Non-invasive tumor therapy byusing ultrasound NO generation

Research Project

Project/Area Number	23700581
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Medical systems
Research Institution	Jikei University School of Medicine
Principal Investigator	ENDOH Reiko 東京慈恵会医科大学, 医学部, 助教 (40433982)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords	低侵襲治療システム / 超音波NO産生 / 超音波 / 一酸化窒素 / 腫瘍 / 血管透過性
Research Abstract	Our goal is non-invasive tumor therapy by using ultrasound Nitric Oxide (NO) generation. In this study, we established a measurement model of NO generation with a normal tissue. The ultrasound NO generation with a normal tissue was lower compared with a tumor. Tumor-bearing rats were prepared, and the influence on tumor vessels by the ultrasound NO generation was investigated. As the results, we found that tumor vascular permeability temporarily increased at the same time as the NO generation in the inside of the tumor increased temporarily by the ultrasound irradiation.

Report

(3 results)