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Functional and morphological analysis of neural circuits for taste aimed at clinical application of gustatory BMI.

Research Project

Project/Area Number 23700610
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKanazawa Medical University (2013)
Kagoshima University (2011-2012)

Principal Investigator

SONOMURA Takahiro  金沢医科大学, 医学部, 講師 (40347092)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords味覚 / BMI / 脳 / 神経科学 / QOL / 人工感覚器 / Juxtacellular Recording法 / 脳科学 / ラット / ブレイン・マシン-インターフェース / 三次元再構築 / 中枢神経 / juxtacellular / コモンマーモセット
Research Abstract

The progress in brain–machine interface in recent years is remarkable. For example, the artificial arms which move freely as thought in the brain, and the artificial cochleas which recover deafness persons have been developed. However, the trial of the gustatory BMI to those who have lost the taste is not yet performed. Although the main functions of oral cavity are ingestion of nutrition, it is very important for improvement in QOL that people taste foods through the mouth deliciously and safely until the last day of the life. So, in the present research, we tried to provide the fundamental informations for development of the gustatory BMI using the newly developed Juxtacellular Recording method.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (35 results)

All 2014 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (24 results) (of which Invited: 3 results) Remarks (1 results)

  • [Journal Article] Localization of masticatory motoneurons in the trigeminal motor nucleus of shrew and pig, with emphasis on the innervation ratio in the shrew2013

    • Author(s)
      Uemura M, Sonomura T, Iwai H, Yamanaka A
    • Journal Title

      Journal of Oral Biosciences

      Volume: 55(2): Pages: 101-107

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 顎顔面の運動神経細胞の脳内分布、および味覚神経回路2013

    • Author(s)
      植村正憲、薗村貴弘、岩井治樹、山中淳之
    • Journal Title

      鹿児島大学歯学部紀要

      Volume: 33 Pages: 3-17

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlative Analysis of Immunoreactivity in Confocal Laser-Scanning Microscopy and Scanning Electron Microscopy with Focused Ion Beam Milling2013

    • Author(s)
      Sonomura T, Furuta T, Nakatani I, Yamamoto Y, Unzai T, Matsuda W, Iwai H, Yamanaka A, Uemura M, Kaneko T
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 7(26) Pages: 1-7

    • NAID

      120005303690

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlative analysis of immunoreactivity in confocal laser-scanning microscopy and scanning electron microscopy with focused ion beam milling2013

    • Author(s)
      Sonomura T, Furuta F, Nakatani I, Yamamoto Y, Unzai T, Matsuda W, Iwai H, Yamanaka A, Uemura M, Kaneko T
    • Journal Title

      Frontiers in Neural Circuits

      Volume: vol. 7 Pages: 1-7

    • DOI

      10.3389/fncir.2013.00026

    • NAID

      120005303690

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Parvalbumin-producing cortical interneurons receive inhibitory inputs on proximal portions and cortical excitatory inputs on distal dendrites2012

    • Author(s)
      Kameda H, Hioki H, Tanaka YH, Tanaka T, Zaerin S, Sonomura T, Furuta T, Fujiyama F, Kaneko T
    • Journal Title

      European Journal of Neuroscience

      Volume: 35(6) Pages: 838-854

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphological analysis of thalamocortical axon fibers of rat posterior thalamic nuclei : A single neuron tracing study with viral vectors2012

    • Author(s)
      Ohno S, Kuramoto E, Furuta T, Hioki H, Tanaka YR, Fujiyama F, Sonomura T, Uemura M, Sugiyama K and Kaneko T
    • Journal Title

      Cerebral Cortex

      Volume: 22(12) Pages: 2840-2857

    • NAID

      120005243652

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphological analysis of thalamocortical axon fibers of rat posterior thalamic nuclei: A single neuron tracing study with viral vectors2012

    • Author(s)
      Ohno S, Kuramoto E, Furuta T, Hioki,H Tanaka YR, Fujiyama F, Sonomura T,Uemura M, Sugiyama K, Kaneko T
    • Journal Title

      Cerebral Cortex

      Volume: vol. 22 Issue: 12 Pages: 2840-2857

    • DOI

      10.1093/cercor/bhr356

    • NAID

      120005243652

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Parvalbuminproducing cortical Interneurons receive inhibitory inputs on Proximal portions and cortical excitatory inputs on distal dendrites.2012

    • Author(s)
      Kameda H, Hioki H, Tanaka YH, Tanaka T, Sohn J, Sonomura T, Furuta T,Fujiyama F, Kaneko T
    • Journal Title

      European Journal of Neuroscience

      Volume: vol. 35 (no. 6) Issue: 6 Pages: 834-854

    • DOI

      10.1111/j.1460-9568.2012.08027.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Local connections of excitatory neurons to corticothalamic neurons in the rat barrel cortex2011

