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Comparison of cortical and spinal contributions to the control of primate hand movements

Research Project

Project/Area Number 23700482
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology and muscle physiology
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

TAKEI Tomohiko  独立行政法人国立精神・神経医療研究センター, 神経研究所モデル動物開発研究部, 客員研究員 (50527950)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords把握運動 / 脊髄 / 大脳皮質一次運動野 / 筋シナジー / 巧緻性 / 運動制御 / 一次運動野 / 霊長類
Outline of Final Research Achievements

Grasping is a highly complex movement, which involves a large number of hand and arm muscles. Here we explored how the spinal premotor interneurons (PreM-INs) in primate cervical cord and corticomotoneuronal cells (CM cells) in primary motor cortex are involved in coordination of the hand muscles. Our results suggested that the PreM-INs had divergent output effects on hand muscles to form the muscle synergies, which are coordinated patterns muscle activities. On the other hand, the CM cells had a fewer output effects on hand muscles to control each muscle in a more independent manner. These results suggested that primate hand movements are controlled by the two parallel pathways, which are dedicated to synergistic and relatively independent controls. This parallel control might be important to achieve the effective and flexible controls of complex hand movement.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (11 results) (of which Invited: 1 results)

  • [Journal Article] Spinal premotor interneurons mediate dynamic and static motor commands for precision grip in monkeys2013

    • Author(s)
      Takei T, Seki K
    • Journal Title

      J Neurosci

      Volume: Vol. 33 Issue: 20 Pages: 8850-60

    • DOI

      10.1523/jneurosci.4032-12.2013

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synaptic and functional linkages between spinal premotor interneurons and hand- muscle activity during precision grip2013

    • Author(s)
      Takei T, Seki K
    • Journal Title

      Front Comput Neurosci

      Volume: Vol.7, No.40 Pages: 40-40

    • DOI

      10.3389/fncom.2013.00040

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Contrasting roles of spinal and cortical premotor neurons for control of grasping2014

    • Author(s)
      Takei T, Oya T, Seki K
    • Organizer
      44th annual meeting of society for neuroscience
    • Place of Presentation
      Washington DC, Walter E. Washington Convention Center
    • Related Report
      2013 Research-status Report
  • [Presentation] 把握運動制御における大脳皮質および脊髄神経機構の機能的差異2013

    • Author(s)
      武井智彦、関和彦
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      国立京都国際会館イベントホール
    • Related Report
      2013 Research-status Report
  • [Presentation] 把握運動の制御における大脳皮質よび脊髄神経機構能的差異2013

    • Author(s)
      武井智彦
    • Organizer
      第7回MotorControl研究会
    • Place of Presentation
      東京大学農部 弥生講堂 ・アネックス
    • Related Report
      2013 Research-status Report
  • [Presentation] Contribution of spinal interneurons to the control of hand grasping2012

    • Author(s)
      武井智彦,関和彦
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 10. Spinomuscular and corticomuscular coherence in monkeys performing a precision grip task.2012

    • Author(s)
      武井智彦,関和彦
    • Organizer
      第1回神経オシレーションカンファレンス
    • Place of Presentation
      岡崎コンファレンスセンター
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 把握運動は複数のフィードバックループによって制御されている2012

    • Author(s)
      武井智彦,関和彦
    • Organizer
      第6回MotorControl研究会
    • Place of Presentation
      岡崎コンファレンスセンター
    • Related Report
      2012 Research-status Report
  • [Presentation] A neural basis for hand msucle synergy in primate spinal cord2012

    • Author(s)
      Takei T., Seki K.
    • Organizer
      22nd Annual meeting of the Neural control of Movement
    • Place of Presentation
      Hilton Molino Stucky, Italy
    • Related Report
      2012 Research-status Report
  • [Presentation] 把握運動の筋シナジー形成における脊髄介在ニューロンの役割2011

    • Author(s)
      武井 智彦、関和彦
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2011 Research-status Report
  • [Presentation] Neural basis for hand muscle synergy in primate spinal cord2011

    • Author(s)
      Takei Tomohiko, Seki Kazuhiko
    • Organizer
      5th for Neuroscience Satellite Symposium on Motor Systems
    • Place of Presentation
      the Natcher Conference center, Bethesda, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Neural basis for hand muscle synergy in primate spinal cord2011

    • Author(s)
      Takei Tomohiko, Seki Kazuhiko
    • Organizer
      The 41st annual meeting of the Society for the Neuroscience
    • Place of Presentation
      Walter E. Washington Convention Center, Washington D.C., USA
    • Related Report
      2011 Research-status Report
  • [Presentation] 把握運動の筋シナジー形成に関わる脊髄介在ニューロン活動2011

    • Author(s)
      武井 智彦、関和彦
    • Organizer
      第5回MC研究会
    • Place of Presentation
      岡崎カンファレンスセンター(愛知)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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