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Development of nanoneedle array for imaging of cell functions

Research Project

Project/Area Number 23700531
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biological material science
Research InstitutionToyohashi University of Technology

Principal Investigator

KAWASHIMA Takahiro  豊橋技術科学大学, 大学院・工学研究科, 准教授 (50378270)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywordsナノニードルアレイ / 細胞機能イメージング / 多点同時計測 / BioMEMS / SICM / SNOM
Research Abstract

This research is focused on the development of nanoneedle array for cell function imaging which can realize imaging of cell morphology and of molecules expressed in cell during cell growth. In this research, an array of hollow SiO2 nanoneedles was successfully fabricated. In addition, cell morphology imaging and fluorescent imaging were examined.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Fabrication of hollow SiO_2 nanoneedle array and characterization of simultaneous multi-site ion-conductance recordings for cell morphology imaging2012

    • Author(s)
      Takahiro Kawashima, Tomoya Matsugase, Kazumasa Tanaka, Moeto Nagai, Takayuki Shibata, Takashi Mineta, Eiji Makino
    • Journal Title

      Microelectronic Engineering

      Volume: 98 Pages: 663-667

    • DOI

      10.1016/j.mee.2012.07.014

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 細胞形態イメージングのためのナノニードルアレイ搭載型多点同時計測イオンコンダクタンス顕微鏡の開発2012

    • Author(s)
      松ヶ瀬智哉,田中一匡,川島貴弘,永井萌土,柴田隆行,峯田貴,牧野英司
    • Organizer
      2012 年度精密工学会春季大会学術講演会
    • Place of Presentation
      首都大学東京(東京都)
    • Year and Date
      2012-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞形態イメージングのためのナノニードルアレイ搭載型多点同時計測イオンコンダクタンス顕微鏡の開発2012

    • Author(s)
      松ヶ瀬 智哉,田中一匡,川島貴弘,永井萌土,柴田隆行,峯田 貴,牧野英司
    • Organizer
      2012年度精密工学会春季大会学術講演会
    • Place of Presentation
      首都大学東京(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] Development of simultaneous multi-site ion conductance microscopy integrated with nanoneedle array for cell morphology imaging2011

    • Author(s)
      T. Matsugase, K. Tanaka, T.Kawashima,M. Nagai, T. Shibata, T. Mineta, E. Makino
    • Organizer
      International Workshop on Micro/Nano-Engineering
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2011-12-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞形態イメージングのための多点同時計測イオンコンダクタンス顕微鏡の開発2011

    • Author(s)
      松ヶ瀬智哉,田中一匡,川島貴弘,永井萌土,柴田隆行,峯田貴,牧野英司
    • Organizer
      第54回自動制御連合講演会
    • Place of Presentation
      豊橋技術科学大学(愛知県)
    • Year and Date
      2011-11-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of simultaneous multi-site ion-conductance microscope for imaging of cell morphology2011

    • Author(s)
      T. Kawashima,T. Matsugase,M. Nagai,T. Shibata , T. Mineta , E. Makino
    • Organizer
      37th International Conference on Micro and Nano Engineering (MNE2011)
    • Place of Presentation
      BCC Berliner Congress Center(Germany)
    • Year and Date
      2011-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of simultaneous multi-site ion-conductance microscope for imaging of cell morphology2011

    • Author(s)
      Takahiro Kawashima, Tomoya Matsugase, Moeto Nagai, Takayuki Shibata, Takashi Mineta, Eiji Makino
    • Organizer
      the 37th International Conference on Micro and Nano Engineering (MNE2011)
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2011 Research-status Report
  • [Presentation] Development of simultaneous multi-site ion conductance microscopy integrated with nanoneedle array for cell morphology imaging2011

    • Author(s)
      Tomoya Matsugase, Kazumasa Tanaka, Takahiro Kawashima, Moeto Nagai, Takayuki Shibata, Takashi Mineta, Eiji Makino
    • Organizer
      International Workshop on Micro/Nano-Engineering
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] 細胞形態イメージングのための多点同時計測イオンコンダクタンス顕微鏡の開発2011

    • Author(s)
      松ヶ瀬智哉,田中一匡,川島貴弘,永井萌土,柴田隆行,峯田 貴,牧野英司
    • Organizer
      第54回自動制御連合講演会
    • Place of Presentation
      豊橋技術科学大学(豊橋)
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://mems.me.tut.ac.jp/research.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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