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Process design for producing biomedical β-type titanium alloys with high biocompatibility

Research Project

Project/Area Number 23700553
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biological material science
Research InstitutionTohoku University

Principal Investigator

NAKAI Masaaki  東北大学, 金属材料研究所, 准教授 (20431603)

Research Collaborator TODAKA Yoshikazu  豊橋技術科学大学, 工学研究科, 准教授 (50345956)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsチタン合金 / 強加工 / 耐食性 / 細胞毒性
Research Abstract

A specific phase that is not etched during etching because of higher corrosion resistance to an etching solution is formed in a biomedical β-type titanium alloy, Ti-29Nb-13Ta-4.6Zr, subjected to high pressure torsion. Higher corrosion resistance of the specific phase than that of matrix was elucidated in this study. It is found that the alloying element distribution in the specific phase is different from that in the matrix; the alloying element is distributed more homogeneously in the specific phase than the matrix. This homogeneous element distribution is considered to be obtained by strong mechanical stir of high pressure torsion, and to cause higher corrosion resistance of the specific phase than that of the matrix.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (21 results) (of which Invited: 2 results)

  • [Journal Article] Heterogeneous grain refinement of biomedical Ti-29Nb-13Ta-4.6Zr alloy through high-pressure torsion2013

    • Author(s)
      M. Nakai, M. Niinomi, J. Hieda, H. Yilmazer and Y. Todaka
    • Journal Title

      Scientia Iranica

      Volume: in press Pages: 1067-1070

    • DOI

      10.1016/j.scient.2013.01.004

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanical properties of a medical β-type titanium alloy with specific microstructural evolution through high-pressure torsion2013

    • Author(s)
      H. Yilmazer, M. Niinomi, M. Nakai, K.Cho, J. Hieda, Y. Todaka and T. Miyazaki
    • Journal Title

      Mater. Sci. Eng. C

      Volume: 30 Issue: 5 Pages: 2499-2507

    • DOI

      10.1016/j.msec.2013.01.056

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Corrosion resistance of Ti-29Nb-13Ta-4.6Zr alloy in a fluoride-containing solution2013

    • Author(s)
      S. Takemoto, M. Nakai, M. Hattori, M. Yoshinari, E. Kawada, M. Niinomi and Y. Oda
    • Journal Title

      Key Engineering Materials

      Volume: 529-530 Pages: 584-587

    • DOI

      10.4028/www.scientific.net/kem.529-530.584

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of new metallic alloys for biomedical applications2012

    • Author(s)
      M. Niinomi, M. Nakai and J. Hieda
    • Journal Title

      ActaBiomater

      Volume: 8 Issue: 11 Pages: 3888-3903

    • DOI

      10.1016/j.actbio.2012.06.037

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microstructure and mechanical properties of a biomedical β-type titanium alloy subjected to severe plastic deformation after aging treatment2012

    • Author(s)
      H. Yilmazer, M. Niinomi, M. Nakai, J.Hieda, T. Akahori and Y. Todaka
    • Journal Title

      Key Eng. Mater

      Volume: 508 Pages: 152-160

    • DOI

      10.4028/www.scientific.net/kem.508.152

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heterogeneous structure and mechanical hardness of biomedical β-type Ti-29Nb-13Ta-4.6Zr subjected to high-pressure torsion2012

    • Author(s)
      H. Yilmazer, M. Niinomi, M. Nakai, J.Hieda, Y. Todaka, T. Akahori and T. Miyazaki
    • Journal Title

      J. Mech. Behav. Biomed. Mater

      Volume: 10 Pages: 235-245

    • DOI

      10.1016/j.jmbbm.2012.02.022

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of high-pressure torsion processing on microstructure and mechanical properties of a novel biomedical β-type Ti-29Nb-13Ta-4.6Zr after cold rolling2012

    • Author(s)
      H. Yilmazer, M. Niinomi, T. Akahori, M. Nakai and Y. Todaka
    • Journal Title

      International Journal of Microstructure and Materials Properties

      Volume: 7 Issue: 2/3 Pages: 168-186

    • DOI

      10.1504/ijmmp.2012.047498

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Microstructure evaluation of biomedical β-type titanium alloysthrough high-pressure torsion by X-ray diffraction line profile analysis2013

