Evaluation and functionalization of Tetra-PEG gels as medical structural materials

• Project/Area Number: 23700555
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: The University of Tokyo
• Principal Investigator: SAKAI Takamasa 東京大学, 大学院・工学系研究科, 助教 (70456151)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ハイドロゲル / Tetra-PEG ゲル / 医用構造材料 / 生分解性 / 高分子ゲル / Tetra-PEGゲル / 生体構造材料 / 生体材料 / 精密構造制御

Research Abstract

In order to apply Tetra-PEG gel for biomedical structural materials, we evaluated the biocompativility and drug releasing behavior, and introduced the biodegradability to Tetra-PEG gel. We confirmed the biocompatibility of raw material, gelation reaction, and formed gels. We investigated the release of model drugs from Tetra-PEG gels, and clarified the effect of mesh size on the drug releasing behavior. We designed the novel molecules and succeeded in the fabrication of biodegradable Tetra-PEG gels.

Research Products

• [Journal Article] Solvation Structure of Poly(ethylene glycol) in Ionic Liquids Studied by High-energy X-ray Diffraction and Molecular Dynamics Simulations (2013)
  • Author(s): Asai, H.; Umebayashi, Y. (6) et al. (7)
  • Journal Title: Macromolecules Volume: 46(6) Issue: 6 Pages: 2369-2375
  • DOI: 10.1021/ma400218e
  • Peer Reviewed
• [Journal Article] Transition between phantom and affine network model observed in polymer gels with controlled network structure (2013)
  • Author(s): Yuki Akagi, et al.
  • Journal Title: Macromolecules Volume: 46 Issue: 3 Pages: 1035-1040
  • DOI: 10.1021/ma302270a
  • Peer Reviewed
• [Journal Article] Gelation process of Tetra-PEG ion-gel investigated by time-resolved dynamic light scattering (2013)
  • Author(s): H. Asai, K. Nishi, T. Hiroi, K. Fujii, T.Sakai and M. Shibayama
  • Journal Title: Polymer Volume: 54 Pages: 1160-1166
  • URL: http://dx.doi.org/10.1016/j.polymer.2012.12.053
  • Peer Reviewed
• [Journal Article] Mechanical propert ies of a polymer network of Tetra-PEG gel (2013)
  • Author(s): Asumi Sugimura, et al.
  • Journal Title: Polymer Journal Volume: 45 Issue: 3 Pages: 300-306
  • DOI: 10.1038/pj.2012.149
  • Peer Reviewed
• [Journal Article] Rubber Elasticity for Incomplete Polymer Networks (2012)
  • Author(s): Nishi, K., Chijiishi, M., Katsumoto, Y., Nakao, T., Fujii, K., Chung, U., Noguchi, H., Sakai, T., Shibayama, M., J.Chem.
  • Journal Title: Phys Volume: 137 Issue: 22 Pages: 224903-224903
  • DOI: 10.1063/1.4769829
  • Peer Reviewed
• [Journal Article] Anomalous volume phase transition in a polymer gel with alternativehydrophilic-amphiphilic sequence (2012)
  • Author(s): Kamata, H., Chung, U., Shibayama, M., Sakai, T.,
  • Journal Title: Soft Matter Volume: 8 Issue: 26 Pages: 2876-2879
  • DOI: 10.1039/c2sm25168j
  • Peer Reviewed
• [Journal Article] Strain energy density function of a near-ideal polymer network estimated by biaxial deforlation of Tetra-PEG gel (2012)
  • Author(s): T. Katashima, et al.
