| Project/Area Number |
23700563
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
YUBA Eiji 大阪府立大学, 大学院・工学研究科, 助教 (80582296)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 薬物伝達システム / ワクチン / がん免疫治療 / pH応答性高分子 / リポソーム / 膜融合 / 樹状細胞 / 細胞質デリバリー / 遺伝子 / 細胞障害性T細胞 / ナノワクチン |
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| Research Abstract |
In this study, we developed novel nano-vaccine carrier by complexion of cationic lipid-pDNA complex with antigenic protein-loaded liposome modified with fusogenic polymers. This nano-carrier achieved co-delivery of antigenic protein and gene into immune cells and high levels of immune responses which can regress tumor burden of mice. Therefore, such a multi delivery nano-vaccine carrier is promising as an antigen carrier for cancer immunotherapy.
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