| Project/Area Number |
23700527
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Yokohama National University |
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Principal Investigator |
HYAKUTAKE Toru 横浜国立大学, 工学研究院, 准教授 (20335582)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 微小循環 / 酸素拡散 / 格子ボルツマン法 / 人工赤血球 / 埋め込み境界法 / 酸素輸送 |
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| Research Abstract |
Typical liposome-encapsulated hemoglobin (LEH) particles measure approximately 200-250 nm in diameter. Thus the effect of LEH will be significant at a microcirculation level, where vessel diameters are smaller than the red blood cell (RBC) diameter. Therefore, studies on RBC and LEH flow distributions at a microvessel will provide a better understanding of the effect of LEH on tissue oxygen delivery. In this study, we investigated the diffusion of oxygen and LEH in the microvessel. The simulation results showed the qualitative agreement between the simulation and the experimental data. The increase on diffusion coefficient of LEH led to the concentration diffusion to the radial direction, as a result, the oxygen concentration increased as times passed and the oxygen saturation decreased in the microvessel.
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