| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
The number of patients with chronic kidney diseases (CKD) is expected to increase steadily each year in Japan. It has not been reported the effective therapy for renal insufficiency except dialysis and transplantation. The mechanisms responsible for CKD have not been made clear yet, so that it is difficult to discover effective drugs for kidney diseases. One of the reasons for the difficulties is that suitable animal models for various kidney diseases don't exist. Therefore, in this study, I tried to find the causal genes responsible for the progression of kidney diseases and to male a novel and suitable mouse model for kidney diseases. QTL and DNA array analyses using ICGN mice, a nephrotic syndrome model, revealed that some genomic loci responsible for the progression of kidney diseases. I developed congenic mice carrying these genomic loci, and analyzed the phenotype. These strains might contributed to elucidate the mechanisms responsible for kidney diseases.
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