Development of Computer-aided Diagnosis Scheme on BreastUltrasonography and Its Application for Clinical Practice

• Project/Area Number: 23700578
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: Mie University
• Principal Investigator: NAKAYAMA Ryohei 三重大学, 医学部附属病院, 助教 (20402688)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 画像診断システム / 病理組織型 / 乳房超音波検査 / computer-aided diagnosis / breast mass / histological / ultrasonographic image

Research Abstract

We developed a CADx (Computer-aided Diagnosis) scheme for determining histological classification of breast mass on ultrasonographic images. We then confirmed that the CADx scheme improved the clinicians' performance significantly in an observer study.

Research Products

• [Journal Article] Improved Differential Diagnosis of Breast Masses on Ultrasonographic Images with a Computer-aided Diagnosis Scheme for Determining Histological Classifications (2013)
  • Author(s): Kashikura Y, Nakayama R, Hizukuri A, Noro A, Nohara Y, Nakamura T, Ito M, Kimura H, Yamashita M, Hanamura N, Ogawa T
  • Journal Title: Academic Radiology Volume: 20(4) Pages: 471-477
• [Journal Article] Computerized Determination Scheme for Histological Classification of Breast Mass Using Objective Features Corresponding to Clinicians' Subjective Impressions on Ultrasonographic Images. (2013)
  • Author(s): Hizukuri A, Nakayama R, Kashikura Y, Takase H, Kawanaka H, Ogawa T, Tsuruoka S
  • Journal Title: Journal of Digital Imaging Volume: Apr Issue: 5 Pages: 1-13
  • DOI: 10.1007/s10278-013-9594-7
  • Peer Reviewed
• [Journal Article] Improved Differential Diagnosis of Breast Masses on Ultrasonographic Images with a Computer-aided Diagnosis Scheme for Determining Histological Classifications. (2013)
  • Author(s): Kashikura Y, Nakayama R, Hizukuri A, Noro A, Nohara Y, Nakamura T, Ito M, Kimura H, Yamashita M, Hanamura N, Ogawa T
  • Journal Title: Academic Radiology Volume: 20(4) Issue: 4 Pages: 471-477
  • DOI: 10.1016/j.acra.2012.11.007
  • Peer Reviewed
• [Journal Article] Computerized Classification Method for Histological Classifications of Masses using Objective Features Based on Clinicians' Subjective Impressions. Proc. of the 6th International Conference on Soft Computing and Intelligent Systems and The 13th International Symposium on Advanced Intelligent Systems (2012)
  • Author(s): Hizukuri A, Nakayama R, Kashikura Y, Kawanaka H, Takase H, Ogawa T, Tsuruoka S
  • Journal Title: Kobe
• [Journal Article] Computer-aided Diagnosis Scheme for Determining Histological Classification of Breast Masses Using Clinical Features and Texture Features. Proc. of the Fourth International Workshop on Regional Innovation Studies - Biomedical Engineering - (2012)
  • Author(s): Hizukuri A, Nakayama R, Kashikura Y, Kawanaka H, Takase H, Ogawa T, Tsuruoka S
  • Journal Title: Tsu Pages: 83-86
• [Journal Article] Computerized Segmentation Method for Individual Calcifications within Clustered Microcalcifications while Maintaining Their Shapes on Magnification Mammograms (2012)
  • Author(s): Hizukuri A, Nakayama R, Nakako N, Kawanaka H, Takase H, Yamamoto K, TsuruokaS
  • Journal Title: Journal of Digital Imaging Volume: 25(3) Pages: 377-386
• [Journal Article] Computer-aided Detection Scheme for Sentinel Lymph Nodes in Lymphoscintigrams Using Symmetrical Property around Mapped Injection Point (2012)
  • Author(s): Nakayama R, Hizukuri A, Yamamoto K, Nakako N, Nagasawa N, Takeda K
  • Journal Title: Journal of Digital Imaging Volume: 25(1) Pages: 148-154
• [Journal Article] Computerized Classification Method for Histological Classifications of Masses using Objective Features Based on Clinicians’ Subjective Impressions. (2012)
  • Author(s): Hizukuri A, Nakayama R, Kashikura Y, Kawanaka H, Takase H, Ogawa T, Tsuruoka S.