  • Journal Title: Soft Matter Volume: 31 Issue: 31 Pages: 8217-8222
  • DOI: 10.1039/c2sm25340b
  • Peer Reviewed
• [Journal Article] Development and evaluation of tetrapod-shaped granular artificial bones (2012)
  • Author(s): Sungjin Choi
  • Journal Title: Acta Biomaterialia Volume: (掲載確定済) Issue: 6 Pages: 2340-2347
  • DOI: 10.1016/j.actbio.2012.02.019
  • Peer Reviewed
• [Journal Article] Effect of swelling and deswelling on the elasticity of polymer networks in the dilute to semi-dilute region (2012)
  • Author(s): Sakai, T., Kurakazu, M., Akagi, Y., Shibayama, M., Chung, U.
  • Journal Title: Soft Matter Volume: 8 Issue: 9 Pages: 2730-2736
  • DOI: 10.1039/c2sm07043j
  • Peer Reviewed
• [Journal Article] Kinetic Study for AB-Type Coupling Reaction of Tetra-Arm Polymers (2012)
  • Author(s): Nishi, K., Fujii, K., Chijiishi, M., Katsumoto, Y., Chung, U., Sakai, T., Shibayama, M.
  • Journal Title: Macromolecules Volume: 45 Issue: 2 Pages: 1031-1036
  • DOI: 10.1021/ma202386k
  • Peer Reviewed
• [Journal Article] High-performance ion gel with tetra-PEG network (2012)
  • Author(s): K.Fujii, H.Asai, T.Ueki (equally contributed), T.Sakai, S.Imaizumi, U.-I.Chung, M.Watanabe, M.Shibayama
  • Journal Title: Soft Matter Volume: 8 Issue: 6 Pages: 1756-1759
  • DOI: 10.1039/c2sm07119c
  • Peer Reviewed
• [Journal Article] Precise Control and Prediction of Hydrogel Degradation Behavior (2011)
  • Author(s): Li, X., Tsutsui, Y., Matsunaga, T., Shibayama, M., Chung, U., Sakai, T.
  • Journal Title: Macromolecules Volume: 44 Issue: 9 Pages: 3567-3571
  • DOI: 10.1021/ma2004234
  • Peer Reviewed
• [Journal Article] State of Water, Molecular Structure, and Cytotoxicity of Silk Hydrogels (2011)
  • Author(s): K. Numata, T. Katashima, T. Sakai
  • Journal Title: Biomacromolecules Volume: 12 Issue: 6 Pages: 2137-2144
  • DOI: 10.1021/bm200221u
  • Peer Reviewed
• [Journal Article] Examination of the Theories of Rubber Elasticity Using an Ideal Polymer Network (2011)
  • Author(s): Akagi, Y., Katashima, T., Katsumoto, Y., Fujii, K., Matsunaga, T., Chung, U., Shibayama, M., Sakai, T.
  • Journal Title: Macromolecules Volume: 44 Issue: 14 Pages: 5817-5821
  • DOI: 10.1021/ma201088r
  • Peer Reviewed
• [Journal Article] Connectivity and Structural Defects in Model Hydrogels: A Combined Proton NMR and Monte Carlo Simulation Study (2011)
  • Author(s): F. Lange, K. Schwenke, M. Kurakazu, Y.Akagi, U. Chung, M. Lane, J. Sommer, T. Sakai, K. Saalwachter