    • Author(s)
      Tanaka YR, Tanaka YH, Konno M, Fujiyama F, Sonomura T, Okamoto-Furuta K, Kameda H, Hioki H, Furuta T, Nakamura KC and Kaneko T
    • Journal Title

      Journal of Neuroscience

      Volume: 31(50) Pages: 18223-18236

    • NAID

      120004397861

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Local connections of excitatory neurons to corticothalamic neurons in the rat barrel cortex.2011

    • Author(s)
      Tanaka YR, Tanaka YH, Konno M,Fujiyama F, Sonomura T, Okamoto-FurutaK, Kameda H, Hioki H, Furuta T,Nakamura KC, Kaneko T
    • Journal Title

      Journal of Neuroscience

      Volume: vol. 31 (no. 50) Issue: 50 Pages: 18223-28236

    • DOI

      10.1523/jneurosci.3139-11.2011

    • NAID

      120004397861

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 共焦点レーザー顕微鏡と FIB-SEMによる二重免疫染色標本のCorrelative三次元再構築法2014

    • Author(s)
      薗村貴弘 ,古田貴寛 ,中谷郁子 ,山本洋 ,金子武嗣
    • Place of Presentation
      栃木県下野市
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Correlative three-dimensional reconstruction for confocal laser-scanning microscope and FIB/SEM in the Double immunohistochemical staining2014

    • Author(s)
      Sonomura T, Furuta T, Nakatani I, Yamamoto Y, Kaneko T
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2014-03-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Correlative three-dimensional reconstruction for confocal laser-scanning microscope and FIB/SEM in the Double immunohistochemical staining2014

    • Author(s)
      Sonomura T, Furuta T, Nakatani I, Yamamoto Y, Kaneko T
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島市(鹿児島大学)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 共焦点レーザー顕微鏡とFIB-SEMによる二重免疫染色標本のCorrelative三次元再構築法2014

    • Author(s)
      薗村貴弘,古田貴寛,中谷郁子,山本洋,金子武嗣
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      栃木県下野市(自治医科大学)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 多重免疫組織染色標本における共焦点レーザー顕微鏡とFIB/SEMを一致させた三次元再構築法2013

    • Author(s)
      薗村貴弘 ,古田貴寛 ,中谷郁子 ,山本洋 ,金子武嗣
    • Organizer
      第54回日本組織細胞化学会総会
    • Place of Presentation
      東京都港区
    • Year and Date
      2013-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 中脳非ドパミン神経細胞の投射様式を解析する2013

    • Author(s)
      松田和郎、古田貴寛、薗村貴弘、金子武嗣、宇田川潤
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川
    • Year and Date
      2013-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] The alternation of emotional behavior induced by combination of repeated stress and ovariectomy mediated by GABAergic neuronal dysfunction in mice2013

    • Author(s)
      Tsukahara T, Masuhara M, Sonomura T, Uemura M, Sato T
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 多重免疫組織染色標本における共焦点レーザー顕微鏡とFIB/SEMを一致させた三次元再構築法2013

    • Author(s)
      薗村貴弘,古田貴寛,中谷郁子,山本洋,金子武嗣
    • Organizer
      第54回日本組織細胞化学会総会
    • Place of Presentation
      東京都港区(航空会館)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The alternation of emotional behavior induced by combination of repeated stress and ovariectomy mediated by GABAergic neuronal dysfunction in mice.2013

    • Author(s)
      Takao Tsukahara, Masaaki Masuhara, Takahiro Sonomura, Masahori Uemura, Tomoaki Sato
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 中脳非ドパミン神経細胞の投射様式を解析する2012

    • Author(s)
      松田和郎、古田貴寛、薗村貴弘、金子武嗣、宇田川潤
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      愛知
    • Year and Date
      2012-09-19
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] ストレスが閉経マウスモデルの情動およびGABA機能に与える影響2012

    • Author(s)
      塚原飛央、増原正明、薗村貴弘、永山知宏、植村正憲、佐藤友昭
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福島
    • Year and Date
      2012-09-15
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] A Morphological Analysis of Thalamocortical Axon Fibers of Rat Posterior Thalamic Nuclei : A Single Neuron Tracing Study with Viral Vectors2012

    • Author(s)
      Ohno S, Kuramoto E, Furuta T, Hioki H, Tanaka YR, Fujiyama F, Sonomura T, Uemura M, Sugiyama K , Kaneko T
    • Organizer
      8th THE FEDERATION OF EUROPEAN NEUROSCIENCE SOCIETIES FORUM OF NEUROSCIENCE
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2012-07-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 集束イオンビーム/走査電子顕微鏡と共焦点レーザー顕微鏡を組み合わせたシナプスの統計的解析の試み2012

