Development of protein nanocage for siRNA delivery
Project/Area Number |
23700561
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biomedical engineering/Biological material science
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Research Institution | Kyushu University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 薬物伝達システム / siRNA / ナノバイオテクノロジー / タンパク質化学 / 分子認識 / DDS |
Research Abstract |
In this project, I tried preparing functionalized sHsp16.5 as a drug career. I fused sHsp16.5 with a tag which directed proteins to degradation in cells and some results indicated that the tag could work properly.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Liver cell specific targeting by the preS1 domain of hepatitis B virus surface antigen displayed on protein nanocages2012
Author(s)
Masaharu Murata, Sayoko Narahara, Kaori Umezaki, Riki Toita, Shigekazu Tabata, Jing Shu Piao, Kana Abe, Jeong-Hun Kang, Kenoki Oouchida, Lin Cui, Makoto Hashizume
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Journal Title
International Journal of Nanomedicine
Volume: 7
Pages: 4353-4362
DOI
Related Report
Peer Reviewed
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