| Project/Area Number |
23700605
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKITA Minoru 長崎大学, 医歯薬学総合研究科, 教授 (50244091)
NAKANO Jiro 長崎大学, 医歯薬学総合研究科, 准教授 (20380834)
SAKAMOTO Junya 長崎大学, 医歯薬学総合研究科, 准教授 (20584080)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ステロイド筋症 / 温熱刺激 / 低強度筋収縮運動 / Hsp72 / UPS / 筋萎縮 / 低強度運動 / ステロイド |
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| Research Abstract |
A number of patients with various medical conditions undergo steroid therapy to prevent inflammation or immunization in several medical conditions. However, it is well known that steroids progressively impact health during continued use owing to their side effects. Amongst these, steroid myopathy, characterized by muscle fiber atrophy, is one such condition that drastically affects a patient's life. In this study, we elucidate that low-intensity exercise and heat stress can prevent steroid myopathy and establish that a combination of both is more effective than an individual treatment in preventing the progress of steroid myopathy. It is possible that the mechanism by which heat stress prevents steroid myopathy involves an increase in heat shock protein 72 and an inhibition of muscle protein breakdown.
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