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Identification of main factor of pressure ulcer formation, and prevention by phsical agents

Research Project

Project/Area Number 23700602
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionHiroshima University

Principal Investigator

KUROSE Tomoyuki  広島大学, 医歯薬保健学研究院, 助教 (20363054)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords褥瘡 / 血流 / トマトレクチン / 炎症性サイトカイン / Real-Time PCR / Western Blot / 磁石 / 圧迫 / ウェスタンブロット / 血管開通率 / ラット / 皮膚温 / 酸化ストレス
Research Abstract

We produced the experimental pressure ulcer model rat to clear the mechanism of pressure ulcers. Repeated compression at 50mmHg for 4 hours did not cause the macroscopic and microscopic alteration. But, repeated compression at 100mmHg for 4 hours induces the destruction of skin and ulcer formation. Expression of IL-1beta, which is an inflammatory cytokine, was not changed at 50mmHg compression. Compression at 100mmHg cause high expression of IL-1beta, and increased with compression times. TNF-alpha was not changed at 50mmHg compression ,and slightly increased at 100mmHg compression.
Inhibition of inflammatory cytokine may have possibility to prevent the pressure ulcers.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (30 results)

All 2014 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (25 results)

  • [Journal Article] Effects of the magnitude of pressure on the severity of injury and capillary closure in rat experimental pressure ulcers2014

    • Author(s)
      Kawamata S, Kurose T 他3名
    • Journal Title

      Med Mol Morphol.

      Volume: (印刷中)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between gastrocnemius muscle weakness and moderate exercise deteriorates joint integrity in rat knee2014

    • Author(s)
      Ozawa J, Kaneguchi A 他7名
    • Journal Title

      Scand J Med Sci Sports

      Volume: (印刷中) Issue: 1

    • DOI

      10.1111/sms.12195

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the magnitude of pressure on the severity of injury and capillary closure in rat experimental pressure ulcers.2014

    • Author(s)
      Kawamata S, Kurose T, Kubori Y, Muramoto H, Honkawa Y
    • Journal Title

      Med Mol Morphol

      Volume: 印刷中 Issue: 1 Pages: 24-32

    • DOI

      10.1007/s00795-014-0073-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of connective tissue remodeling in the early phase of denervation in a rat skeletalmuscle2013

    • Author(s)
      Ozawa J, Kurose T 他4名
    • Journal Title

      Biomed Res

      Volume: 34 Pages: 251-258

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development and repair of experimental pressure ulcers in the rat abdominal wall induced by repeated compression using magnets2013

    • Author(s)
      Kawamata S, Kurose T, Honkawa Y, Kubori Y, Muramoto H
    • Journal Title

      Arch Histol Cytol

      Volume: 印刷中

    • NAID

      130005087020

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ラット下腿の温度変化に対する骨格筋毛細血管の血流変化2014

    • Author(s)
      前田久、黒瀬智之、川真田聖一
    • Organizer
      第118回日本解剖学会全国学術集会
    • Place of Presentation
      栃木県下野市
    • Year and Date
      2014-03-27
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット下腿の温度変化に対する骨格筋毛細血管の血流変化2014

    • Author(s)
      前田久、黒瀬智之、野坂進之介、川真田聖一
    • Organizer
      第119回日本解剖学会総会全国学術集会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット正常器官の毛細血管開通率2013

    • Author(s)
      前田久、黒瀬智之、川真田聖一
    • Organizer
      第12回コ・メディカル形態機能学会学術集会
    • Place of Presentation
      広島県呉市
    • Year and Date
      2013-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 温度変化が骨格筋毛細血管開通率に与える影響2013

    • Author(s)
      前田久、黒瀬智之、川真田聖一
    • Organizer
      第12回コ・メディカル形態機能学会学術集会
    • Place of Presentation
      広島県呉市
    • Year and Date
      2013-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット褥瘡実験モデルにおける圧力と傷害の重症度および虚血程度の検討2012

    • Author(s)
      川真田聖一、黒瀬智之
    • Organizer
      第11回コ・メディカル形態機能学会学術集会
    • Place of Presentation
      東京都荒川区
    • Year and Date
      2012-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] The effect of tissue temperature on capillary opening and closing in the rat abdominal wall2012

    • Author(s)
      Kurose T, Nosaka S, Kawamata S
    • Organizer
      14th International Congress of Histochemistry and Cytochemistry
    • Place of Presentation
      京都.日本
    • Year and Date
      2012-08-29
    • Related Report
      2013 Final Research Report
  • [Presentation] The effect ofpressure on capillary closure in therat abdominalwall2012

    • Author(s)
      Kawamata S, Kurose T
    • Organizer
      14th International Congress ofHistochemistry and Cytochemistry
    • Place of Presentation
      京都.日本
    • Year and Date
      2012-08-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Experimental pressure ulcers in the rat abdominal wall induced by repeated compression using magnets2012

    • Author(s)
      Kurose T, Maeda S, Kawamata S
    • Organizer
      the 4th Congress of the World Union of Wound Healing Societies
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] The effect of pressure on capillary closure in the rat abdominal wall2012

