| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Research Abstract |
We succeeded to generate rat embryo in mouse and mouse embryo in rat by interspecific tetraploid complementation using each pluripotent stem cell. Both of them, each PSC-derived embryo cannot survive in a xenogenic environment over some periods. However, we prove that the early development of completely PSC-derived embryo can be followed up in xenogenic environment. The system described here not only provides a powerful experimental tool for understanding of xenogenic barrier in early embryonic development but also an initial step toward the generation of PSC-derived animal in xenogenic environment.
|
