する運動調節機能の解明2011

    • Author(s)
      佐野裕美、知見聡美、小林和人、南部篤
    • Organizer
      第58回中部日本生理学会
    • Place of Presentation
      福井市
    • Year and Date
      2011-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Striatopallidal neurons regulate motor activity through response pattern in the external segment of globus pallidus and substantia nigra pars reticulata2011

    • Author(s)
      Sano H, Chiken S, Kobayashi K, Nambu A
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 大脳基底核の生理機能解明への光遺伝学の応用2011

    • Author(s)
      佐野裕美、加藤成樹、知見聡美、小林憲太、小林和人、南部篤
    • Organizer
      包括型脳科学研究推進支援ネットワーク夏のワークショップ
    • Place of Presentation
      神戸市
    • Year and Date
      2011-08-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 大脳基底核の生理機能の解明への光遺伝学の応用2011

    • Author(s)
      佐野裕美、知見聡美、加藤成樹、小林憲太、小林和人、南部篤
    • Organizer
      包括型脳科学研究推進支援ネットワーク夏のワークショップ
    • Place of Presentation
      神戸国際会議場( 兵庫県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 線条体-淡蒼球投射ニューロンは淡蒼球外節および黒質網様部の応答パターンを介して運動を制御する2011

    • Author(s)
      佐野裕美、知見聡美、小林和人、南部篤
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜( 神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 線条体-淡蒼球投射ニューロンが制御する運動調節機構の解明2011

    • Author(s)
      佐野裕美、知見聡美、小林和人、南部篤
    • Organizer
      第58回中部日本生理学会
    • Place of Presentation
      県民ホール( 福井県)
    • Related Report
      2011 Research-status Report
  • [Remarks] 生理学研究所ホームページ、プレスリリース

    • Related Report
      2012 Final Research Report
  • [Remarks] 日本神経科学学会ホームページ、神経科学トピックス

    • URL

      http://www.jnss.org/20130524-02/

    • Related Report
      2012 Final Research Report
  • [Remarks] 日本生理学会ホームページ、サイエンストピックス

    • URL

      http://physiology.jp/exec/page/stopics85/

    • Related Report
      2012 Final Research Report
  • [Remarks] 日経産業新聞、2013年4月25日、11面、意思に反した手足の動きを抑える神経回路発見

    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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