Preparation of nano-vaccine carrier for precise control of immuneResponses by co-delivery of protein and gene
| Project/Area Number |
23700563
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
YUBA Eiji 大阪府立大学, 大学院・工学研究科, 助教 (80582296)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 薬物伝達システム / ワクチン / がん免疫治療 / pH応答性高分子 / リポソーム / 膜融合 / 樹状細胞 / 細胞質デリバリー / 遺伝子 / 細胞障害性T細胞 / ナノワクチン |
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| Research Abstract |
In this study, we developed novel nano-vaccine carrier by complexion of cationic lipid-pDNA complex with antigenic protein-loaded liposome modified with fusogenic polymers. This nano-carrier achieved co-delivery of antigenic protein and gene into immune cells and high levels of immune responses which can regress tumor burden of mice. Therefore, such a multi delivery nano-vaccine carrier is promising as an antigen carrier for cancer immunotherapy.
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Report
(3 results)
Research Products
(80 results)
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[Journal Article] Assemblies of polyamidoamine dendron-bearing lipids with various generations: their morphologies and abilities of gene transfection2013
Author(s)
S. Iwashita, Y. Hiramatsu, T. Otani, C. Amano, M. Hirai, H. Minematsu, H. Kitagawa, K. Oie, E. Yuba, K. Kono, M. Miyamoto, K. Igarashi
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Journal Title
J. Biomaterials Applications
Volume: 27
Issue: 4
Pages: 445-456
DOI
Related Report
Peer Reviewed
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[Journal Article] Assemblies of polyamidoamine dendron-bearing lipids with various generations:their morpho logies and abilities of gene trans fection2012
Author(s)
S. Iwashita, Y. Hiramatsu, T. Otani, C. Amano, M. Hirai, H. Minematsu, H. Kitagawa, K. Oie, E. Yuba, K. Kono, M. Miyamoto, K. Igarashi
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Journal Title
J. Biomater. Appl
Volume: 27
Pages: 445-456
Related Report
Peer Reviewed
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