Development of electrical , chemical, and mechanical integration myocardial cell model to reproduce the micro flow of intracellular

• Project/Area Number: 23700530
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Nagoya University
• Principal Investigator: HIRABAYASHI Satoko 名古屋大学, 工学(系)研究科(研究院), 助教 (30566716)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 三相理論 / 有限要素法 / バイオメカニクス

Outline of Final Research Achievements

Micro flow of intracellular fluid, the cellular tissue
and ion influence mutually to show a complex phenomenon.
In this study, we examined the triphasic theory as numerical analysis method to reproduce this phenomenon . In this theory , all of the solid displacement , fluid velocity , pressure , ion current , and ion potential are unknown of coupling analysis to make the amount of calculation huge. As cells contraction is a dynamic problem, solving the simultaneous equations by splitting method is suitable for practically applying. The method can reduce substantial amount of calculation in the following three ways: by reducing unknowns of simultaneous equations; by allowing some of the equations to be solved explicitly; and by allowing some of the equations to be calculated in fine time increments.