| Project/Area Number |
23700540
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | Akita Prefectural University |
|---|
Principal Investigator |
YANO Tetsuya 秋田県立大学, システム科学技術学部, 助教 (70404853)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 人工心臓 / 血液ポンプ / 血流 / 溶血 / 血栓 / 数値流体解析 / 血栓形成 |
|---|
| Research Abstract |
Blood compatibility of a ventricular assist device (VAD) depends on the dynamics of blood flow. The focus in most previous studies was on blood flow in the VAD. However, the VAD inflow cannula influences the dynamics of blood flow and thus thrombus formation in the ventricle. In order to clarify the blood flow in the left ventricle (LV) supported with a continuous flow type VAD (CFVAD), the flow was analyzed by means of numerical and experimental fluid dynamics. Assessment based on average wall shear stress on the LV wall indicated that some of the combinations of the catheter tip shape and insertion depth improved the washout effect. The blood flow in the LV partially supported with a CFVAD was calculated. The change of flow pattern due to the LV ejection fraction, type of VAD and pump performance was confirmed. In addition, a simple method to assess the fragility of blood cells was proposed. The method is valuable to inspect the quality of the blood cells used for hemolysis tests.
|
