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Development of assessments for behavioral symptom linked to a dysfunctional ventromedial prefrontal cortex (VMPFC): Characterization of emotion on false memory production related to VMPFC

Research Project

Project/Area Number 23700617
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionSaitama Prefectural University

Principal Investigator

Ishioka Toshiyuki  埼玉県立大学, 保健医療福祉学部, 講師 (50548914)

Project Period (FY) 2011-04-28 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords腹内側前頭前野 / 情動記憶 / 過誤記憶 / リハビリテーション / 作業療法 / 虚再認 / 腹内側前頭前皮質 / 内側前頭前野 / 情動 / 記憶 / モラル判断 / 行動神経科学
Outline of Final Research Achievements

The present study aimed to investigate the effects of emotion on false memories involving roles of ventromedial prefrontal cortex (VMPFC) by evaluating two tasks of false recognition produced by emotion, one task of the Deese-Roediger-McDermott (DRM) paradigm and another task of the directed forgetting paradigm. Results of data on the DRM paradigm task showed that the number of false recognition in negative emotional stimuli is marginally increased than in neutral emotional stimuli. Results of data on the directed forgetting paradigm task revealed that the number of false recognition in negative emotional stimuli is a significant increase in comparison with neutral emotional stimuli, due to the decrease of attentional inhibition playing a role of dorsolateral prefrontal cortex in aging. These results represent an important step toward developing the evidence-based intervention strategy to improve behavioral symptom following damage to the VMPFC.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (5 results) (of which Invited: 1 results)

  • [Journal Article] 脳卒中後うつ症状患者の活動量を高める行動介入の効果2015

    • Author(s)
      滝澤宏和,石岡俊之,田山淳,富家直明,中村裕美,濱口豊太
    • Journal Title

      日本作業療法研究学会雑誌

      Volume: 18 Pages: 35-41

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 記銘時の色光による情動の変化が再認に与える影響2015

    • Author(s)
      槻由夏,石岡俊之
    • Journal Title

      埼玉作業療法研究

      Volume: 15 Pages: 18-24

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 1.Neural Substrates of Cognitive Subtypes in Parkinson's Disease: A 3-Year Longitudinal Study2014

    • Author(s)
      Shoji Y¸ Nishio Y, Baba T, Uchiyama M, Yokoi K, Ishioka T, Hosokai Y, Hirayama K, Fukuda H, Aoki M, Hasegawa T, Takeda A, Mori E.
    • Journal Title

      PLoS ONE

      Volume: 9(10) Issue: 10 Pages: e110547-e110547

    • DOI

      10.1371/journal.pone.0110547

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypometabolism in the supplementary and anterior cingulate cortices is related to dysphagia in Parkinson's disease: a cross-sectional and 3-year longitudinal cohort study.2013

    • Author(s)
      Kikuchi A, Baba T, Hasegawa T, Kobayashi M, Sugeno N, Konno M, Miura E, Hosokai Y, Ishioka T, Nishio Y, Hirayama K, Suzuki K, Aoki M, Takahashi S, Fukuda H, Itoyama Y, Mori E, Takeda A.
    • Journal Title

      BMJ Open

      Volume: 3(3)

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Attentional set-shifting deficit in Parkinson's disease is associated with prefrontal dysfunction: an FDG-PET study2012

    • Author(s)
      Sawada Y, Nishio Y, Suzuki K, Hirayama K, Takeda A, Hosokai Y, Ishioka T, Itoyama Y, Takahashi S, Fukuda H, Mori E
    • Journal Title

      PLoS ONE

      Volume: 7(6)

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Illusory misidentifications and cortical hypometabolism in Parkinson's disease2011

    • Author(s)
      Ishioka T, Hirayama K, Hosokai Y, Takeda A, Suzuki K, et al
    • Journal Title

      Movement disorder

      Volume: 26 Issue: 5 Pages: 837-843

    • DOI

      10.1002/mds.23576

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neural substrates for writing impairments in Japanese patients with mild Alzheimer's disease : A SPECT study2011

    • Author(s)
      Hayashi A, Nomura H, Mochizuki R Ohmuma A, Kinpara T, Ohtomo K, Hosokai Y, Ishioka T, Suzuki K, Mori E
    • Journal Title

      Neuropsychologia

      Volume: 49 Issue: 7 Pages: 1962-1968

    • DOI

      10.1016/j.neuropsychologia.2011.03.024

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 加齢によるネガティブ刺激への意図的な抑制と虚記憶との関係2016

    • Author(s)
      石岡俊之
    • Organizer
      第50回日本作業療法学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腹内側前皮質(VMPFC)損傷による“現在”、“過去”、“未来”の結びつけの失敗2015

    • Author(s)
      石岡俊之
    • Organizer
      札幌高次脳機能障害研究会主催平成27年度特別講演会
    • Place of Presentation
      札幌
    • Year and Date
      2015-08-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病における認知障害サブタイプの神経基盤: PETによる3年間縦断研究2014

    • Author(s)
      庄司裕美子, 西尾慶之, 馬場徹, 内山信, 横井香代子, 石岡俊之, 細貝良行, 平山和美, 福田寛, 青木正志, 長谷川隆文, 武田篤, 森悦朗
    • Organizer
      第16回日本ヒト脳機能マッピング学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] 脳卒中による環指の機能障害と箸動作再獲得との関係:上肢機能検査が高得点でも麻痺側手で箸が使えなかった症例からの検討.2012

    • Author(s)
      石岡俊之,土谷里織,糸瀬佳奈
    • Organizer
      第46回日本作業療法学会
    • Place of Presentation
      宮崎
    • Related Report
      2012 Research-status Report
  • [Presentation] 2. パーキンソン病に対する脳深部刺激術後の前頭葉機能の変化に伴う作業療法の介入検討.2012

    • Author(s)
      佐藤淳矢,久保田富夫,石岡俊之,佐々木一成,済陽輝久
    • Organizer
      第46回日本作業療法学会
    • Place of Presentation
      宮崎
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2023-03-16  

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