  • Journal Title: Macromolecules Volume: 44 Issue: 24 Pages: 9666-9674
  • DOI: 10.1021/ma201847v
  • Peer Reviewed
• [Journal Article] Structure and physical properties of dried Tetra-PEG gel (2011)
  • Author(s): Y. Nomoto, T. Matsunaga, T. Sakai, M.Tosaka, M. Shibayama
  • Journal Title: Polymer Volume: 52 Pages: 4123-4128
  • URL: http://dx.doi.org/10.1016/j.polymer.2011.06.053
  • Peer Reviewed
• [Presentation] Tetra-PEGゲルのバイマテリアルへの応用へ向けた試み (2012)
  • Author(s): 酒井崇匡
  • Organizer: 第47回高分子学会筑波地区活動講演会
  • Place of Presentation: つくば市,茨城県
  • Year and Date: 2012-11-08
• [Presentation] 四分岐ポリマーからなるTetra-PEGゲルにおける構造解析と物性との相関 (2012)
  • Author(s): 酒井崇匡
  • Organizer: 精密ネットワークポリマー研究会
  • Place of Presentation: 目黒区,東京都
  • Year and Date: 2012-04-20
• [Presentation] Tetra-PEGケ〓ルの分解挙動の精密制御 (2012)
  • Author(s): リキョウ、筒井裕亮、鄭雄一、酒井崇匡
  • Organizer: 理化学研究所・若手勉強会
  • Place of Presentation: 横浜市,神奈川県
  • Year and Date: 2012-01-27
• [Presentation] Tetra-PEGゲルの力学特性に及ぼす網目構造の影響 (2012)
  • Author(s): 酒井崇匡
  • Organizer: つくばソフトマター研究会
  • Place of Presentation: 那珂郡,茨城県
• [Presentation] Evaluation of the mechanical properties and structure of a polymer network formed by cross-end coupling (2012)
  • Author(s): Yuki Akagi, Ung-il Chung, Takamasa Sakai
  • Organizer: nanobaio seattle2012
  • Place of Presentation: Seattle, USA
• [Presentation] 高分子網目形成に及ぼすプレポリマー分岐構造の影響 (2012)
  • Author(s): 石原俊也,鄭雄一,酒井崇匡
  • Organizer: 田中豊一記念シンポジウム2012
  • Place of Presentation: 江別市,北海道
• [Presentation] Tetra-PEG gelの二軸延伸による理想網目構造の歪エネルギー密度関数の推定 (2012)
  • Author(s): 片島拓弥,浦山健治,鄭雄一,酒井崇匡
  • Organizer: 田中豊一記念シンポジウム2012
  • Place of Presentation: 江別市,北海道
• [Presentation] Tetra-PEG Gelの最大変形率に及ぼす構造パラメータの影響 (2012)
  • Author(s): 赤木友紀,片島拓弥,鄭雄一,酒井崇匡
  • Organizer: 田中豊一記念シンポジウム2012
  • Place of Presentation: 江別市,北海道
• [Presentation] 高分子網目における網目サイズの不均一分布が力学特性に及ぼす影響 (2012)
  • Author(s): 近藤真司、酒井崇匡、鄭雄一
  • Organizer: 田中豊一記念シンポジウム2012
  • Place of Presentation: 江別市,北海道
• [Presentation] Evaluation of the mechanical properties and structure of a polymer network formed by cross-end coupling (2012)
  • Author(s): Yuki Akagi, Ung-il Chung, Takamasa Sakai
  • Organizer: SIMS2012
  • Place of Presentation: Tsukuba, Ibaragi.
• [Presentation] Application of Tetra-PEG gel as a high-performance separation medium for biomolecules (2012)
  • Author(s): Xian Li
  • Organizer: 9th International Gel Symposium “Gelsympo 2012”
  • Place of Presentation: つくば市、つくば国際会議場
• [Presentation] 高い均一性を有するTetra-PEGゲルの合成と応用 (2011)
  • Author(s): 酒井崇匡
  • Organizer: 第21回高分子ゲル研究会講座
