| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
The objective of study is to develop non-invasive and continuous diagnosis of bleeding and thrombosis in extracorporeal circulation therapies such as percutaneous cardiopulmonary support and extracorporeal membrane oxygenation. Visible or near-infrared light is useful tool to diagnose blood condition or components non-invasively. To achieve the quantitative optical methods, we developed (1) the photon propagation model of flowing blood in the extracorporeal circuit tubing, (2) the plasma surface reflectance spectroscopy (PSRS) to quantify the plasma component in whole blood, and (3) the imaging method of thrombus formation in a rotary blood pump. As a result, the developed model predicted the hematocrit level within 1% error rate. The PSRS method quantified the plasma free hemoglobin level at the accuracy of 5 mg/dL. The thrombus formation in the rotary blood pump was imaged non-invasively by near-infrared hyperspectral imaging.
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