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Development of Novel rehabilitative intervention using Neurofeedback technique

Research Project

Project/Area Number 23700500
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Fusional brain recording science
Research InstitutionOsaka University (2012)
Morinomiya Hospital Neurorehabilitation Research Institute (2011)

Principal Investigator

MIHARA Masahito  大阪大学, 大学院・医学系研究科, 特任助教 (80513150)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords脳機能操作 / ニューロフィードバック / リハビリテーション / ブレインマシンインターフェース / 脳卒中 / 運動想像 / 神経変性疾患 / 立位歩行障害
Research Abstract

We developed a neurofeedback system using real-time Near Infrared Spectroscopy (NIRS). Using this system, we evaluated whether NIRS-mediated neurofeedback combined with intensive rehabilitation therapy could augment the functional recovery after stroke. Our findings revealed that the NIRS-mediated neurofeedback can enhance the target cortical activity and augment the recovery of hand motor function. These findings proved the safety of the NIRS-mediated neurofeedback and also suggested its usefulness as the novel rehabilitative intervention.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (50 results)

All 2013 2012 2011 Other

All Journal Article (22 results) (of which Peer Reviewed: 6 results) Presentation (23 results) (of which Invited: 1 results) Book (5 results)

  • [Journal Article] Cortical changes underlying 図 2:リアルタイム解析と Offline 解析との比較図 3: 左運動野を用いたニューロフィードバックに伴い活動の変化する脳領域図 4:ニューロフィードバックによる麻痺側上肢機能改善に対する効果図 5: ニューロフィードバックに伴う脳活動変化と機能改善との相関 balance recovery in patients with hemiplegic stroke.2013

    • Author(s)
      Fujimoto H, Mihara M, Hattori N, Hatakenaka M, Kawano T, Yagura H, Miyai I, Mochizuki H
    • Journal Title

      Neuroimage

      Volume: (in press)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Near-infrared Spectroscopy-mediated Neurofeedback Enhances Efficacy of Motor Imagery-based Training in Poststroke Victims: A Pilot Study2013

    • Author(s)
      Mihara M, Hattori N, Hatakenaka M, Yagura H, Kawano T, Hino T, Miyai I.
    • Journal Title

      Stroke

      Volume: 44(4) Pages: 1091-8

    • Related Report
      2012 Final Research Report
  • [Journal Article] Near-infrared Spectroscopy-mediated Neurofeedback Enhances Efficacy of Motor Imagery-based Training in Poststroke Victims: A Pilot Study.2013

    • Author(s)
      Masahito Mihara
    • Journal Title

      Stroke

      Volume: 44 Issue: 4 Pages: 1091-1098

    • DOI

      10.1161/strokeaha.111.674507

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cortical changes underlying balance recovery in patients with hemiplegic stroke2013

    • Author(s)
      Hiroaki Fujimoto
    • Journal Title

      NeuroImage

      Volume: 000 Pages: 0-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurofeedback using real-time near-infrared spectroscopy enhances motor imagery related cortical activation2012

    • Author(s)
      Mihara M, Miyai I, Hattori N, Hatakenaka M, Yagura H, Kawano T, Okibayashi M, Danjo N, Ishikawa A, Inoue Y, Kubota K
    • Journal Title

      PLoS One.

      Volume: 7(3)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Cortical control of postural balance in patients with hemiplegic stroke.2012

    • Author(s)
      Mihara M, Miyai I, Hattori N, Hatakenaka M, Yagura H, Kawano T, Kubota K.
    • Journal Title

      Neuroreport.

      Volume: 23(5) Pages: 314-9

    • Related Report
      2012 Final Research Report
  • [Journal Article] Cerebellar Ataxia Rehabilitation Trialists Collaboration. Cerebellar ataxia rehabilitation trial in degenerative cerebellar diseases.2012

    • Author(s)
      Miyai I, Ito M, Hattori N, Mihara M, Hatakenaka M, Yagura H, Sobue G, Nishizawa M
    • Journal Title

      Neurorehabil Neural Repair.

