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Development of a thermal treatment system combined with drug-delivery imaging using a multi-functional thermo-sensitive nano-carrier

Research Project

Project/Area Number 23700589
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical systems
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

KOKURYO Daisuke  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (20508543)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords低侵襲治療 / 薬剤送達 / 磁気共鳴画像 / 温熱療法 / 薬剤送達システム / 加温治療
Research Abstract

The purpose of this study was to develop a thermal treatment system combined with drug-delivery imaging using a multi-functional thermo-sensitive liposome. The dynamics of the liposomes in tumor and normal tissues such as liver and kidney was evaluated using quantitative MR imaging techniques. Also, a real-time visualization system for temperature changes and treatment effects was developed and an investigation of heating in the MR scanner with an ultrasound probe was performed.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (1 results)

All 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Evaluation of a vessel-tracking-based technique for dynamic targeting in human liver2012

    • Author(s)
      Daisuke Kokuryo, Etsuko Kumamoto, Yoshie Takao, Susumu Fuji, Toshiya Kaihara, Kagayaki Kuroda
    • Journal Title

      Magnetic Resonance in Medicine

      Volume: Vol.67, No.1 Issue: 1 Pages: 156-163

    • DOI

      10.1002/mrm.23005

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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