    • Author(s)
      H. Yilmazer, M. Niinomi, K. Cho, M.Nakai, J. Hieda, Y. Todaka and S. Sato
    • Organizer
      日本金属学会 2013 年春期(第152回)大会
    • Place of Presentation
      東 京理科大学
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of mechanical biocompatibility of low-modulus beta-type titanium alloy by introducing ultrafine-grain structure through high-pressure torsion2013

    • Author(s)
      M. Niinomi, M. Nakai, J. Hieda, K. Cho, H. Yelmazer and Y. Todaka
    • Organizer
      TMS 2013 142nd Annual Meeting& Exhibition
    • Place of Presentation
      San Antonio, Texas, USA (招待講演).
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of mechanical biocompatibility of low-modulus beta-type titanium alloy by introducing ultrafine-grain structure through high-pressure torsion2013

    • Author(s)
      M. Niinomi, M. Nakai, J. Hieda, K. Cho, H. Yelmazer and Y. Todaka
    • Organizer
      TMS 2013 142nd Annual Meeting & Exhibition
    • Place of Presentation
      San Antonio, Texas, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Microstructure evaluation of biomedical β-type titanium alloys through high-pressure torsion by X-ray diffraction line profile analysis2013

    • Author(s)
      H. Yilmazer, M. Niinomi, K. Cho, M. Nakai, J. Hieda, Y. Todaka and S. Sato
    • Organizer
      日本金属学会2013年春期(第152回)大会
    • Place of Presentation
      東京理科大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effect of microstructural control by severe plastic deformation on mechanical behavior of β-type titanium alloys2012

    • Author(s)
      H. Yilmazer, M. Niinomi, K. Cho, M.Nakai, J. Hieda and Y. Todaka
    • Organizer
      第11回日本金属学会東北支部研究発表大会
    • Place of Presentation
      東北大学
    • Year and Date
      2012-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Improvement of mechanical strength of titanium alloys by microstructural refinement down to nano-size through high pressure torsion2012

    • Author(s)
      M. Niinomi, M. Nakai, J. Hieda and K.Cho
    • Organizer
      21th International Symposium on Processing and Fabrication of Advanced Materials (PFAM XXI)
    • Place of Presentation
      Guwahati, Assam, India (基調講演)
    • Related Report
      2012 Final Research Report
  • [Presentation] 高圧ねじり加工を用いた微細組織制御による生体用Ti-29Nb-13Ta-4.6Zr合金の力学的生体適合性向上2012

    • Author(s)
      趙研,新家光雄,仲井正昭,稗田純子,H.Yilmazer,戸高義一
    • Organizer
      日本機械学会機械材料・材料加工部門第20回機械材料・材料加工技術講演会(M&P2012)
    • Place of Presentation
      大阪工業大学
    • Related Report
      2012 Final Research Report
  • [Presentation] Microstructural evaluation of β-type Ti-29Nb-13Ta-4.6Zr through high-pressure torsion after cold rolling and aging treatment2012

    • Author(s)
      H. Yilmazer, M. Niinomi, K. Cho, M.Nakai, J. Hieda and Y. Todaka
    • Organizer
      日本機械学会 機械材料・材料加工部門 第20回機械材料・材料加工技術講演会(M&P2012)
    • Place of Presentation
      大阪工業大学
    • Related Report
      2012 Final Research Report
  • [Presentation] フッ化物溶液に浸漬したTi-Nb-Ta-Zr合金の表面分析2012

    • Author(s)
      武本真治,仲井正昭,服部雅之,河田英司,吉成正雄,新家光雄,小田豊
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台国際センター
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Corrosion resistance of Ti-29Nb-13Ta-4.6Zr alloy in a fluoride-containing solution2012

    • Author(s)
      S. Takemoto, M. Nakai, M. Hattori, M.Yoshinari, E. Kawada, M. Niinomi and Y. Oda
    • Organizer
      24th Symposium and Annual Meeting of International Society for Ceramics in Medicine (ISCM) (Bioceramics 24)
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] フッ化物溶液中でのTi-Nb-Ta-Zr合金の電気化学腐食挙動2012