    • Author(s)
      Kawamata S, Kurose T
    • Organizer
      14th International Congress of Histochemistry and Cytochemistry
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Research-status Report
  • [Presentation] The effect of tissue temperature on capillary opening and closing in the rat abdominal wall2012

    • Author(s)
      Kurose T, Nosaka S, Maeda H, Kawamata S
    • Organizer
      14th International Congress of Histochemistry and Cytochemistry
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Research-status Report
  • [Presentation] Development and repair process of experimental pressure ulcers induced by repeated compressions using magnets in the rat2012

    • Author(s)
      Kurose T, Kawamata S
    • Organizer
      4th Congress of the World Union of Wound Healing Societies
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Research-status Report
  • [Presentation] ラット褥瘡実験モデルにおける圧力と傷害の重症度および虚血程度の検討2012

    • Author(s)
      川真田聖一、黒瀬智之
    • Organizer
      第11回コ・メディカル形態機能学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] ラット褥瘡モデルによる繰り返し圧迫傷害の発生と治癒過程2011

    • Author(s)
      川真田聖一,黒瀬智之
    • Organizer
      第10回コ・メディカル形態機能学会学術集会
    • Place of Presentation
      愛知県春井市
    • Year and Date
      2011-09-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 磁石を使用した繰り返し圧迫によるラット褥瘡モデルの開発2011

    • Author(s)
      川真田聖一,黒瀬智之
    • Organizer
      第13回日本褥瘡学会学術集会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2011-08-26
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] ラット褥瘡モデルを用いた圧力と傷害の関係2011

    • Author(s)
      黒瀬智之,川真田聖一
    • Organizer
      第13回日本褥瘡学会学術集会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2011-08-26
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] A novel animal model for studying pressure ulcers induced by repeated compression of the rat abdominal wall using magnets2011

    • Author(s)
      Kawamata, S., Kurose, T.
    • Organizer
      6th Asian-Pacific InternationalCongress of Anatomists
    • Place of Presentation
      インドネシア、スラバヤ
    • Year and Date
      2011-07-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Geneexpression profiles of pressure ulcers; focus on inflammatory cytokines2011

    • Author(s)
      Kurose, T., Kawamata, S
    • Organizer
      6th Asian-Pacific International Congress of Anatomists
    • Place of Presentation
      インドネシア、スラバヤ
    • Year and Date
      2011-07-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Fibrotic process of rat skeletal muscle following an experimentally induced denervation2011

    • Author(s)
      Ozawa J, Kaneguchi A, Kurose T, Kawamata S, Moriyama H, Kito N, Yamaoka K
    • Organizer
      the 16th WCPT congress
    • Place of Presentation
      オランダ、アムステルダム
    • Year and Date
      2011-06-23
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Preventive effects of intermittent whole-body vibration on muscle atrophy and capillary density reduction in unloaded rat skeletal muscle2011

    • Author(s)
      Kaneguchi A, Ozawa J, Kurose T, Kawamata S, Moriyama H, Kito N, Saka Y, Yamaoka K
    • Organizer
      the 16th WCPT congress
    • Place of Presentation
      オランダ、アムステルダム
    • Year and Date
      2011-06-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene expression profiles of pressure ulcers; focus on inflammatory cytokines.2011

    • Author(s)
      Kurose, T., Kawamata, S
    • Organizer
      6th Asian- Pacific International Congress of Anatomists
    • Place of Presentation
      インドネシア、スラバヤ
    • Related Report
      2011 Research-status Report
  • [Presentation] A novel animal model for studying pressure ulcers induced by repeated compression of the rat abdominal wall using magnets.2011

    • Author(s)
      Kawamata, S., Kurose, T.
    • Organizer
      6th Asian- Pacific International Congress of Anatomists
    • Place of Presentation
      インドネシア、スラバヤ
    • Related Report
      2011 Research-status Report
  • [Presentation] Preventive effects of intermittent whole-body vibration on muscle atrophy and capillary density reduction in unloaded rat skeletal muscle.2011

    • Author(s)
      Kaneguchi A, Ozawa J, Kurose T, Kawamata S, Moriyama H, Kito N, Saka Y, Yamaoka K.
    • Organizer
      the 16th WCPT congress
    • Place of Presentation
      オランダ、アムステルダム
    • Related Report
      2011 Research-status Report
  • [Presentation] ラット褥瘡モデルによる繰り返し圧迫傷害の発生と治癒過程2011

    • Author(s)
      川真田聖一,黒瀬智之
    • Organizer
      第10回コ・メディカル形態機能学会学術集会
    • Place of Presentation
      愛知県春日井市
    • Related Report
      2011 Research-status Report
  • [Presentation] ラット正常器官の毛細血管開通率

    • Author(s)
      前田 久、黒瀬智之、川真田聖一
    • Organizer
      コ・メディカル形態機能学会 第 12 回学術集会・総会
    • Place of Presentation
      広島国際大学 呉キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 温度変化が骨格筋毛細血管開通率に与える影響

    • Author(s)
      前田 久、黒瀬智之、川真田聖一
    • Organizer
      コ・メディカル形態機能学会 第 12 回学術集会・総会
    • Place of Presentation
      広島国際大学 呉キャンパス
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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