Roles of prefrontal cortex and basal ganglia in decision making based on preference

• Project/Area Number: 23700504
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Fusional social brain science
• Research Institution: Tamagawa University
• Principal Investigator: YOKOYAMA Osamu 玉川大学, 脳科学研究所, グローバルCOE研究員 (60455409)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 意思決定 / 報酬 / 好み / サル / 外側前頭前野 / 単一神経細胞活動 / 局所場電位 / 多点電極 / 神経活動 / 前頭前野 / 選択

Research Abstract

Activity of single neurons in the macaque lateral prefrontal cortex mainly represented signals related to movement that indicates the choice when the choice was determined by endogenous preference. Activities of ensemble of the neurons also represent the reward type the subject was about to choose and the neurons differed from those that signaled the target reward type when it was determined by the external cue. Therefore, neurons in the lateral prefrontal cortex changed their activity dependent on the way how the choice to be determined and may serve selection of the appropriate action.

Research Products

• [Presentation] Differential representation of goal in monkey lateral prefrontal cortex in free- and instructed-choice (2011)
  • Author(s): Osamu Yokoyama, Naotsugu Tsuchiya, Kensaku Nomoto, Atsushi Noritake, Masamichi Sakagami
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-09-17
• [Presentation] Goal representation by macaque lateral prefrontal cortex are different between internally-determined and instructed choice (2011)
  • Author(s): Osamu Yokoyama, Naotsugu Tsuchiya, Kensaku Nomoto, Atsushi Noritake, Masamichi Sakagami
  • Organizer: Socail Neuroscience Satellite at the 15th annual meeting of the Association for the Scientific Study of Consciousness (A joint Tamagawa-Caltech Lecture Course)
  • Place of Presentation: Kyoto University
  • Year and Date: 2011-06-07
• [Presentation] Goal representations by macaque lateral prefrontal cortex are different between internally-determined and instructed choice (2011)
  • Author(s): Osamu Yokoyama
  • Organizer: Social Neuroscience Satellite at the 15th annual meeting of the Association for the Scientific Study of Consciousness
  • Place of Presentation: 京都大学（京都府）
• [Presentation] Decoding goal independent of perception and action from macaque prefrontal activity during a free choice task (2011)
  • Author(s): Osamu Yokoyama
  • Organizer: 2011年度包括脳ネットワーク夏のワークショップ
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] Differential representation of goal in monkey lateral prefrontal cortex in free- and instructed-choice (2011)
  • Author(s): Osamu Yokoyama
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県）