      Volume: 26(5) Pages: 515-22

    • Related Report
      2012 Final Research Report
  • [Journal Article] Impaired motor learning by a pursuit rotor test reduces functional outcomes during rehabilitation of poststroke ataxia.2012

    • Author(s)
      Hatakenaka M, Miyai I, Mihara M, Yagura H, Hattori N.
    • Journal Title

      Neurorehabil Neural Repair

      Volume: 26(3) Pages: 293-300

    • Related Report
      2012 Final Research Report
  • [Journal Article] Neurofeedback Using Real-Time Near-Infrared Spectroscopy Enhances Motor Imagery Related Cortical Activation2012

    • Author(s)
      Masahito Mihara
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 3 Pages: e32234-e32234

    • DOI

      10.1371/journal.pone.0032234

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cortical control of postural balance in patients with hemiplegic stroke.2012

    • Author(s)
      Masahito Mihara
    • Journal Title

      NeuroReport

      Volume: 23 Issue: 5 Pages: 314-319

    • DOI

      10.1097/wnr.0b013e328351757b

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cerebellar ataxia rehabilitation trial in degenerative cerebellar diseases.2012

    • Author(s)
      Miyai Ichiro
    • Journal Title

      Neurorehabilitation and Neural Repair

      Volume: 26 Issue: 5 Pages: 512-522

    • DOI

      10.1177/1545968311425918

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired motor learning by a pursuit rotor test reduces functional outcomes during rehabilitation of poststroke ataxia.2012

    • Author(s)
      Megumi Hatakenaka
    • Journal Title

      Neurorehabil Neural Repair.

      Volume: 26 Issue: 3 Pages: 293-300

    • DOI

      10.1177/1545968311412053

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain-machine interfaceはどこまで可能か? Real-time NIRSによるニューロフィードバックをもちいた神経リハビリテーション2012

    • Author(s)
      三原雅史
    • Journal Title

      臨床神経学

      Volume: 51 Pages: 924-926

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 【ニューロリハの最前線】 Real-time NIRSによるニューロフィードバックを用いたニューロリハ2012

    • Author(s)
      三原雅史
    • Journal Title

      分子脳血管病

      Volume: 11 Pages: 271-277

    • Related Report
      2012 Annual Research Report
  • [Journal Article] パーキンソン病の最新リハビリテーション2012

    • Author(s)
      三原雅史
    • Journal Title

      Journal of Clinical Rehabilitation

      Volume: 21 Pages: 1086-1090

    • Related Report
      2012 Annual Research Report
  • [Journal Article] リハビリテーションからみた神経回路の可塑性と BMI 脳機能解析と神経リハビリテーション

    • Author(s)
      宮井 一郎, 三原 雅史, 服部 憲明, 畠中めぐみ, 河野 悌司, 矢倉 一
    • Journal Title

      臨床神経学(0009-918X)

      Volume: 52巻 11 号 Pages: 1174-1177

    • Related Report
      2012 Final Research Report
  • [Journal Article] パーキンソン病の最新リハビリテーション

    • Author(s)
      三原 雅史, 望月 秀樹
    • Journal Title

      Journal of Clinical Rehabilitation(0918-5259)

      Volume: 21巻11 号 Pages: 1086-1090

    • Related Report
      2012 Final Research Report
  • [Journal Article] Real-time NIRS によるニューロフィードバックを用いたニューロリハ分子

    • Author(s)
      三原 雅史
    • Journal Title

      脳血管病(1346-8995)

      Volume: 11巻 3 号 Pages: 271-277

    • Related Report
      2012 Final Research Report
  • [Journal Article] Brain-machine interface はどこまで可能か? Real-time NIRS によるニューロフィードバックをもちいた神経リハビリテーション

    • Author(s)
      三原 雅史
    • Journal Title

      臨床神経学(0009-918X)

      Volume: 51巻11 号 Pages: 924-926

    • Related Report
      2012 Final Research Report
  • [Journal Article] SCD の治療 脊髄小脳変性症のリハビリテーション

    • Author(s)
      畠中 めぐみ, 服部 憲明, 三原 雅史, 宮井 一郎
    • Journal Title

      最新医学(0370-8241)

      Volume: 67巻 5 号 Pages: 1155-1161

    • Related Report
      2012 Final Research Report
  • [Journal Article] 神経変性疾患のリハビリテーション

    • Author(s)
      畠中 めぐみ, 三原 雅史, 服部 憲明, 宮井 一郎
    • Journal Title

      医薬ジャーナル(0287-4741)

      Volume: 48巻 5 号 Pages: 1331-1335

    • Related Report
      2012 Final Research Report
  • [Journal Article] 神経リハビリテーション

    • Author(s)
      河野 悌司, 畠中 めぐみ, 三原 雅史, 服部 憲明, 日野 太郎, 矢倉 一, 宮井 一郎
    • Journal Title

      総合リハビリテーション(0386-9822)