  • Place of Presentation: 新宿区,東京都
  • Year and Date: 2011-11-18
• [Presentation] Tetra-PEGゲルの構造と物性の相関とその応用 (2011)
  • Author(s): 酒井崇匡
  • Organizer: 高分子ゲルワークショップ
  • Place of Presentation: 岡山市,岡山県
• [Presentation] Tetra-PEGケ〓ルの分解挙動の精密制御 (2011)
  • Author(s): リキョウ、筒井裕亮、鄭雄一、酒井崇匡
  • Organizer: 高分子ゲルワークショップ
  • Place of Presentation: 岡山市,岡山県
• [Presentation] Tetra-PEGケ〓ルの分解挙動の精密制御 (2011)
  • Author(s): リキョウ、筒井裕亮、鄭雄一、酒井崇匡
  • Organizer: 第60回高分子学会討論会
  • Place of Presentation: 岡山市,岡山県
• [Presentation] 高分子ゲルの構造に及ぼす結合欠陥の影響 (2011)
  • Author(s): 千々石雅志、西健吾、赤木友紀、勝本之晶、藤井健太、柴山充弘、鄭雄一、酒井崇匡
  • Organizer: 第60回高分子学会討論会
  • Place of Presentation: 岡山市,岡山県
• [Presentation] Tetra-PEGゲルを用いたゴム弾性の分子論的研究 (2011)
  • Author(s): 片島拓弥、鄭雄一、酒井崇匡
  • Organizer: 第60回高分子学会討論会
  • Place of Presentation: 岡山市,岡山県
• [Presentation] ゲルの構造形成に及ぼすプレポリマー分岐数の効果 (2011)
  • Author(s): 赤木友紀、石原峻也、藤井健太、松永拓郎、柴山充弘、鄭雄一、酒井崇匡
  • Organizer: 第60回高分子学会討論会
  • Place of Presentation: 岡山市,岡山県
• [Presentation] 四分岐ポリマーからなるTetra-PEGゲルの構造と物性 (2011)
  • Author(s): 酒井崇匡
  • Organizer: 2011年度繊維学会年次大会
  • Place of Presentation: 江戸川区,東京都
• [Presentation] Tetra-PEGケ〓ルの分解挙動の精密制御 (2011)
  • Author(s): リキョウ、筒井裕亮、鄭雄一、酒井崇匡
  • Organizer: 第60回高分子学会年次大会
  • Place of Presentation: 大阪市,大阪府
• [Presentation] ゲルの構造形成に及ぼすプレポリマー形状の効果 (2011)
  • Author(s): 片島拓弥、近藤真司、鄭雄一、酒井崇匡
  • Organizer: 第60回高分子学会年次大会
  • Place of Presentation: 大阪市,大阪府
• [Presentation] ゲルの構造形成に及ぼすプレポリマー分岐数の効果 (2011)
  • Author(s): 赤木友紀、柴山充弘、鄭雄一、酒井崇匡
  • Organizer: 第60回高分子学会年次大会
  • Place of Presentation: 大阪市,大阪府
• [Presentation] Tetra-PEG ゲルの分解挙動の精密制御 (2011)
  • Author(s): リキョウ、筒井裕亮、鄭雄一、酒井崇匡、
  • Organizer: 第60回高分子年次大会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Tetra-PEG ゲルの分解挙動の精密制御 (2011)
  • Author(s): リキョウ、筒井裕亮、鄭雄一、酒井崇匡
  • Organizer: 第60回高分子討論会
  • Place of Presentation: 岡山大学
• [Presentation] Tetra-PEGゲルのバイマテリアルへの応用へ向けた試み
  • Author(s): 酒井崇匡
  • Organizer: 第47回高分子学会筑波地区活動講演会
  • Place of Presentation: つくば市、JSR筑波研究所
  • Invited
• [Remarks]
  • URL: http://www.tetrapod.t.u-tokyo.ac.jp/sakai/saito/Main.html
• [Patent(Industrial Property Rights)] イオン液体含有ゲルの製造方法 (2012)
  • Inventor(s): 鄭雄一、酒井崇匡、柴山充弘、藤井 健太
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Industrial Property Number: 2012-078853
  • Filing Date: 2012-03-30
• [Patent(Industrial Property Rights)] イオン液体含有ゲル状組成物、ゲル状 薄膜、及びその製造方法 (2011)
  • Inventor(s): 鄭雄一、酒井崇匡、柴山充弘、上木 岳士、藤井健太、渡邉正義
  • Industrial Property Rights Holder: 国立大学法人東京大学、国立大学法 人横浜国立大学
  • Industrial Property Number: 2011-198851
  • Filing Date: 2011-09-12