  • Journal Title: Proc. of the 6th International Conference on Soft Computing and Intelligent Systems and The 13th International Symposium on Advanced Intelligent Systems Volume: 1 Pages: 1-4
  • Peer Reviewed
• [Journal Article] Computer-aided Diagnosis Scheme for Determining Histological Classification of Breast Masses Using Clinical Features and Texture Features. (2012)
  • Author(s): Hizukuri A, Nakayama R, Kashikura Y, Kawanaka H, Takase H, Ogawa T, Tsuruoka S.
  • Journal Title: Proc. of the Fourth International Workshop on Regional Innovation Studies - Biomedical Engineering - Volume: 1 Pages: 83-86
  • Peer Reviewed
• [Journal Article] Computerized Segmentation Method for Individual Calcifications within Clustered Microcalcifications while Maintaining Their Shapes on Magnification Mammograms. (2012)
  • Author(s): Hizukuri A, Nakayama R, Nakako N, Kawanaka H, Takase H, Yamamoto K, Tsuruoka S
  • Journal Title: Journal of Digital Imaging Volume: 25(3) Issue: 3 Pages: 377-386
  • DOI: 10.1007/s10278-011-9420-z
  • Peer Reviewed
• [Journal Article] Computer-aided Detection Scheme for Sentinel Lymph Nodes in Lymphoscintigrams Using Symmetrical Property around Mapped Injection Point. (2012)
  • Author(s): Nakayama R, Hizukuri A, Yamamoto K, Nakako N, Nagasawa N, Takeda K.
  • Journal Title: Journal of Digital Imaging Volume: 25(1) Issue: 1 Pages: 148-154
  • DOI: 10.1007/s10278-011-9396-8
  • Peer Reviewed
• [Journal Article] Computerized Quantification Method for Objective Features based on Clinicians' Subjective Ratings of Breast Masses on Ultrasonographic Images. Proc. the Third International Workshop on Regional Innovation Studies - Biomedical Engineering - (2011)
  • Author(s): Hizukuri A, Nakayama R, Kashikura Y, Ogawa T, Tsuruoka S
  • Journal Title: Tsu Pages: 33-36
• [Journal Article] Evaluation of Objective Similarity Measures for Selecting Similar Images of Mammographic Lesions (2011)
  • Author(s): Nakayama R, Abe H, Shiraishi J, Doi K
  • Journal Title: Evaluation of Objective Similarity Measures for Selecting Similar Images of Mammographic Lesions Volume: 24(1) Pages: 75-85
• [Journal Article] Computerized Quantification Method for Objective Features based on Clinicians’ Subjective Ratings of Breast Masses on Ultrasonographic Images (2011)
  • Author(s): Akiyoshi Hizukuri, Ryohei Nakayama, Yumi Kashikura, Tomoko Ogawa, Shinji Tsuruoka
  • Journal Title: Proc. the Third International Workshop on Regional Innovation Studies - Biomedical Engineering - Volume: 1 Pages: 33-36
  • Peer Reviewed
• [Journal Article] Computerized Determination Scheme for Histological Classification of Breast Mass Using Objective Features Corresponding to Clinicians' Subjective Impressions on Ultrasonographic Images
  • Author(s): Hizukuri A, Nakayama R, Kashikura Y, Takase H, Kawanaka H, Ogawa T, Tsuruoka S
  • Journal Title: Journal of Digital Imaging Volume: (in publish)
• [Presentation] Usefulness of Computer-aided Diagnosis Scheme for Determining Histological Classifications of Breast Masses on Ultrasonographic Images (2012)
  • Author(s): Nakayama R, Kashikura Y, Honda E, Hizukuri A, Nakako N, Namba K, Sakuma H
  • Organizer: RSNA2012
  • Place of Presentation: Chicago
• [Presentation] Improved Differential Diagnosis of Breast Masses on Ultrasonographic Images with CAD Scheme for Determining Histological Classifications (2012)
  • Author(s): Kashikura Y, Nakayama R, Hizukuri A, Nohara Y, Yamashita M, Ogawa T
  • Organizer: RSNA2012
  • Place of Presentation: Chicago
• [Presentation] 乳房超音波画像上の腫瘤病変に対する医師の主観的印象に基づいた画像特徴の定量化法 (2012)
  • Author(s): 檜作彰良, 中山良平, 柏倉由実, 小川朋子, 鶴岡信治
  • Organizer: 平成24年度日本生体医工学会東海支部大会
  • Place of Presentation: 名古屋
• [Presentation] Computer-aided Detection Scheme for Clustered Microcalcifications in Telediagnostic System via Telemedicine Network (2012)