      Volume: 39巻 12 号 Pages: 1151-1156

    • Related Report
      2012 Final Research Report
  • [Presentation] シンポジウム「神経機能再建:ニューロリハビリテーションの最前線」NIRS によるニューロフィードバックを用いたニューロリハビリテーション2013

    • Author(s)
      三原雅史
    • Organizer
      第38回日本脳卒中学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳卒中後の片麻痺患者における立位姿勢バランス能力改善と大脳皮質活動との関連性2013

    • Author(s)
      藤本宏明、三原雅史、畠中めぐみ、服部憲明、矢倉一、吉岡知美、河野悌司、望月秀樹、宮井一郎
    • Organizer
      第11回 姿勢と歩行研究会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional near-infrared spectroscopy as an evaluation and possible training tool for postural control and balance2013

    • Author(s)
      Masahito Mihara
    • Organizer
      35th Annual International IEEE EMBS Conference
    • Place of Presentation
      Osaka
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functional near-infrared spectroscopy as an evaluation and possible training tool for postural control and balance2013

    • Author(s)
      Masahito Mihara
    • Organizer
      the second Joint World Congress of ISPGR and Gait & Mental Function
    • Place of Presentation
      Akita
    • Related Report
      2012 Annual Research Report
  • [Presentation] NIRSによるニューロフィードバックを用いたニューロリハビリテーション2013

    • Author(s)
      三原雅史
    • Organizer
      第38回日本脳卒中学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 立位歩行能力改善のための Neurofeedback 装置の開発を目指して~小脳変性症患者への短期集中リハに伴う立位関連脳活動の変化を中心に~ 厚生労働省難治性疾患克服研究事業2012

    • Author(s)
      三原雅史,宮井一郎
    • Organizer
      希少性難治性疾患患者に関する医療の向上及び患者支援のあり方に関する研究班班会議
    • Place of Presentation
      東京
    • Year and Date
      2012-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Motor imagery-based training with NIRS-mediated neurofeedback enhances post stroke recovery2012

    • Author(s)
      Mihara M, Hattori N, Hatakenaka M, Yagura H, Kawano T, Miyai I.
    • Organizer
      BMI Osaka 2012
    • Place of Presentation
      大阪
    • Year and Date
      2012-10-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Neurorehabilitative intervention with neurofeedback system using functional near-infrared spectroscopy. Shimadzu corp.2012

    • Author(s)
      Mihara M
    • Organizer
      fNIRS seminar.
    • Place of Presentation
      Beijing, China
    • Year and Date
      2012-06-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Neurofeedback Enhance The Efficacy Of Mental Practice With Motor Imagery In Post-acute Stroke Victims: A Pilot Study.2012

    • Author(s)
      Mihara M, Hattori N, Hatakenaka M, Yagura H, Kawano T, Hino T, Miyai I.
    • Organizer
      AHA International Stroke Conference2012
    • Place of Presentation
      NewOrleans, LA
    • Year and Date
      2012-02-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Cortical mechanisms underlying balance recovery in patients with hemiplegic stroke.2012

    • Author(s)
      Fujimoto H, Mihara M, Hattori N, Hattakenaka M, Yagura H, Miyai I.
    • Organizer
      42nd Annual meeting of Society for Neuroscience
    • Place of Presentation
      New Orleans, LA
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] NIRS を用いたニューロフィードバックによる脳卒中後片麻痺に対する運動想像訓練効果の検討2012

    • Author(s)
      三原雅史、服部憲明、畠中めぐみ、矢倉一、河野悌司、日野太郎、宮井一郎
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Motor imagery-based training with NIRS-mediated neurofeedback enhances post stroke recovery2012

    • Author(s)
      Masahito Mihara
    • Organizer
      BMI Osaka 2012:国際BMIシンポジウム ブレイン・マシン・インターフェースの臨床応用
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] NIRSを用いたニューロフィードバックによる脳卒中後片麻痺に対する運動想像訓練効果の検討.2012

    • Author(s)
      三原雅史
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neurofeedback Enhance The Efficacy Of Mental Practice With Motor Imagery In Post-acute Stroke Victims: A Pilot Study.2012

    • Author(s)
      Mihara M, Hattori N, Hatakenaka M, Yagura H, Kawano T, Hino T, Miyai I.
    • Organizer
      AHA International Stroke Conference2012.
    • Place of Presentation
      NewOrleans, LA
    • Related Report
      2011 Research-status Report
  • [Presentation] 立位歩行能力改善のための Neurofeedback 装置の開発を目指して ~立位歩行バランスの評価としての脳機能測定の有用性の検証~2011

