Development of a thermal treatment system combined with drug-delivery imaging using a multi-functional thermo-sensitive nano-carrier

Research Project

Project/Area Number	23700589
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Medical systems
Research Institution	National Institute of Radiological Sciences
Principal Investigator	KOKURYO Daisuke 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (20508543)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	低侵襲治療 / 薬剤送達 / 磁気共鳴画像 / 温熱療法 / 薬剤送達システム / 加温治療
Research Abstract	The purpose of this study was to develop a thermal treatment system combined with drug-delivery imaging using a multi-functional thermo-sensitive liposome. The dynamics of the liposomes in tumor and normal tissues such as liver and kidney was evaluated using quantitative MR imaging techniques. Also, a real-time visualization system for temperature changes and treatment effects was developed and an investigation of heating in the MR scanner with an ultrasound probe was performed.