| Project/Area Number |
23700567
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
WANG XIUPENG 独立行政法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 主任研究員 (70598789)
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| Co-Investigator(Renkei-kenkyūsha) |
ITO Atsuo 独立行政法人 産業技術総合研究所, 研究グループ長 (30356480)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | アジュバント / 癌免疫 / 免疫 / 腫瘍免疫 / 癌ワクチン / 免疫補助療法 / リン酸カルシウム / シグナル物質 / 細胞毒性 |
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| Research Abstract |
Zn-, and Mg-containing tricalcium phosphates (TCP) and mesoporous silica (MS) with controllable pore size were selected as carriers for immune stimulating molecules (pathogen-associated molecular patterns-PAMPs). Using a PAMPs-containing supersaturated calcium phosphate solution, PAMPs-apatite composites were coprecipitated with TCP/MS to prepare the TCP/MS based adjuvants.
The TCP/MS based adjuvants showed in vitro and in vivo immunogenic activities. The TCP/MS based adjuvants mixed with liquid-nitrogen-treated tumor tissue markedly inhibited the in vivo development of rechallenged Lewis lung carcinoma cells. The cellular immune related cytokines (IL-2, IFNr, etc.) secretion in spleen and lymphocytes were improved after the TCP/MS based adjuvants injection. The TCP/MS based adjuvants contributed to eliciting cellular immune related antitumor immunity in vivo.
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