    • Author(s)
      三原雅史,宮井一郎
    • Organizer
      厚生労働省難治性疾患克服研究事業.希少性難治性疾患患者に関する医療の向上及び患者支援のあり方に関する研究班班会議.
    • Place of Presentation
      東京
    • Year and Date
      2011-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Neurofeedback using real-time near-infrared spectroscopy enhances motor imagery and related cortical activation2011

    • Author(s)
      Mihara M, Miyai I, Hattori N, Hatakenaka M, Yagura H, Kawano T, Ishikawa A,Inoue Y, Kubota K
    • Organizer
      41st Annual Meeting of Society for Neuroscience.
    • Place of Presentation
      Washington DC
    • Year and Date
      2011-11-13
    • Related Report
      2012 Final Research Report
  • [Presentation] real-time NIRS を用いた神経リハビリテーションの可能性2011

    • Author(s)
      三原雅史
    • Organizer
      第2回NU-Brain シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 近赤外分光法(NIRS)を用いたニューロフィードバックによる運動想像時の脳活動変化2011

    • Author(s)
      三原雅史,服部憲明,宮井一郎.
    • Organizer
      第5回Motor Control 研究会
    • Place of Presentation
      愛知.
    • Year and Date
      2011-06-17
    • Related Report
      2012 Final Research Report
  • [Presentation] シンポジウム:Brain-machine interface はどこまで可能か?「Real-timeNIRS によるニューロフィードバックを用いた神経リハビリテーション」2011

    • Author(s)
      三原雅史
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      愛知
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳卒中後のバランス能力回復に関与する大脳皮質領域の検討.2011

    • Author(s)
      三原雅史,服部憲明,畠中めぐみ,矢倉一,河野悌司,宮井一郎,久保田競
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      愛知
    • Related Report
      2012 Final Research Report
  • [Presentation] Neurofeedback using real-time near-infrared spectroscopy enhances motor imagery and related cortical activation.2011

    • Author(s)
      Mihara M,Miyai I,Hattori N, Hatakenaka M,Yagura H,Kawano T, Ishikawa A,Inoue Y,Kubota K.
    • Organizer
      41st Annual Meeting of Society for Neuroscience.
    • Place of Presentation
      Washington DC
    • Related Report
      2011 Research-status Report
  • [Presentation] シンポジウム:Brain-machine interfaceはどこまで可能か?「Real-timeNIRSによるニューロフィードバックを用いた神経リハビリテーション」2011

    • Author(s)
      三原雅史
    • Organizer
      第52回日本神経学会学術大会(招待講演)
    • Place of Presentation
      愛知
    • Related Report
      2011 Research-status Report
  • [Presentation] 脳卒中後のバランス能力回復に関与する大脳皮質領域の検討.2011

    • Author(s)
      三原雅史,服部憲明,畠中めぐみ,矢倉一,河野悌司,宮井一郎,久保田競.
    • Organizer
      第52回日本神経学会学術大会.
    • Place of Presentation
      愛知
    • Related Report
      2011 Research-status Report
  • [Book] Chapter: Applications of Near-Infrared Spectroscopy in Movement Disorders. In book: Neuroimaging of Movement Disorders;2013

    • Author(s)
      Mihara M, Hattori N, Miyai I.
    • Publisher
      Springer
    • Related Report
      2012 Final Research Report
  • [Book] Neuroimaging of Movement Disorders2013

    • Author(s)
      Masahito Mihara
    • Total Pages
      350
    • Publisher
      Springer
    • Related Report
      2012 Annual Research Report
  • [Book] Chapter: Applications of Near Infrared Spectroscopy in Neurorehabilitation. In book: Infrared Spectroscopy - Life and Biomedical Sciences;2012

    • Author(s)
      Mihara M, Miyai I
    • Publisher
      InTech
    • Related Report
      2012 Final Research Report
  • [Book] Infrared Spectroscopy - Life and Biomedical Sciences.2012

    • Author(s)
      Masahito Mihara
    • Total Pages
      368
    • Publisher
      InTech
    • Related Report
      2012 Annual Research Report
  • [Book] Applications of near infrared spectroscopy in neurorehabilitation in Infrared Spectroscopy / Book 12012

    • Author(s)
      Mihara M, Miyai I.
    • Total Pages
      16
    • Publisher
      InTech
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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