  • Author(s): Nakayama R, Nakako N, Hizukuri A, Nagasawa N, Kobayashi S, Takeda K, NambaK
  • Organizer: CARS2012
  • Place of Presentation: Pisa
• [Presentation] Improvement of CAD scheme for histological classification of masses on ultrasonographic images by using objective features based on clinicians' subjective impressions (2012)
  • Author(s): Hizukuri A, Nakayama R, Kashikura Y, Ogawa T, Tsuruoka S
  • Organizer: CARS 2012
  • Place of Presentation: Pisa
• [Presentation] Usefulness of Computer-aided Diagnosis Scheme for Determining Histological Classifications of Breast Masses on Ultrasonographic Images. (2012)
  • Author(s): Nakayama R, Kashikura Y, Honda E, Hizukuri A, Nakako N, Namba K, Sakuma H.
  • Organizer: RSNA2012
  • Place of Presentation: シカゴ
• [Presentation] Improved Differential Diagnosis of Breast Masses on Ultrasonographic Images with CAD Scheme for Determining Histological Classifications. (2012)
  • Author(s): Kashikura Y, Nakayama R, Hizukuri A, Nohara Y, Yamashita M, Ogawa T.
  • Organizer: RSNA2012
  • Place of Presentation: シカゴ
• [Presentation] 平成24年度日本生体医工学会東海支部大会 (2012)
  • Author(s): 檜作彰良, 中山良平, 柏倉由実, 小川朋子, 鶴岡信治.
  • Organizer: 平成24年度日本生体医工学会東海支部大会
  • Place of Presentation: 名古屋
• [Presentation] Computer-aided Detection Scheme for Clustered Microcalcifications in Telediagnostic System via Telemedicine Network (2012)
  • Author(s): Nakayama R, Nakako N, Hizukuri A, Nagasawa N, Kobayashi S, Takeda K, Namba K
  • Organizer: CARS2012
  • Place of Presentation: ピサ
• [Presentation] Improvement of CAD scheme for histological classification of masses on ultrasonographic images by using objective features based on clinicians’ subjective impressions. (2012)
  • Author(s): Hizukuri A, Nakayama R, Kashikura Y, Ogawa T, Tsuruoka S
  • Organizer: CARS 2012
  • Place of Presentation: ピサ
• [Presentation] Construction of Telediagnostic System via Telemedicine Network with Computer-aided Diagnosis (CAD) Scheme for Determining Histological Classification of Clustered Microcalcifications in Mammograms (2011)
  • Author(s): Nakayama R, Namba K, Hizukuri A, NakakoN, Takeda K
  • Organizer: RSNA2011
  • Place of Presentation: Chicago
• [Presentation] Introduction of Computer-aided Detection (CAD) Scheme for Clustered Microcalcifications in Mammograms to Telediagnostic System via Telemedicine Network (2011)
  • Author(s): Nakayama R, Namba K, Nagasawa N, NakakoN, Hizukuri A, Kobayashi S, Sakuma H, Takeda K
  • Organizer: RSNA2011
  • Place of Presentation: Chicago
• [Presentation] Computer-aided Diagnosis Scheme for Determining Histological Classifications of Breast Masses Using Objective Features Based on Clinicians' Subjective Impressions on Ultrasonographic Images (2011)
  • Author(s): Hizukuri A, Nakayama R, Namba K, NakakoN, Sakuma H, Takeda K, Tsuruoka S
  • Organizer: RSNA2011
  • Place of Presentation: Chicago
• [Presentation] 乳房超音波画像における腫瘤像の病理組織型の分類法 (2011)
  • Author(s): 檜作彰良, 中山良平, 柏倉由実, 中子敦雄, 川中普晴, 高瀬治彦, 小川朋子, 鶴岡信治
  • Organizer: 電子情報通信学会技術報告
  • Place of Presentation: 名古屋
• [Presentation] Computer-aided Diagnosis Scheme for Determining Histological Classifications of Breast Masses Using Objective Features Based on Clinicians’ Subjective Impressions on Ultrasonographic Images (2011)
  • Author(s): Akiyoshi Hizukuri, Ryohei Nakayama, Kiyoshi Namba, Nobuo Nakako, Hajime Sakuma, Kan Takeda, Shinji Tsuruoka
  • Organizer: RSNA2011
  • Place of Presentation: シカゴ
• [Presentation] Computer-aided Diagnosis Scheme Based on Histological Classifications of Breast Masses on Ultrasonographic Images (2011)
  • Author(s): Akiyoshi Hizukuri, Ryohei Nakayama, Yumi Kashikura, Nobuo Nakako, Tomoko Ogawa, Shinji Tsuruoka
  • Organizer: CARS2011
  • Place of Presentation: ベルリン
• [Book] 実践医用画像解析ハンドブック (2013)
  • Author(s): 中山良平,他
  • Publisher: オーム社