    • Author(s)
      武本真治,仲井正昭,服部雅之,市川弘道,五十嵐俊男,吉成正雄,河田英司,新家光雄,小田豊
    • Organizer
      平成24年度秋期第60回日本歯科理工学会学術講演会
    • Place of Presentation
      九州大学
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 高圧ねじり加工を用いた生体用β型チタン合金の力学的生体適合性向上2012

    • Author(s)
      趙研,新家光雄,仲井正昭,稗田純子,H.Yilmazer,戸高義一
    • Organizer
      日本金属学会2012年秋期(第151回)大会
    • Place of Presentation
      愛媛大学
    • Related Report
      2012 Final Research Report
  • [Presentation] Improvement of mechanical strength of titanium alloys by microstructural refinement down to nano-size through high pressure torsion2012

    • Author(s)
      M. Niinomi, M. Nakai, J. Hieda and K. Cho
    • Organizer
      21th International Symposium on Processing and Fabrication of Advanced Materials (PFAM XXI)
    • Place of Presentation
      Guwahati, Assam, India
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 高圧ねじり加工を用いた生体用β型チタン合金の力学的生体適合性向上2012

    • Author(s)
      趙研, 新家光雄, 仲井正昭, 稗田純子, H. Yilmazer, 戸高義一
    • Organizer
      日本金属学会2012年秋期(第151回)大会
    • Place of Presentation
      愛媛大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高圧ねじり加工を用いた微細組織制御による生体用Ti-29Nb-13Ta-4.6Zr合金の力学的生体適合性向上2012

    • Author(s)
      趙研, 新家光雄, 仲井正昭, 稗田純子, H. Yilmazer, 戸高義一
    • Organizer
      日本機械学会 機械材料・材料加工部門 第20回機械材料・材料加工技術講演会 (M&P2012)
    • Place of Presentation
      大阪工業大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Microstructural evaluation of β-type Ti-29Nb-13Ta-4.6Zr through high-pressure torsion after cold rolling and aging treatment2012

    • Author(s)
      H. Yilmazer, M. Niinomi, K. Cho, M. Nakai, J. Hieda and Y. Todaka
    • Organizer
      日本機械学会 機械材料・材料加工部門 第20回機械材料・材料加工技術講演会 (M&P2012)
    • Place of Presentation
      大阪工業大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Microstructure and mechanical properties of a biomedical β-type titanium alloy subjected to severe plastic deformation after aging treatment2011

    • Author(s)
      H. Yilmazer, M. Niinomi, M. Nakai, J.Hieda, T. Akahori and Y. Todaka
    • Organizer
      International Symposium of GCOE: Materials Integration
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] Heterogeneous grain refinement of biomedical Ti-29Nb-13Ta-4.6Zr alloy through high-pressure torsion2011

    • Author(s)
      M. Nakai, M. Niinomi, J. Hieda, H.Yilmazer and Y. Todaka
    • Organizer
      The 3rd International Conference on UltraFine Grained and Nano-Structured Materials (UFGNSM 2011)
    • Place of Presentation
      Tehran, Iran
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] Mechanical performances of biomedical beta-typetitanium alloy through heat treatment and severe plastic deformation2011

    • Author(s)
      T. Akahori, M. Niinomi, M. Nakai, H.Yilmazer and H. Fukui
    • Organizer
      Materials and Processes for Medical Devices (MPMD) Conference and Exposition
    • Place of Presentation
      Minneapolis, MN, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Mechanical performances of biomedical beta-type titanium alloy through heat treatment and severe plastic deformation2011

    • Author(s)
      T. Akahori, M. Niinomi, M. Nakai, H. Yilmazer and H. Fukui
    • Organizer
      Materials and Processes for Medical Devices (MPMD) 2011 Conference and Exposition
    • Place of Presentation
      Minneapolis, MN, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Effect of microstructural control by severe plastic deformation on mechanical behavior of β-type titanium alloys

    • Author(s)
      H. Yilmazer, M. Niinomi, K. Cho, M. Nakai, J. Hieda and Y. Todaka
    • Organizer
      第11回日本金属学会東北支部研究発表大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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