Investigation of mechanism for spasticity after cortical injury
| Project/Area Number |
23700598
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
LEE Sachiko 名古屋大学, 医学系研究科(保健), 助教 (80599316)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 理学療法学 / 痙縮 / 脳卒中 / Spasticity / Cortical injury / Hoffman reflex / KCC2 / serotonin |
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| Research Abstract |
We made photothrombotic injury in rostral and caudal forelimb motor areas in mice. We employedthe rate dependent depression (RDD) of the Hoffman reflex as a reliable measurement of spasticity and we examined expression of the mRNA for c-fos and c-Fos immunoreactivity for motoneuron excitability. The RDD in the affected muscles of infarcted animals were significantly weakened 3 days after stroke until 8 weeks after the stroke, except at 3 weeks after the stroke, compared to sham-operated mice. The c-fos expression was significantly increased in stroke animals. These results revealed that lesions of the rostral-caudal forelimb areas induced spasticity as evidenced, which was due to the weakened RDDs of the Hoffman reflexes and increased motoneuron excitability.
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Report
(3 results)
Research Products
(12 results)