    • Author(s)
      薗村貴弘、古田貴寛、雲財知、松田和郎、岩井治樹、山中淳之、藤山文乃、植村正憲、金子武嗣
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Year and Date
      2012-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] A Morphological Analysis of Thalamocortical Axon Fibers of Rat Posterior Nuclei : A Single Neuron Tracing Study with Viral Vectors2012

    • Author(s)
      大野幸、倉本恵梨子、古田貴寛、日置寛之、田中康裕、藤山文乃、薗村貴弘、植村正憲、椙山加綱、金子武嗣
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Year and Date
      2012-03-27
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットにおける結合腕傍核・視床ニューロンと視床・線条体ニューロンの神経連絡2012

    • Author(s)
      岩井治樹、薗村貴弘、山中淳之、植村正憲
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Year and Date
      2012-03-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 皮質視床投射神経細胞への局所回路内興奮性入力2012

    • Author(s)
      田中康裕、田中康代、今野美知輝、藤山文乃、薗村貴弘、岡本‐古田敬子、亀田浩司、日置寛之、古田貴寛、中村公一、金子武嗣
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Year and Date
      2012-03-26
    • Related Report
      2013 Final Research Report
  • [Presentation] A Morphological Analysis of Thalamocortical Axon Fibers of Rat Posterior Thalamic Nuclei: A Single Neuron Tracing Study with Viral Vectors2012

    • Author(s)
      Ohno S, Kuramoto E, Furuta T, Hioki H, Tanaka YR, Fujiyama F, Sonomura T, Uemura M, Sugiyama K & Kaneko T
    • Organizer
      8th THE FEDERATION OF EUROPEAN NEUROSCIENCE SOCIETIES FORUM OF NEUROSCIENCE
    • Place of Presentation
      Spain
    • Related Report
      2012 Research-status Report
  • [Presentation] 皮質視床投射神経細胞への局所回路内興奮性入力2012

    • Author(s)
      田中 康裕、田中 康代、今野 美知輝、藤山 文乃、薗村 貴弘、岡本‐古田 敬子、亀田 浩司、日置 寛之、古田 貴寛、中村 公一、金子 武嗣
    • Organizer
      第 117 回日本解剖学会総会・全国学術集会(招待講演)
    • Place of Presentation
      山梨
    • Related Report
      2011 Research-status Report
  • [Presentation] 集束イオンビーム/走査電子顕微鏡と共焦点レーザー顕微鏡を組み合わせたシナプスの統計的解析の試み2012

    • Author(s)
      薗村貴弘、古田貴寛、雲財知、松田和郎、岩井治樹、山中淳之、藤山文乃、植村正憲、金子武嗣
    • Organizer
      第 117 回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Related Report
      2011 Research-status Report
  • [Presentation] A Morphological Analysis of Thalamocortical Axon Fibers of Rat Posterior Nuclei: A Single Neuron Tracing Study with Viral Vectors2012

    • Author(s)
      大野 幸、倉本 恵梨子、古田 貴實、日置 寛之、田中 康裕 、藤山 文乃、薗村 貴弘、植村 正憲、椙山 加綱、金子 武嗣
    • Organizer
      第 117 回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Related Report
      2011 Research-status Report
  • [Presentation] ラットにおける結合腕傍核・視床ニューロンと視床・線条体ニューロンの神経連絡2012

    • Author(s)
      岩井 治樹、薗村 貴弘、山中 淳之、植村 正憲
    • Organizer
      第 117 回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Related Report
      2011 Research-status Report
  • [Presentation] Attempt of quantitative analysis of morphological synaptic connectivity by combining focused ion beam milling and scanning electron microscopy (FIB-SEM) and confocal laser-scanning microscope2011

    • Author(s)
      Sonomura T, Furuta T, Unzai T, Matsuda W, Iwai H, Fujiyama F, Uemura M, Kaneko T
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-09-16
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Axonal arborization of midbrain non-dopaminergic neurons : single-cell study2011

    • Author(s)
      Matsuda W, Furuta T, Sonomura T, KanekoT, Yasuhara O, Kudo M
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Axonal arborization of midbrain non-dopaminergic neurons: single-cell study2011

    • Author(s)
      Wakoto Matsuda, Takahiro Furuta, Takahiro Sonomura, Takeshi Kaneko, Osamu Yasuhara, Motoi Kudo
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      神奈川
    • Related Report
      2011 Research-status Report
  • [Remarks] (掲載準備中)

    • URL

      http://www.kanazawa-med.ac.jp/~anatomy2/sonomura/sonomura.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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