Development of tumor immunotherapy based on the control of distribution and function of macrophages with DDS-type "Find-me" signals
| Project/Area Number |
23700532
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
JO Jun-ichiro 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (60511243)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 生体制御 / 治療 / ナノバイオ / 癌 / 脂質 / 生体機能応用 |
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| Research Abstract |
It has been well recognized that dead cells are effectively eliminated by macrophages based on “Find-me” signals released from dead cells. In this study, nanostructures, which enable to simultaneously include attraction (“Find-me” signals) and activation drugs of macrophages and deliver to the tumor tissue, were designed and prepared by making use of drug delivery systems (DDS) and material technologies. In addition, we evaluated the possibility and mechanism of tumor immunotherapy with the nanostructures prepared.
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Report
(3 results)
Research Products
(4 results)
