| Project/Area Number |
23700536
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka University |
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Principal Investigator |
MORITA Masahito 大阪大学, 免疫学フロンティア研究センター, 特任助教 (30381594)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ナノバイオロジー / マルチモーダルイメージング / 細胞動態 / ナノダイヤモンド / 金ナノ粒子 / ハンガリー |
|---|
| Research Abstract |
In immuno-cell therapy and inflammation process during the virus infection and cancer metastasis, it is important to evaluate the physiological function and structural change of transplanted and interested cells in vivo. So far, most studies have focused on developing multimodal imaging methods in order to simultaneously detect target cells and analyze their physiological function. In this vein, we have been attempting to develop the stable contrast agents for both MRI with fluorescence imaging. Both imaging modalities have the potential to provide complementary physiological information from micro to macro level, with low invasion compared to PET and X-ray CT. In this project, we succeeded in the synthesis of magnetic and light-responsive contrast agents.
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